INT97621

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Context Info
Confidence 0.24
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.08
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lymphocytes 1
T cells 1
Cd8a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 8 99.84 Very High Very High Very High
Serotonin 5 93.48 High High
cytokine 59 93.04 High High
Inflammation 5 91.68 High High
Chronic pancreatitis 3 75.00 Quite High
sSRI 1 66.16 Quite High
antidepressant 3 64.44 Quite High
anesthesia 9 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 78 99.90 Very High Very High Very High
Malignant Neoplastic Disease 18 99.12 Very High Very High Very High
Cancer 147 99.04 Very High Very High Very High
Disease 4 90.16 High High
INFLAMMATION 5 86.60 High High
Pancreatitis 5 75.00 Quite High
Mouth Cancer 18 60.64 Quite High
Toxicity 3 21.48 Low Low
Appetite Loss 3 20.56 Low Low
Gastroenteritis 6 12.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ratio CD4+/CD8+ was significantly lowered.
Negative_regulation (lowered) of CD8
1) Confidence 0.24 Published 2009 Journal Int. Immunopharmacol. Section Abstract Doc Link 19189865 Disease Relevance 0.17 Pain Relevance 1.04
The present study confirms the decrease in the CD4+/CD8+ ratio with increasing tumor burden.
Negative_regulation (decrease) of CD8 associated with cancer
2) Confidence 0.11 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.75 Pain Relevance 0.04
SD rats with SCCs had decreased CD4+/CD8+ ratios, which were associated with a greater tumor load.
Negative_regulation (decreased) of CD8 associated with cancer and skin cancer
3) Confidence 0.11 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.83 Pain Relevance 0.21
We explain the decreasing CD4+/CD8+ ratio as predominantly due to a decrease of CD4+ T cells as the tumor progresses.
Negative_regulation (decreasing) of CD8 in T cells associated with cancer
4) Confidence 0.11 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.88 Pain Relevance 0.03
Among the infiltrating lymphocytes, CD4+ cells dominated, but during the chronic process there was an increase of CD8+ cells, resulting in a reduced CD4/CD8 ratio.
Negative_regulation (reduced) of CD8 in lymphocytes
5) Confidence 0.08 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11508663 Disease Relevance 0.45 Pain Relevance 0.45

General Comments

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