INT97695

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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.44
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
DRG 1
dentin 1
Dh (Mus musculus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 50 100.00 Very High Very High Very High
Dorsal horn 8 100.00 Very High Very High Very High
Pain 9 98.52 Very High Very High Very High
Sciatic nerve 14 89.52 High High
Spinal cord 28 80.76 Quite High
long-term potentiation 84 78.88 Quite High
ectopic activity 3 77.84 Quite High
Glutamate 2 72.48 Quite High
Neuropathic pain 3 70.20 Quite High
Inflammation 6 68.56 Quite High
Disease Link Frequency Relevance Heat
Dentin Sensitivity 7 100.00 Very High Very High Very High
Tooth Loss 1 94.04 High High
Stress 1 92.40 High High
Paralysis 1 86.36 High High
Injury 4 81.48 Quite High
Neuropathic Pain 8 81.20 Quite High
INFLAMMATION 3 68.56 Quite High
Pain 8 49.36 Quite Low
Nervous System Injury 2 46.96 Quite Low
Hyperalgesia 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only cPGI(2) significantly increased the DRG and DH activity in a dose-dependent manner, with ED(50) values of 0.05 (0.01-0.96) and 0.69 (0.11-1.04) mg/kg, respectively.
Positive_regulation (increased) of DH in DRG associated with dorsal horn
1) Confidence 0.33 Published 2001 Journal Brain Res. Section Abstract Doc Link 11516414 Disease Relevance 0.59 Pain Relevance 0.49
Effectiveness and safety of tisuacryl in treating dentin hypersensitivity (DH).
Positive_regulation (treating) of DH in dentin associated with dentin sensitivity
2) Confidence 0.33 Published 2010 Journal MEDICC Rev Section Title Doc Link 20387331 Disease Relevance 0.85 Pain Relevance 0.10
Our results also showed obvious differences in the HFS-induced c-Fos expression in mice and rats, 1) the peak expression of c-Fos in the mouse DH was detected at 3 h, whereas it was markedly increased in the DH of rats at 2 h [40]; and 2) the Fos-immunoreactive neurons were seen distributed across all of the mouse DH, while it distributed mainly in the superficial layers of rats DH [40] (and the present analysis, data not shown).


Positive_regulation (increased) of DH in neurons associated with spinal dorsal horn
3) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.51

General Comments

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