INT9766

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Context Info
Confidence 0.47
First Reported 1992
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.40
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ada) extracellular space (Ada) cell adhesion (Ada)
plasma membrane (Ada) lysosome (Ada) cytoplasm (Ada)
Anatomy Link Frequency
spinal 1
brain 1
Ada (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 34 100.00 Very High Very High Very High
antinociception 14 99.00 Very High Very High Very High
opioid receptor 2 97.60 Very High Very High Very High
agonist 3 96.56 Very High Very High Very High
Hyperalgesia 1 95.76 Very High Very High Very High
Opioid 5 93.84 High High
tail-flick 1 76.32 Quite High
MU agonist 1 75.00 Quite High
intrathecal 1 66.52 Quite High
anticonvulsant 1 66.12 Quite High
Disease Link Frequency Relevance Heat
Amnesia 1 96.24 Very High Very High Very High
Hyperalgesia 1 95.76 Very High Very High Very High
Convulsion 3 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results confirm different physiologic roles for adenosine kinase and adenosine deaminase in spinal purinergic systems. 5'-NH2dAdo interactions with opioid receptor-selective agonists demonstrate significant, but heterogeneous interactions between endogenous adenosine and opioid spinal systems mediating antinociception.
Positive_regulation (roles) of adenosine deaminase in spinal associated with antinociception, adenocard, agonist, opioid receptor and opioid
1) Confidence 0.47 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7698211 Disease Relevance 0 Pain Relevance 1.72
Biochemical analysis revealed that chronic treatment with PTZ significantly increased lipid peroxidation (malondialdehyde levels), nitrite (NO(2-) levels), adenosine deaminase (ADA) and total RNA levels and decreased catalase, reduced glutathione (GSH) levels in brain homogenates, and a depletion of adrenal ascorbic acid.
Positive_regulation (increased) of ADA in brain associated with adenocard
2) Confidence 0.43 Published 2007 Journal Fundam Clin Pharmacol Section Abstract Doc Link 18034659 Disease Relevance 0.40 Pain Relevance 0.54
Relative involvement of adenosine deaminase and adenosine kinase in antinociception induced by endogenous adenosine was investigated.
Spec (investigated) Positive_regulation (involvement) of adenosine deaminase associated with antinociception and adenocard
3) Confidence 0.36 Published 1992 Journal Life Sci. Section Abstract Doc Link 1435056 Disease Relevance 0 Pain Relevance 0.84

General Comments

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