INT9767

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Context Info
Confidence 0.55
First Reported 1981
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.06
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ada) extracellular space (Ada) cell adhesion (Ada)
plasma membrane (Ada) lysosome (Ada) cytoplasm (Ada)
Anatomy Link Frequency
spinal 1
tail 1
Ada (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 47 100.00 Very High Very High Very High
agonist 4 99.92 Very High Very High Very High
Analgesic 3 99.58 Very High Very High Very High
opioid receptor 4 99.16 Very High Very High Very High
MU agonist 2 98.72 Very High Very High Very High
tail-flick 1 97.96 Very High Very High Very High
antinociception 22 97.80 Very High Very High Very High
Opioid 10 95.20 Very High Very High Very High
intrathecal 2 91.88 High High
narcan 1 84.24 Quite High
Disease Link Frequency Relevance Heat
Hypothermia 1 58.72 Quite High
Injury 2 50.00 Quite Low
Enteropathy 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adenosine kinase and adenosine deaminase inhibition modulate spinal adenosine- and opioid agonist-induced antinociception in mice.
Negative_regulation (inhibition) of adenosine deaminase in spinal associated with antinociception, mu agonist and adenocard
1) Confidence 0.55 Published 1994 Journal Eur. J. Pharmacol. Section Title Doc Link 7698211 Disease Relevance 0 Pain Relevance 1.69
Inhibitors of adenosine deaminase, deoxycoformycin and erythro-9-(2-hydroxy-3nonyl) adenine (EHNA), generally failed to induce antinociception when administered (i.t.) alone or to enhance opioid (i.t.)
Negative_regulation (Inhibitors) of adenosine deaminase associated with antinociception, adenocard and opioid
2) Confidence 0.41 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7698211 Disease Relevance 0 Pain Relevance 1.70
CONCLUSIONS: OGT may prevent IND-induced enteropathy by decreasing ADA which results in the elevation of adenosine.
Negative_regulation (decreasing) of ADA
3) Confidence 0.34 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19319464 Disease Relevance 0 Pain Relevance 0
Papaverine (an adenosine uptake blocker) and erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA: an adenosine deaminase inhibitor) potentiated the effect of ADO.
Negative_regulation (inhibitor) of adenosine deaminase associated with adenocard
4) Confidence 0.34 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6895875 Disease Relevance 0.06 Pain Relevance 0.63
Antinociception induced by 5'-amino 5'-deoxyadenosine (5'-ADAdo; an adenosine kinase inhibitor) and deoxycoformycin (dCF; an adenosine deaminase inhibitor) administered i.t. was determined using the mouse tail-flick assay.
Negative_regulation (inhibitor) of adenosine deaminase in tail associated with antinociception, adenocard and tail-flick
5) Confidence 0.30 Published 1992 Journal Life Sci. Section Abstract Doc Link 1435056 Disease Relevance 0 Pain Relevance 1.04

General Comments

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