INT97624

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 13
Total Number 16
Disease Relevance 5.56
Pain Relevance 4.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Adc)
Anatomy Link Frequency
astrocytes 3
RAW 264 2
white matter 2
ventricles 1
Lateral 1
Adc (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 12 100.00 Very High Very High Very High
cytokine 16 99.44 Very High Very High Very High
Glutamate 10 99.44 Very High Very High Very High
opiate 4 98.52 Very High Very High Very High
imagery 291 98.44 Very High Very High Very High
Serotonin 8 96.84 Very High Very High Very High
gABA 4 92.76 High High
cva 36 91.60 High High
Morphine 8 88.44 High High
Hippocampus 24 88.00 High High
Disease Link Frequency Relevance Heat
Stroke 129 99.72 Very High Very High Very High
Hydrocephalus 129 98.88 Very High Very High Very High
Stress 8 96.72 Very High Very High Very High
Oxidative Phosphorylation Disease 50 91.76 High High
Intracranial Hypertension 21 91.60 High High
Demyelinating Disease 38 87.20 High High
Congenital Anomalies 57 86.68 High High
Injury 16 86.32 High High
Cv Unclassified Under Development 13 84.56 Quite High
Brain Hemorrhage 4 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In four other patients, it primarily showed iso- or slightly hyperintense lesions with increased ADC, suggesting vasogenic edema.
Positive_regulation (increased) of ADC
1) Confidence 0.69 Published 2001 Journal Acad Radiol Section Body Doc Link 11508753 Disease Relevance 0.14 Pain Relevance 0
Fourthly, ADC patients should only be recruited into future anti-retroviral trials if they have active virally mediated ADC.
Positive_regulation (mediated) of ADC
2) Confidence 0.37 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0 Pain Relevance 0
Incubation of astrocytes and RAW 264.7 cells with LPS/cytokines for 2 hours resulted in an increase in arginine decarboxylase (ADC) activity, whereas longer-term incubation (12-17 hours) lowered ADC activity.
Positive_regulation (increase) of arginine decarboxylase in RAW 264 associated with cytokine
3) Confidence 0.28 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028566 Disease Relevance 0.24 Pain Relevance 0.29
Incubation of astrocytes and RAW 264.7 cells with LPS/cytokines for 2 hours resulted in an increase in arginine decarboxylase (ADC) activity, whereas longer-term incubation (12-17 hours) lowered ADC activity.
Positive_regulation (increase) of ADC in RAW 264 associated with cytokine
4) Confidence 0.28 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028566 Disease Relevance 0.24 Pain Relevance 0.29
Median nerve CSA, ADC, and FA were analyzed at standardized anatomic levels.
Spec (analyzed) Positive_regulation (Median nerve) of ADC in Median nerve
5) Confidence 0.17 Published 2009 Journal Skeletal Radiol. Section Body Doc Link 19132371 Disease Relevance 0 Pain Relevance 0
Regional analysis was conducted (on coronal sections) using the b0 (T2-weighted image), ADC, FA maps and the following DTI thresholds; decreased ADC < 1 SD of the contralateral (CL) hemisphere and or increased ADC > 1SD of CL hemisphere (entire extent) and increased b0 (T2-weighted signal intensity) to insure exclusion of the ventricles and to account for the changing nature of the ADC/FA during the 21 day experimental course.
Positive_regulation (increased) of ADC in ventricles associated with imagery
6) Confidence 0.17 Published 2007 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2577937 Disease Relevance 0.08 Pain Relevance 0.22
In vivo ADC within the infarct was significantly increased after stroke.
Positive_regulation (increased) of ADC associated with stroke
7) Confidence 0.17 Published 2007 Journal The Open Neuroimaging Journal Section Abstract Doc Link PMC2577937 Disease Relevance 0.60 Pain Relevance 0.12
The increase in both dopamine ADC activity and glutamate concentrations was also associated with greater oxidative stress on the mitochondrial and post-mitochondrial fractions in cells.
Positive_regulation (increase) of dopamine ADC associated with stress, glutamate and dopamine
8) Confidence 0.16 Published 2010 Journal Comp. Biochem. Physiol. C Toxicol. Pharmacol. Section Abstract Doc Link 20398796 Disease Relevance 0.17 Pain Relevance 1.01
However, dopamine-sensitive ADC activity was readily activated, indicating the potential effect on opiate signaling.
Positive_regulation (activated) of ADC associated with dopamine and opiate
9) Confidence 0.14 Published 2010 Journal Comp. Biochem. Physiol. C Toxicol. Pharmacol. Section Abstract Doc Link 20398796 Disease Relevance 0.16 Pain Relevance 1.07
Within the abnormal white matter, ADC, a measure for water diffusivity, irrespective of direction, was increased in patients, and FA, a measure for the degree of diffusion anisotropy, was decreased.
Positive_regulation (increased) of ADC in white matter
10) Confidence 0.11 Published 2009 Journal Neuroradiology Section Body Doc Link PMC2744817 Disease Relevance 0.62 Pain Relevance 0.04
Incubation of astrocytes and RAW 264.7 cells with LPS/cytokines for 2 hours resulted in an increase in arginine decarboxylase (ADC) activity, whereas longer-term incubation (12-17 hours) lowered ADC activity.
Positive_regulation (increase) of arginine decarboxylase in astrocytes associated with cytokine
11) Confidence 0.09 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028566 Disease Relevance 0.24 Pain Relevance 0.29
Incubation of astrocytes and RAW 264.7 cells with LPS/cytokines for 2 hours resulted in an increase in arginine decarboxylase (ADC) activity, whereas longer-term incubation (12-17 hours) lowered ADC activity.
Positive_regulation (increase) of ADC in astrocytes associated with cytokine
12) Confidence 0.09 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15028566 Disease Relevance 0.24 Pain Relevance 0.29
High values of ADC were observed, and both FA and MTR were attenuated.


Positive_regulation (values) of ADC
13) Confidence 0.08 Published 2009 Journal Neuroradiology Section Abstract Doc Link PMC2744817 Disease Relevance 0.59 Pain Relevance 0.59
Other authors present similar initially non-significant decreases in periventricular white matter ADC values one day after kaolin injection followed by significant increases in periventricular ADC at eight days [54].
Positive_regulation (increases) of ADC in white matter
14) Confidence 0.06 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 1.07 Pain Relevance 0.32
Lateral ventricular volume was significantly increased over control at all time points after induction and the periventricular apparent diffusion coefficient (ADC) value significantly increased after one and two weeks of hydrocephalus.
Positive_regulation (increased) of ADC in Lateral associated with hydrocephalus
15) Confidence 0.04 Published 2010 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2987763 Disease Relevance 0.39 Pain Relevance 0.08
At two weeks, increased abundance of AQP4 expressed in astrocyte processes of the periventricular region was found, together with significant elevated ADC values.
Positive_regulation (elevated) of ADC in astrocyte
16) Confidence 0.04 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.78 Pain Relevance 0.27

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