INT97638

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.89
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL16) extracellular region (CCL16) cell-cell signaling (CCL16)
Anatomy Link Frequency
monocyte 2
retina 1
uterine 1
skin 1
CCL16 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 405 100.00 Very High Very High Very High
endometriosis 210 99.84 Very High Very High Very High
Inflammation 110 93.76 High High
COX-2 inhibitor 12 85.60 High High
cytokine 51 84.64 Quite High
cINOD 5 81.84 Quite High
dexamethasone 8 79.92 Quite High
aspirin 5 75.00 Quite High
Inflammatory mediators 3 75.00 Quite High
diclofenac 4 74.24 Quite High
Disease Link Frequency Relevance Heat
Endometriosis 243 99.84 Very High Very High Very High
Retinal Diseases 2 97.28 Very High Very High Very High
Capsule Opacification 102 96.08 Very High Very High Very High
Injury 3 95.08 Very High Very High Very High
INFLAMMATION 124 93.76 High High
Apoptosis 32 84.16 Quite High
Death 5 75.12 Quite High
Choristoma 24 69.12 Quite High
Disease 40 66.48 Quite High
Cataract 50 66.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The staining pattern in some glands was predominantly apical (Figures 4A–C) suggesting secretion of the chemokine into the uterine lumen.
Localization (secretion) of chemokine in uterine associated with chemokine
1) Confidence 0.66 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.55 Pain Relevance 0.47
Understanding the pathophysiology of chemokine secretion in endometriosis is important as it may offer a novel area of therapeutic intervention.
Localization (secretion) of chemokine associated with endometriosis and chemokine
2) Confidence 0.58 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1884154 Disease Relevance 0.90 Pain Relevance 0.55
Understanding the pathophysiology of chemokine secretion in endometriosis may offer a novel area of therapeutic intervention.
Localization (secretion) of chemokine associated with endometriosis and chemokine
3) Confidence 0.58 Published 2007 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1884154 Disease Relevance 0.50 Pain Relevance 0.40
In parallel experiments involving human colonic mucosa ex vivo, LXA(4)potently attenuated TNF-alpha-stimulated release of the C-X-C chemokine IL-8, and the C-C chemokines monocyte-chemoattractant protein-1 (MCP-1) and RANTES.
Localization (release) of chemokine IL-8 in monocyte associated with chemokine
4) Confidence 0.24 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11509622 Disease Relevance 0.44 Pain Relevance 0.51
There was a significant (p<0.001) delay in LEC migration in both the celecoxib and rofecoxib treatments compared to the controls (Figure 3B).
Localization (migration) of LEC
5) Confidence 0.22 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.53 Pain Relevance 0
Unfortunately, in vivo concentrations high enough to inhibit LEC proliferation, whether as a single application or as a sustained release, have resulted in toxic effects to the corneal endothelial cells, iris, ciliary body and/or retina [61].
Localization (release) of LEC in retina
6) Confidence 0.19 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.87 Pain Relevance 0.19
In humans, there are 27 CC chemokines, most of which including CCL2, CCL7, CCL11, CCL8, CCL13, CCL1, CCL5, CCL16, CCL14, CCL15, CCL23, CCL18, CCL3 and CCL4, respectively, are encoded as a cluster within chromosome 17q11.
Localization (including) of CCL16 associated with chemokine
7) Confidence 0.18 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.51 Pain Relevance 0.72
A couple of years ago it was demonstrated by in vitro experiments that human LEC constitutively secrete CCL21 at their basal side [25], and more recently Weninger et al. found expression of this chemokine by LEC from normal human skin using immunofluorescence staining [13].
Localization (secrete) of LEC in skin associated with chemokine
8) Confidence 0.15 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.35 Pain Relevance 0.20
This study investigates chemokine secretion induced by co-culture of hRPE cells and monocytes and illustrates the roles of p38 kinase, ERK, JNK/SAPK and NF-kappaB-inducing kinase signaling pathways for hRPE IL-8 and MCP-1 secretion induced in hRPE by co-culture with monocytes.
Localization (secretion) of chemokine in monocytes associated with chemokine
9) Confidence 0.05 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.10 Pain Relevance 0.09
Chemokine secretion was completely blocked by simultaneous administration of U0126 and SB203580.
Localization (secretion) of Chemokine associated with chemokine
10) Confidence 0.05 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.15 Pain Relevance 0.35
We quantitated chemokine protein secretion in culture supernates using commercially available, highly specific and sensitive ELISA kits from R&D systems (Minneapolis, MN) and Biosource International (Camarillo, CA) according to the instructions supplied by the manufacturer.


Localization (secretion) of chemokine associated with chemokine
11) Confidence 0.01 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC153847 Disease Relevance 0 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox