INT97674

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 70
Total Number 77
Disease Relevance 27.71
Pain Relevance 51.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) extracellular region (Calca) nucleus (Calca)
intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
sensory neurons 16
neurons 16
skin 8
heart 8
nerve 8
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 794 100.00 Very High Very High Very High
Calcitonin gene-related peptide 350 100.00 Very High Very High Very High
Inflammation 250 100.00 Very High Very High Very High
calcitonin gene related peptide 149 100.00 Very High Very High Very High
substance P 138 100.00 Very High Very High Very High
Neuropeptide 112 100.00 Very High Very High Very High
Morphine 1003 99.98 Very High Very High Very High
Serotonin 79 99.98 Very High Very High Very High
nociceptor 192 99.88 Very High Very High Very High
Nerve growth factor 120 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 367 100.00 Very High Very High Very High
INFLAMMATION 277 100.00 Very High Very High Very High
Osteogenic Sarcomas 19 100.00 Very High Very High Very High
Ganglion Cysts 150 99.76 Very High Very High Very High
Osteoarthritis 15 99.72 Very High Very High Very High
Coronary Artery Disease 24 99.60 Very High Very High Very High
Targeted Disruption 267 99.56 Very High Very High Very High
Pain 476 99.06 Very High Very High Very High
Hyperalgesia 90 98.28 Very High Very High Very High
Cough 20 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The substantial increase of CGRP release evoked by noxious heat (47 degrees C) was diminished under muscarine by >50% in the WT and M4 KO animals but remained unaltered in the M2 KO mice.
Positive_regulation (increase) of Localization (release) of CGRP associated with calcitonin gene-related peptide
1) Confidence 0.69 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12045234 Disease Relevance 0.36 Pain Relevance 0.54
In the second, neurochemical approach, the heat-induced cutaneous release of calcitonin gene-related peptide (CGRP) was investigated to gain comparative data on the neurosecretory (vasodilatory) functions of the primary afferent neurons.
Spec (investigated) Positive_regulation (induced) of Localization (release) of calcitonin gene-related peptide in afferent neurons associated with calcitonin gene-related peptide
2) Confidence 0.69 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12045234 Disease Relevance 0.36 Pain Relevance 0.55
RESULTS: SIF at pH 5.7 and 5.2 caused significant increases in CGRP release in TRPV1+/+ but not in mice lacking the TRPV1 receptor.
Positive_regulation (increases) of Localization (release) of CGRP
3) Confidence 0.66 Published 2005 Journal Cardiovasc. Res. Section Body Doc Link 15639479 Disease Relevance 0 Pain Relevance 0
These results indicate that the deletion of the Y1 receptor causes increased release and compensatory increased synthesis of calcitonin gene-related peptide and substance P in dorsal root ganglion neurons.
Positive_regulation (causes) of Localization (release) of calcitonin in neurons associated with ganglion cysts, root ganglion neuron, substance p and calcitonin gene-related peptide
4) Confidence 0.64 Published 2006 Journal Neuroscience Section Abstract Doc Link 16564642 Disease Relevance 1.03 Pain Relevance 1.22
These results indicate that the deletion of the Y1 receptor causes increased release and compensatory increased synthesis of calcitonin gene-related peptide and substance P in dorsal root ganglion neurons.
Positive_regulation (increased) of Localization (release) of calcitonin in neurons associated with ganglion cysts, root ganglion neuron, substance p and calcitonin gene-related peptide
5) Confidence 0.64 Published 2006 Journal Neuroscience Section Abstract Doc Link 16564642 Disease Relevance 1.03 Pain Relevance 1.21
Graded heat-induced CGRP release depended entirely on extracellular calcium and partly on TRPV1; knockout mice showed 60% less CGRP release at 45 degrees C (for 5 min) than wild-types.
Positive_regulation (induced) of Localization (release) of CGRP associated with targeted disruption and calcitonin gene-related peptide
6) Confidence 0.64 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19473241 Disease Relevance 0.52 Pain Relevance 0.64
In this study we demonstrate that similar functions, including capsaicin-induced CGRP release, are to be found in the desheathed sciatic nerve of the mouse.
Positive_regulation (induced) of Localization (release) of CGRP in sciatic nerve associated with qutenza, sciatic nerve and calcitonin gene-related peptide
7) Confidence 0.62 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183508 Disease Relevance 0 Pain Relevance 0.79
The postischemic anti-inflammatory effects of ethanol consumption were abolished by administration of a specific CGRP receptor antagonist [CGRP-(8-37)] or after sensory nerve neurotransmitter depletion using capsaicin administered 4 days before ethanol ingestion, which initially induces rapid release of CGRP from sensory nerves, thereby depleting stored neuropeptide.
Positive_regulation (induces) of Localization (release) of CGRP in sensory nerves associated with neurotransmitter, qutenza, inflammation, antagonist, neuropeptide and calcitonin gene-related peptide
8) Confidence 0.61 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16143644 Disease Relevance 0.38 Pain Relevance 1.13
Capsaicin activates vanilloid receptor-1, thereby increasing the release of calcitonin gene-related peptide (CGRP) from sensory neurons, and CGRP has been shown to increase IGF-I production.
