INT97623

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 3.81
Pain Relevance 8.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Adc)
Anatomy Link Frequency
brain 2
ventricles 1
liver 1
aorta 1
median nerve 1
Adc (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 12 99.82 Very High Very High Very High
imagery 180 99.74 Very High Very High Very High
Morphine 36 99.40 Very High Very High Very High
antagonist 3 99.36 Very High Very High Very High
withdrawal 24 99.20 Very High Very High Very High
antidepressant 7 98.36 Very High Very High Very High
ischemia 23 97.64 Very High Very High Very High
cytokine 8 97.52 Very High Very High Very High
fluoxetine 2 95.96 Very High Very High Very High
tolerance 13 89.20 High High
Disease Link Frequency Relevance Heat
Opiate Addiction 6 99.38 Very High Very High Very High
Edema 20 98.84 Very High Very High Very High
Status Epilepticus 1 98.56 Very High Very High Very High
Leukoencephalopathies 2 98.32 Very High Very High Very High
Cv Unclassified Under Development 14 98.24 Very High Very High Very High
Injury 12 96.68 Very High Very High Very High
Brain Injury 18 96.40 Very High Very High Very High
Hypoxia 3 95.76 Very High Very High Very High
Hemorrhage 6 92.00 High High
Hydrocephalus 43 81.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure of rats to morphine for three days significantly decreases the activity of ADC and the levels of agmatine in rat liver, kidney, brain, aorta and intestine with no changes in agmatinase activity.
Negative_regulation (decreases) of ADC in kidney associated with morphine
1) Confidence 0.56 Published 2002 Journal Life Sci. Section Abstract Doc Link 12137915 Disease Relevance 0.09 Pain Relevance 0.93
The precipitation of withdrawal syndrome by injecting naloxone further decreases ADC activity and agmatine levels in these tissues.
Negative_regulation (decreases) of ADC associated with narcan and withdrawal
2) Confidence 0.49 Published 2002 Journal Life Sci. Section Abstract Doc Link 12137915 Disease Relevance 0.10 Pain Relevance 0.93
In the other two, small hyperintense foci on diffusion-weighted images with decreased ADC were seen within the vasogenic edema.
Negative_regulation (decreased) of ADC
3) Confidence 0.37 Published 2001 Journal Acad Radiol Section Body Doc Link 11508753 Disease Relevance 0.12 Pain Relevance 0
We observed a difference between the CSA and ADC, but not the FA, of the median nerve at the distal forearm and proximal carpal tunnel levels.


