INT97701

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Context Info
Confidence 0.82
First Reported 2001
Last Reported 2011
Negated 1
Speculated 5
Reported most in Body
Documents 191
Total Number 196
Disease Relevance 115.33
Pain Relevance 100.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
spinal cord 16
spinal 14
neurons 13
microglia 12
dorsal root ganglion 6
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 367 99.92 Very High Very High Very High
Spinal nerve ligature 73 99.92 Very High Very High Very High
Brush evoked pain 125 99.90 Very High Very High Very High
Pain 679 99.88 Very High Very High Very High
allodynia 555 99.84 Very High Very High Very High
dorsal root ganglion 428 99.84 Very High Very High Very High
noradrenaline 44 99.82 Very High Very High Very High
Opioid 42 99.80 Very High Very High Very High
Dorsal column 8 99.76 Very High Very High Very High
Perioperative pain 389 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 254 100.00 Very High Very High Very High
Neuropathic Pain 1380 99.90 Very High Very High Very High
Diabetes Mellitus 712 99.84 Very High Very High Very High
Ganglion Cysts 491 99.84 Very High Very High Very High
Post Operative Pain 407 99.74 Very High Very High Very High
Injury 621 99.70 Very High Very High Very High
Hyperalgesia 382 99.68 Very High Very High Very High
Experimental Arthritis 270 99.68 Very High Very High Very High
Pain 958 99.62 Very High Very High Very High
INFLAMMATION 1824 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylated p38 was only colocalized with the microglial surface marker OX-42, indicating a microglial localization of phosphorylated p38 in the SNI model.
Phosphorylation (phosphorylated) of p38
1) Confidence 0.82 Published 2007 Journal Anesthesiology Section Body Doc Link 17667577 Disease Relevance 0.06 Pain Relevance 0
The p38 activation was examined by p38 phosphorylation using a phosphorylated p38 antibody, and neuropathic pain-related behavior was evaluated before and after intrathecal infusion of a p38 inhibitor.
Spec (examined) Phosphorylation (phosphorylation) of p38
2) Confidence 0.82 Published 2007 Journal Anesthesiology Section Body Doc Link 17667577 Disease Relevance 0.08 Pain Relevance 0
Phosphorylated p38 was only colocalized with the microglial surface marker OX-42, indicating a microglial localization of phosphorylated p38 in the SNI model.
Phosphorylation (Phosphorylated) of p38
3) Confidence 0.82 Published 2007 Journal Anesthesiology Section Body Doc Link 17667577 Disease Relevance 0.07 Pain Relevance 0
The p38 activation was examined by p38 phosphorylation using a phosphorylated p38 antibody, and neuropathic pain-related behavior was evaluated before and after intrathecal infusion of a p38 inhibitor.
Spec (examined) Phosphorylation (phosphorylation) of p38
4) Confidence 0.82 Published 2007 Journal Anesthesiology Section Body Doc Link 17667577 Disease Relevance 0.08 Pain Relevance 0
Glial phosphorylated p38 MAP kinase mediates pain in a rat model of lumbar disc herniation and induces motor dysfunction in a rat model of lumbar spinal canal stenosis.
Phosphorylation (phosphorylated) of p38 in spinal associated with pain and pathologic constriction
5) Confidence 0.82 Published 2007 Journal Spine Section Title Doc Link 17224809 Disease Relevance 0.19 Pain Relevance 0.49
Both intraplantar formalin and intrathecal substance P produced an increase in spinal p38 phosphorylation and this phosphorylation (activation) was prevented when spinal p38beta, but not p38alpha, was down-regulated.
Phosphorylation (phosphorylation) of p38 in spinal associated with substance p and intrathecal
6) Confidence 0.82 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748168 Disease Relevance 0.39 Pain Relevance 0.73
The aim of the present study was to investigate whether phosphorylation of p38 (p-p38) also mediates mechanical allodynia and thermal hyperalgesia induced by plantar incision.
Spec (whether) Phosphorylation (phosphorylation) of p38 associated with allodynia and thermal hyperalgesia
7) Confidence 0.82 Published 2009 Journal Anesthesiology Section Abstract Doc Link 19104183 Disease Relevance 0.56 Pain Relevance 0.37
The aim of the present study was to investigate whether phosphorylation of p38 (p-p38) also mediates mechanical allodynia and thermal hyperalgesia induced by plantar incision.
Spec (whether) Phosphorylation (phosphorylation) of p38 associated with allodynia and thermal hyperalgesia
8) Confidence 0.82 Published 2009 Journal Anesthesiology Section Abstract Doc Link 19104183 Disease Relevance 0.56 Pain Relevance 0.37
We assessed mechanical allodynia, hypoalgesia, and motor function using von Frey hairs, treadmill tests, and immunohistochemical localization of phosphorylated p38 (P-p38) in the cauda equina, dorsal root ganglion (DRG), and spinal cord, which were also double-stained with NeuN (neuronal marker), GFAP (astrocyte/Schwann cell marker), or isolectin B4 (IB4; microglia marker).
