INT97600

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Context Info
Confidence 0.52
First Reported 2001
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.14
Pain Relevance 6.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
ovary 2
SK-N-SH 2
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 37 100.00 Very High Very High Very High
mu opioid receptor 20 100.00 Very High Very High Very High
addiction 5 99.76 Very High Very High Very High
withdrawal 10 99.60 Very High Very High Very High
Opioid 22 99.20 Very High Very High Very High
Pain 5 99.00 Very High Very High Very High
Analgesic 5 98.92 Very High Very High Very High
agonist 3 98.64 Very High Very High Very High
Morphine 4 98.44 Very High Very High Very High
adenocard 1 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Dependence 4 99.76 Very High Very High Very High
Pain 5 99.00 Very High Very High Very High
Nociception 2 95.48 Very High Very High Very High
Targeted Disruption 1 91.20 High High
Cancer Pain 1 74.32 Quite High
Neuroblastoma 2 63.28 Quite High
Recurrence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study the 5' regulatory region of the human MOR gene (hMOR), we further investigated our previous finding of two regulatory regions and have localized a 40-bp positive cis-acting element and a 35-bp negative cis-acting element that regulate hMOR transcription in SK-N-SH cells.
Regulation (regulate) of Transcription (transcription) of hMOR in SK-N-SH associated with mu opioid receptor
1) Confidence 0.52 Published 2001 Journal DNA Cell Biol. Section Abstract Doc Link 11506703 Disease Relevance 0.25 Pain Relevance 0.54
The MOR gene is tightly regulated at the level of transcription, and potential polymorphisms in its 5' regulatory region can cause individual variation in MOR gene expression, nociception, and opiate responses.
Regulation (regulated) of Transcription (transcription) of MOR gene associated with nociception, mu opioid receptor and opiate
2) Confidence 0.52 Published 2001 Journal DNA Cell Biol. Section Abstract Doc Link 11506703 Disease Relevance 0.29 Pain Relevance 0.61
The MOR gene is highly regulated at the level of transcription.
Regulation (regulated) of Transcription (transcription) of MOR gene associated with mu opioid receptor
3) Confidence 0.35 Published 2001 Journal Gene Section Abstract Doc Link 11675004 Disease Relevance 0 Pain Relevance 0.58
In conclusion, transcriptional regulation of MOR1 is modified by two genetic variations at positions -554 and -1320 of the mu-opioid receptor promoter.
Regulation (modified) of Transcription (transcriptional) of MOR1 associated with opioid receptor
4) Confidence 0.26 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16843022 Disease Relevance 0.06 Pain Relevance 0.58
In conclusion, transcriptional regulation of MOR1 is modified by two genetic variations at positions -554 and -1320 of the mu-opioid receptor promoter.
Regulation (regulation) of Transcription (transcriptional) of MOR1 associated with opioid receptor
5) Confidence 0.26 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16843022 Disease Relevance 0.06 Pain Relevance 0.58
There is also increasing evidence that differences in the sequence of the MOP gene might significantly affect the amount of MOP gene mRNA expression and sensitivity to opioids.
Spec (might) Regulation (affect) of Transcription (expression) of MOP gene associated with opioid receptor and opioid
6) Confidence 0.25 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 18411709 Disease Relevance 0.32 Pain Relevance 1.63
Transfection into Chinese hamster ovary cells of a cDNA representing only the coding region of OPRM1, carrying adenosine, guanosine, cytidine, and thymidine in position 118, resulted in 1.5-fold lower mRNA levels only for OPRM1-G118, and more than 10-fold lower OPRM1 protein levels, measured by Western blotting and receptor binding assay.
Regulation (measured) of Transcription (levels) of OPRM1-G118 in ovary associated with adenocard
7) Confidence 0.24 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16046395 Disease Relevance 0.15 Pain Relevance 0.37
DOR and MOR mRNA levels were not modified in the NAcSh of rats expressing behavioral sensitization after 2 or 14 days of withdrawal.
Neg (not) Regulation (modified) of Transcription (levels) of MOR associated with opioid receptor and withdrawal
8) Confidence 0.01 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12629526 Disease Relevance 0 Pain Relevance 1.32

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