INT97665

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.72
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
tail 2
neurons 2
Pnoc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 16 100.00 Very High Very High Very High
narcan 4 99.80 Very High Very High Very High
tail-flick 2 99.20 Very High Very High Very High
analgesia 5 98.84 Very High Very High Very High
Opioid 5 98.64 Very High Very High Very High
Raphe 2 98.60 Very High Very High Very High
MU agonist 1 96.40 Very High Very High Very High
Spinal cord 1 91.84 High High
opioid receptor 1 91.24 High High
Neuropeptide 3 86.60 High High
Disease Link Frequency Relevance Heat
Nociception 5 100.00 Very High Very High Very High
Bordatella Infection 2 98.36 Very High Very High Very High
Hyperalgesia 1 81.72 Quite High
Dysmenorrhea 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More precisely, supraspinal Nocistatin by itself had no significative effect on nociception and opioid analgesia in the tail flick test but, at the dose of 0.5ng/rat, it reversed the nociceptive effect of Nociceptin and also the antagonistic effect of Nociceptin against analgesia caused by the selective opioid agonists: DAMGO, DPDPE, Deltorphin II and U50 488H.
Negative_regulation (reversed) of Regulation (effect) of Nociceptin in tail associated with nociception, mu agonist, orphanin, tail-flick, opioid and analgesia
1) Confidence 0.43 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16006036 Disease Relevance 0.45 Pain Relevance 1.64
Tetraethylammonium and paxilline reduced the contraction-inhibiting effect of PNOC and naloxone to approximately 10% and 15%, respectively.
Negative_regulation (reduced) of Regulation (effect) of PNOC associated with narcan
2) Confidence 0.38 Published 2010 Journal Biol. Reprod. Section Abstract Doc Link 20237332 Disease Relevance 0.26 Pain Relevance 0.33
The activities of these analogues were evaluated by their ability to both inhibit adenylate cyclase in NPFF2 receptor transfected CHO cells and to reverse the effect of nociceptin on acutely dissociated rat dorsal raphe neurons.
Negative_regulation (reverse) of Regulation (effect) of nociceptin in neurons associated with orphanin and raphe
3) Confidence 0.07 Published 2001 Journal Peptides Section Abstract Doc Link 11514031 Disease Relevance 0 Pain Relevance 0.32

General Comments

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