Positive_regulation (increasing) of Localization (release) of calcitonin gene-related peptide in sensory neurons associated with calcitonin gene-related peptide
9) Confidence 0.60 Published 2007 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17569567 Disease Relevance 0.25 Pain Relevance 0.44
Colocalization study showed that the percentages of colocalization of TRPV1 with neurofilament 200 kD (NF200) and calcitonin gene-related peptide (CGRP) but not isolectin B4 (IB4) among DRG neurons in mice with osteosarcoma implantation were increased compared with those in sham mice (from 0.8+/-0.1% to 2.1+/-0.3% for TRPV1 and NF200 and from 21.1+/-1.3% to 26.5+/-0.2% for TRPV1 and CGRP).
Positive_regulation (increased) of Localization (colocalization) of calcitonin gene-related peptide in IB4 associated with osteogenic sarcomas and calcitonin gene-related peptide
10) Confidence 0.60 Published 2007 Journal Neuroscience Section Abstract Doc Link 17656027 Disease Relevance 1.16 Pain Relevance 0.62
Calcitonin gene-related peptide (CGRP) release increased in the central compartment and was mediated by concurrent release of 5-hydroxytryptamine (5-HT) because its release was blocked by a 5-HT4 receptor antagonist.
Positive_regulation (increased) of Localization (release) of CGRP associated with antagonist and calcitonin gene-related peptide
11) Confidence 0.57 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12966154 Disease Relevance 0 Pain Relevance 0.85
Calcitonin gene-related peptide (CGRP) release increased in the central compartment and was mediated by concurrent release of 5-hydroxytryptamine (5-HT) because its release was blocked by a 5-HT4 receptor antagonist.
Positive_regulation (mediated) of Localization (release) of CGRP associated with antagonist and calcitonin gene-related peptide
12) Confidence 0.57 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12966154 Disease Relevance 0 Pain Relevance 0.86
Noxious heat-induced calcitonin gene-related peptide release showed clear deficits (<50%) in TRPV1 deficient skin, but the stimulated calcitonin gene-related peptide release from the isolated skull dura was unaffected.
Positive_regulation (induced) of Localization (release) of calcitonin in skin associated with calcitonin gene-related peptide
13) Confidence 0.51 Published 2005 Journal Neuroscience Section Abstract Doc Link 16165301 Disease Relevance 0.07 Pain Relevance 0.50
The results suggest that mouse heart immersion is more effective than coronary perfusion in measuring stimulated CGRP release from cardial afferents which are widely distributed in the epicardium but rare in deeper myocardial layers.
Positive_regulation (stimulated) of Localization (release) of CGRP in epicardium associated with calcitonin gene-related peptide
14) Confidence 0.50 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16413055 Disease Relevance 0.11 Pain Relevance 0.63
These results suggest that spleen derived factor induced activation of vanilloid receptors and CGRP release may be contributing in the development of hyperalgesia in diabetic mice.
Positive_regulation (activation) of Localization (release) of CGRP in spleen associated with hyperalgesia and diabetes mellitus
15) Confidence 0.50 Published 2008 Journal Yakugaku Zasshi Section Abstract Doc Link 18981706 Disease Relevance 1.53 Pain Relevance 0.79
Osteoarthritic mice exhibit enhanced prostaglandin E2 and unchanged calcitonin gene-related peptide release in a novel isolated knee joint model.
Positive_regulation (enhanced) of Localization (release) of calcitonin in knee joint associated with osteoarthritis and calcitonin gene-related peptide
16) Confidence 0.50 Published 2004 Journal J. Rheumatol. Section Title Doc Link 15468368 Disease Relevance 0.30 Pain Relevance 0.34
In the second, neurochemical approach, the heat-induced cutaneous release of calcitonin gene-related peptide (CGRP) was investigated to gain comparative data on the neurosecretory (vasodilatory) functions of the primary afferent neurons.
Spec (investigated) Positive_regulation (heat-induced) of Localization (release) of CGRP in afferent neurons associated with calcitonin gene-related peptide
17) Confidence 0.50 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12045234 Disease Relevance 0.36 Pain Relevance 0.55
Experiments on capsaicin-induced CGRP release in tissue from CB1-/- mice ruled out a CB1-mediated effect.
Positive_regulation (capsaicin-induced) of Localization (release) of CGRP associated with qutenza and calcitonin gene-related peptide
18) Confidence 0.49 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16553616 Disease Relevance 0.22 Pain Relevance 0.90
When the skin flaps were transferred to the test tube containing 10 mM morphine, the CGRP release increased to 20 ± 5 pg/ml (p = 0.012, Wilcoxon).
Positive_regulation (increased) of Localization (release) of CGRP in tube associated with morphine
19) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2672059 Disease Relevance 0.05 Pain Relevance 1.00
Morphine-induced CGRP release from hindpaw skin
Positive_regulation (induced) of Localization (release) of CGRP in skin associated with morphine
20) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2672059 Disease Relevance 0.18 Pain Relevance 1.30

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