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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.14
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adrb3) plasma membrane (Adrb3) nucleus (Adrb3)
signal transducer activity (Adrb3)
Anatomy Link Frequency
plasma 1
autonomic 1
heart 1
Adrb3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 15 100.00 Very High Very High Very High
Clonidine 9 100.00 Very High Very High Very High
agonist 3 100.00 Very High Very High Very High
Multiple sclerosis 12 97.84 Very High Very High Very High
noradrenaline 4 93.32 High High
cINOD 1 90.40 High High
Inflammation 3 88.88 High High
Visceral pain 4 88.84 High High
Codeine 1 82.92 Quite High
Pain 4 65.52 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 1 100.00 Very High Very High Very High
Hypertension 2 98.32 Very High Very High Very High
Demyelinating Disease 12 97.84 Very High Very High Very High
Nociception 1 96.56 Very High Very High Very High
Pressure And Volume Under Development 1 91.52 High High
INFLAMMATION 4 90.00 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 88.84 High High
Hypotension 4 88.40 High High
Cough 5 87.20 High High
Bronchitis 2 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinical assessment of beta-adrenoceptor antagonism is more valuable than plasma concentration determinations in evaluating the adequacy of the dose of a particular beta-adrenoceptor antagonist.
Gene_expression (antagonism) of beta-adrenoceptor in plasma associated with antagonist
1) Confidence 0.62 Published 1987 Journal Clin Pharmacokinet Section Abstract Doc Link 2891461 Disease Relevance 0.38 Pain Relevance 0.20
Concomitant administration of the alpha 2-adrenoceptor agonist, clonidine, and the alpha 1- and non-selective beta-adrenoceptor antagonist, labetalol, was studied in 12 hypertensive outpatients treated with thiazide diuretics.
Gene_expression (administration) of beta-adrenoceptor associated with antagonist, hypertension, agonist and clonidine
2) Confidence 0.62 Published 1983 Journal Acta Med Scand Section Abstract Doc Link 6624543 Disease Relevance 0.17 Pain Relevance 0.55
The above findings can be explained by a depressant effect on automaticity and tension development in the heart, suggesting a beta-adrenoceptor blocking action produced by the garlic dialysate.
Gene_expression (produced) of beta-adrenoceptor in heart
3) Confidence 0.58 Published 1992 Journal J Ethnopharmacol Section Abstract Doc Link 1434688 Disease Relevance 0 Pain Relevance 0
In addition, we found that Bakumondo-to itself stimulated phosphatidylcholine secretion and increased beta-adrenoceptor gene expression in rat alveolar type II cells.
Gene_expression (expression) of beta-adrenoceptor gene
4) Confidence 0.41 Published 2003 Journal Yakugaku Zasshi Section Abstract Doc Link 14689863 Disease Relevance 0.77 Pain Relevance 0.11
Using a conditioned place aversion (CPA) test, we found that intra-vBNST injection of timolol, a beta-adrenoceptor antagonist, dose-dependently attenuated the acetic acid-induced CPA without reducing nociceptive behaviors.
Gene_expression (injection) of beta-adrenoceptor in CPA associated with nociception and antagonist
5) Confidence 0.38 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 18793681 Disease Relevance 0.16 Pain Relevance 0.48
These results further supported the bradycardia-inducing and beta-adrenoceptor antagonistic properties of DDA in vivo.
Gene_expression (bradycardia-inducing) of beta-adrenoceptor associated with heart rate under development
6) Confidence 0.27 Published 1998 Journal Pharmacol. Res. Section Abstract Doc Link 9990649 Disease Relevance 0.26 Pain Relevance 0.04
Possible involvement that the pressor and positive chronotropic effects of endothelin-3 (ET-3) administered intracerebroventricularly (i.c.v.) participate in the central beta-adrenoceptor has been studied in urethane anesthetized rats.
Gene_expression (participate) of beta-adrenoceptor
7) Confidence 0.23 Published 1995 Journal Life Sci. Section Abstract Doc Link 7603307 Disease Relevance 0.09 Pain Relevance 0.03
Combined alpha- and beta-adrenoceptor blockade (with phentolamine and nadolol) produced significant attenuation of the pressor and tachycardic responses to R-alpha-methylhistamine in pithed rats.
Gene_expression (produced) of beta-adrenoceptor
8) Confidence 0.22 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7907986 Disease Relevance 0 Pain Relevance 0.19
On the other hand, several groups of effective drugs were available in Estonia only in limited amounts, including the histamine (H2) receptor antagonists, hormonal contraceptives, beta-adrenoceptor antagonists, angiotensin converting enzyme inhibitors, and cephalosporins.
Gene_expression (antagonists) of beta-adrenoceptor associated with antagonist
9) Confidence 0.07 Published 1992 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 1606997 Disease Relevance 0.34 Pain Relevance 0.19
High beta-adrenoceptor density on peripheral blood mononuclear cells in progressive multiple sclerosis: a manifestation of autonomic dysfunction?
Gene_expression (density) of beta-adrenoceptor in autonomic associated with multiple sclerosis
10) Confidence 0.02 Published 1994 Journal Acta Neurol. Scand. Section Title Doc Link 7892755 Disease Relevance 1.72 Pain Relevance 0.55

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