INT97692

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 14.88
Pain Relevance 5.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HDAC9) transcription factor binding (HDAC9) cytoplasm (HDAC9)
Anatomy Link Frequency
IL2R 1
HDAC9 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 457 99.84 Very High Very High Very High
Nav1.2 1 99.52 Very High Very High Very High
Osteoarthritis 221 99.46 Very High Very High Very High
sodium channel 2 99.24 Very High Very High Very High
Inflammation 292 99.12 Very High Very High Very High
agonist 32 99.10 Very High Very High Very High
cytokine 79 98.60 Very High Very High Very High
corticosteroid 28 98.44 Very High Very High Very High
adenocard 2 94.12 High High
Arthritis 40 93.32 High High
Disease Link Frequency Relevance Heat
Apoptosis 90 100.00 Very High Very High Very High
Rheumatoid Arthritis 457 99.84 Very High Very High Very High
Pulmonary Disease 208 99.48 Very High Very High Very High
Frailty 228 99.46 Very High Very High Very High
INFLAMMATION 342 99.12 Very High Very High Very High
Stress 30 98.72 Very High Very High Very High
Repression 15 98.48 Very High Very High Very High
Cancer 185 98.18 Very High Very High Very High
Myelofibrosis 32 97.56 Very High Very High Very High
Nicotine Addiction 58 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Then, as shown by quantitative analysis in Fig. 6, the expression of members in class I HDACs was found to be stable or be slightly reduced during the time period examined, while those in class IIa HDACs were upregulated significantly to different levels.
Positive_regulation (upregulated) of HDAC
1) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942827 Disease Relevance 0.34 Pain Relevance 0.31
In this study, we demonstrated that total nuclear HDAC activity is increased in samples of human RA synovial tissues compared to that in samples of OA and normal subjects.
Positive_regulation (increased) of HDAC associated with rheumatoid arthritis and osteoarthritis
2) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.47 Pain Relevance 0.57
Recent studies on the balance of HAT and HDAC activity in human RA synovial tissue indicated that HDAC activity was significantly decreased in RA synovial tissue compared to osteoarthritis (OA) and normal tissues, thus HDAC/HAT might be strongly shifted toward histone hyperacetylation in RA patients [12].
Positive_regulation (shifted) of HDAC associated with rheumatoid arthritis and osteoarthritis
3) Confidence 0.24 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.99 Pain Relevance 0.34
up-regulated HDAC activity in RASFs, suggesting the downstream role of HDAC in exacerbation of the inflammation, and that the inhibition of HDAC activity results in the suppression of arthritis.
Positive_regulation (up-regulated) of HDAC associated with inflammation and arthritis
4) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.15 Pain Relevance 0.53
In the presence of REST, the CoREST/HDAC2 complex occupied the native Nav1.2 sodium channel gene in chromatin.
Positive_regulation (occupied) of HDAC associated with sodium channel and nav1.2
5) Confidence 0.21 Published 2001 Journal Neuron Section Abstract Doc Link 11516394 Disease Relevance 0.10 Pain Relevance 0.24
Total nuclear HDAC activity (expressed as micromolar values of the deacetylated HDAC substrate standard per 6 ?
Positive_regulation (deacetylated) of HDAC
6) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.62 Pain Relevance 0.31
Nuclear HDAC activity was significantly higher in RA than in OA and normal controls and correlated with the amount of cytoplasmic TNF?.
Positive_regulation (higher) of HDAC associated with rheumatoid arthritis and osteoarthritis
7) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945023 Disease Relevance 1.62 Pain Relevance 0.65
significantly increased nuclear HDAC activity in RASFs (n = 3) and peaked at 6 h (P = 0.0001 vs 0 and 24 h) (Figure 5a), indicating that TNF?
Positive_regulation (increased) of HDAC
8) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.76 Pain Relevance 0.38
Arginine butyrate is a histone deacetylase (HDAC) inhibitor that also has been shown to increase IL2R-beta (CD122) subunit gene and protein expression.37 While low dose arginine butyrate showed no growth inhibitor effect of its own, combination studies with denileukin diftitox in vitro showed an increase in cytotoxicity.
Positive_regulation (increase) of HDAC in IL2R
9) Confidence 0.17 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.60 Pain Relevance 0.06
Among 2,500 human genes regulated similarly by both agonists, there were clear associations between PAR2 activation and cellular metabolism (1,000 genes), the cell cycle, the MAPK pathway, HDAC and sirtuin enzymes, inflammatory cytokines, and anti-complement function.
Positive_regulation (activation) of HDAC associated with inflammation, agonist and cytokine
10) Confidence 0.17 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2970545 Disease Relevance 0.70 Pain Relevance 0.35
Increased HDAC activity leads to hypoacetylation of target proteins, e.g., histones in the promoter area of tumor suppressor genes, thus resulting in transcriptional repression (Santos-Rosa and Caldas 2005).
Positive_regulation (Increased) of HDAC associated with cancer and repression
11) Confidence 0.16 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 1.03 Pain Relevance 0
HDAC activity results in a decrease in histone acetylation and a subsequent decrease in transcriptional activity, whereas HAT activity leads to an increase in histone acetylation and a subsequent increase in transcriptional activity [13].
Positive_regulation (results) of HDAC
12) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.20 Pain Relevance 0.10
Wang et al., (2008) demonstrated increased HDAC levels in the CD34-positive cell fractions of patients with PMF [30].
Positive_regulation (increased) of HDAC associated with myelofibrosis
13) Confidence 0.10 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 1.26 Pain Relevance 0.08
Recent evidence has suggested an important role for HDAC activity in COPD.
Positive_regulation (role) of HDAC associated with pulmonary disease
14) Confidence 0.10 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629979 Disease Relevance 0.92 Pain Relevance 0.11
Therapeutic strategies to increase HDAC activity may, therefore, be expected to reduce inflammation and restore steroid responsiveness.
Positive_regulation (increase) of HDAC associated with inflammation
15) Confidence 0.08 Published 2005 Journal Expert Opin. Ther. Targets Section Abstract Doc Link 16300464 Disease Relevance 1.00 Pain Relevance 0.57
Thus, accumulation of pyruvate in cancer cells is not conducive to cell proliferation because of the ability of this metabolite to induce apoptosis via HDAC inhibition.
Positive_regulation (induce) of HDAC associated with cancer and apoptosis
16) Confidence 0.07 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 1.17 Pain Relevance 0.03
The latter mechanism may be very useful to restore HDAC activity impaired by oxidative stress, thus resensitizing COPD patients to the anti-inflammatory effects of corticosteroids.
Positive_regulation (restore) of HDAC associated with stress, corticosteroid, pulmonary disease and inflammation
17) Confidence 0.06 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.93 Pain Relevance 0.47

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