Negative_regulation (difference) of ADC in median nerve
4) Confidence 0.33 Published 2009 Journal Skeletal Radiol. Section Body Doc Link 19132371 Disease Relevance 0 Pain Relevance 0
Conversely, prior administration of I(1) receptor antagonist, efaroxan (1 mg/kg, ip), I(2) receptor antagonist, idazoxan (0.25 mg/kg, ip) and arginine decarboxylase inhibitor, d-arginine (100 mg/kg, ip) blocked the antidepressant like effect of paroxetine (10 mg/kg, ip) and fluoxetine (20 mg/kg, ip).
Negative_regulation (inhibitor) of arginine decarboxylase associated with antidepressant, antagonist and fluoxetine
5) Confidence 0.27 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19589348 Disease Relevance 0.05 Pain Relevance 0.93
Acute ADC decrease is not specific of ischemic insult and has been described in both experimental and human traumatic brain injury [14,15].
Negative_regulation (decrease) of ADC in brain associated with brain injury
6) Confidence 0.21 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2827391 Disease Relevance 0.80 Pain Relevance 0.08
These lesions appeared hyperintense on T2WI within the first hour after surgery, with an early mass effect and reduced ADC (Figure 1A).
Negative_regulation (reduced) of ADC
7) Confidence 0.21 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2827391 Disease Relevance 0.15 Pain Relevance 0.24
MCA electrocoagulation (group D) induced an ischemic lesion in the frontoparietal cortex with reduced ADC on day 0 (n = 6/6).
Negative_regulation (reduced) of ADC in cortex
8) Confidence 0.21 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2827391 Disease Relevance 0.19 Pain Relevance 0.21
Incubation of astrocytes and RAW 264.7 cells with LPS/cytokines for 2 hours resulted in an increase in arginine decarboxylase (ADC) activity, whereas longer-term incubation (12-17 hours) lowered ADC activity.
Negative_regulation (lowered) of ADC in RAW 264 associated with cytokine
9) Confidence 0.20 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028566 Disease Relevance 0.23 Pain Relevance 0.28
Exposure of rats to morphine for three days significantly decreases the activity of ADC and the levels of agmatine in rat liver, kidney, brain, aorta and intestine with no changes in agmatinase activity.
Negative_regulation (decreases) of ADC in liver associated with morphine
10) Confidence 0.19 Published 2002 Journal Life Sci. Section Abstract Doc Link 12137915 Disease Relevance 0.09 Pain Relevance 0.93
Exposure of rats to morphine for three days significantly decreases the activity of ADC and the levels of agmatine in rat liver, kidney, brain, aorta and intestine with no changes in agmatinase activity.
Negative_regulation (decreases) of ADC in intestine associated with morphine
11) Confidence 0.19 Published 2002 Journal Life Sci. Section Abstract Doc Link 12137915 Disease Relevance 0.09 Pain Relevance 0.93
Exposure of rats to morphine for three days significantly decreases the activity of ADC and the levels of agmatine in rat liver, kidney, brain, aorta and intestine with no changes in agmatinase activity.
Negative_regulation (decreases) of ADC in aorta associated with morphine
12) Confidence 0.19 Published 2002 Journal Life Sci. Section Abstract Doc Link 12137915 Disease Relevance 0.09 Pain Relevance 0.93
Exposure of rats to morphine for three days significantly decreases the activity of ADC and the levels of agmatine in rat liver, kidney, brain, aorta and intestine with no changes in agmatinase activity.
Negative_regulation (decreases) of ADC in brain associated with morphine
13) Confidence 0.19 Published 2002 Journal Life Sci. Section Abstract Doc Link 12137915 Disease Relevance 0.09 Pain Relevance 0.93
Regional analysis was conducted (on coronal sections) using the b0 (T2-weighted image), ADC, FA maps and the following DTI thresholds; decreased ADC < 1 SD of the contralateral (CL) hemisphere and or increased ADC > 1SD of CL hemisphere (entire extent) and increased b0 (T2-weighted signal intensity) to insure exclusion of the ventricles and to account for the changing nature of the ADC/FA during the 21 day experimental course.
Negative_regulation (decreased) of ADC in ventricles associated with imagery
14) Confidence 0.16 Published 2007 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2577937 Disease Relevance 0.07 Pain Relevance 0.24
Interestingly, however, we observed decreased ADC values in a periventricular rim in the parietal region in two patients.
Negative_regulation (decreased) of ADC in parietal
15) Confidence 0.07 Published 2009 Journal Neuroradiology Section Body Doc Link PMC2744817 Disease Relevance 0.39 Pain Relevance 0.04
Incubation of astrocytes and RAW 264.7 cells with LPS/cytokines for 2 hours resulted in an increase in arginine decarboxylase (ADC) activity, whereas longer-term incubation (12-17 hours) lowered ADC activity.
Negative_regulation (lowered) of ADC in astrocytes associated with cytokine
16) Confidence 0.07 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028566 Disease Relevance 0.23 Pain Relevance 0.28
It has been proposed that decreased ADC values may result from cell swelling, loss of extracellular volume and reduction in transmembrane water movement [54].
Negative_regulation (decreased) of ADC associated with edema
17) Confidence 0.04 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 1.02 Pain Relevance 0.23

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