Phosphorylation (phosphorylated) of p38 in dorsal root ganglion
9) Confidence 0.81 Published 2007 Journal Spine Section Body Doc Link 17224809 Disease Relevance 0 Pain Relevance 0
SUMMARY OF BACKGROUND DATA: In pathologic lumbar disc herniation-induced neuropathic pain and compression of cauda equina-induced motor dysfunction and hypoalgesia caused by SCS, glia are activated and produce certain cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukins, which play a crucial role in the pathogenesis of nerve degeneration. p38 is phosphorylated by these cytokines, suggesting that it may play an important role in pain transmission and nerve degeneration.
Phosphorylation (phosphorylated) of p38 in nerve
10) Confidence 0.81 Published 2007 Journal Spine Section Body Doc Link 17224809 Disease Relevance 0.07 Pain Relevance 0
We assessed mechanical allodynia, hypoalgesia, and motor function using von Frey hairs, treadmill tests, and immunohistochemical localization of phosphorylated p38 (P-p38) in the cauda equina, dorsal root ganglion (DRG), and spinal cord, which were also double-stained with NeuN (neuronal marker), GFAP (astrocyte/Schwann cell marker), or isolectin B4 (IB4; microglia marker).
Phosphorylation (phosphorylated) of p38 in dorsal root ganglion
11) Confidence 0.81 Published 2007 Journal Spine Section Body Doc Link 17224809 Disease Relevance 0 Pain Relevance 0
An increase in phosphorylation (activation) of p38 (P-p38) was observed in the dorsal spinal cord after carrageenan paw injection, assessed by both Western blotting and immunohistochemistry.
Phosphorylation (phosphorylation) of p38 in paw associated with spinal cord
12) Confidence 0.81 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16307586 Disease Relevance 0.76 Pain Relevance 1.02
An increase in phosphorylation (activation) of p38 (P-p38) was observed in the dorsal spinal cord after carrageenan paw injection, assessed by both Western blotting and immunohistochemistry.
Phosphorylation (phosphorylation) of p38 in paw associated with spinal cord
13) Confidence 0.81 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16307586 Disease Relevance 0.81 Pain Relevance 1.05
Fifteen hours later, tumor necrosis factor alpha, interleukin 1beta, p38 MAPK, and phosphorylated p38 MAPK were measured by enzyme-linked immunosorbent assay in DRGs and in the spinal cord.
Phosphorylation (phosphorylated) of p38 in spinal cord
14) Confidence 0.80 Published 2006 Journal Anesthesiology Section Body Doc Link 16810005 Disease Relevance 0 Pain Relevance 0
In conclusion, we postulate that the phosphorylation of p38 MAPK is involved in the elimination of infiltrating inflammatory cells during the course of EAN and may possibly modulate recovery in autoimmune disorders of the peripheral nervous system.
Phosphorylation (phosphorylation) of p38 in peripheral nervous system associated with autoimmune disease, peripheral nervous system, inflammation and neuritis
15) Confidence 0.80 Published 2005 Journal Brain Res. Section Abstract Doc Link 15804444 Disease Relevance 1.03 Pain Relevance 0.98
Western blot analysis showed that phosphorylated p38 (p-p38) MAPK protein was significantly increased in the sciatic nerves of rats in the early and peak phases of EAN, and declined gradually thereafter.
Phosphorylation (phosphorylated) of p38 in sciatic nerves associated with sciatic nerve and neuritis
16) Confidence 0.80 Published 2005 Journal Brain Res. Section Abstract Doc Link 15804444 Disease Relevance 0.73 Pain Relevance 0.77
Expression of the p55 TNF soluble receptor (sTNFRs) by HSV-mediated gene transfer resulted in reduced pain behavior and a decreased number of ED1-positive cells, as well as decreased phosphorylation of the p38 MAP kinase (p-p38) and diminished expression of mTNF-alpha in the dorsal horn.
Phosphorylation (phosphorylation) of p38 in dorsal horn
17) Confidence 0.80 Published 2006 Journal Ann. Neurol. Section Body Doc Link 16634039 Disease Relevance 0.13 Pain Relevance 0
Expression of the p55 TNF soluble receptor (sTNFRs) by HSV-mediated gene transfer resulted in reduced pain behavior and a decreased number of ED1-positive cells, as well as decreased phosphorylation of the p38 MAP kinase (p-p38) and diminished expression of mTNF-alpha in the dorsal horn.
Phosphorylation (phosphorylation) of p38 in dorsal horn
18) Confidence 0.80 Published 2006 Journal Ann. Neurol. Section Body Doc Link 16634039 Disease Relevance 0.13 Pain Relevance 0
None of the other cytoplasmic loops and termini of the channel are phosphorylated by activated p38alpha in these assays.
Phosphorylation (phosphorylated) of p38
19) Confidence 0.79 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16014723 Disease Relevance 0.22 Pain Relevance 1.03
We show in this study that sodium channels and p38 MAP kinase colocalize in rat brain tissue and that activated p38alpha phosphorylates L1 of Nav1.6, specifically at serine 553 (S553), in vitro.
Phosphorylation (phosphorylates) of p38 in brain associated with sodium channel and nav1.6
20) Confidence 0.79 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16014723 Disease Relevance 0.24 Pain Relevance 1.02

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