INT97625

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1)
cell-cell signaling (GNRH1)
Anatomy Link Frequency
pituitary 2
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 1 77.68 Quite High
Opioid 3 68.80 Quite High
antagonist 3 67.20 Quite High
agonist 16 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 43 92.00 High High
Impaired Glucose Tolerance 1 77.68 Quite High
Polycystic Ovary Syndrome 5 75.00 Quite High
Obesity 3 71.64 Quite High
Syndrome 2 71.20 Quite High
Apoptosis 6 69.12 Quite High
Cancer 10 67.68 Quite High
Hyperplasia 1 51.96 Quite High
Disease 8 5.00 Very Low Very Low Very Low
Metastasis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic exposure to LHRH ultimately suppressed testosterone by desensitizing pituitary cells through down-regulation of the LHRH receptors (Van Loenen et al 2002).
Negative_regulation (suppressed) of Regulation (regulation) of LHRH in pituitary
1) Confidence 0.39 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504071 Disease Relevance 0.39 Pain Relevance 0
The naltrexone treatment significantly reduced the insulin response to OGTT and the LH response to GnRH bolus, whereas it did not affect the FSH and LH pulsatility patterns.
Negative_regulation (reduced) of Regulation (response) of GnRH
2) Confidence 0.36 Published 2001 Journal J. Endocrinol. Invest. Section Abstract Doc Link 11508781 Disease Relevance 0.50 Pain Relevance 0.27

General Comments

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