INT97702

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 69
Total Number 70
Disease Relevance 49.21
Pain Relevance 36.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
spinal cord 14
spinal 14
microglia 8
paw 8
nerve 6
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 377 100.00 Very High Very High Very High
Spinal cord 291 100.00 Very High Very High Very High
noradrenaline 33 99.82 Very High Very High Very High
Opioid 28 99.80 Very High Very High Very High
substance P 11 99.74 Very High Very High Very High
Eae 120 99.72 Very High Very High Very High
cytokine 134 99.68 Very High Very High Very High
agonist 108 99.68 Very High Very High Very High
Sciatic nerve 57 99.68 Very High Very High Very High
Glutamate receptor 19 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 383 100.00 Very High Very High Very High
Nervous System Injury 266 99.98 Very High Very High Very High
Stress 113 99.96 Very High Very High Very High
Diabetes Mellitus 472 99.84 Very High Very High Very High
Enteritis 17 99.68 Very High Very High Very High
Injury 126 99.66 Very High Very High Very High
Neuropathic Pain 452 99.50 Very High Very High Very High
Cancer 40 99.48 Very High Very High Very High
Myocardial Infarction 632 99.44 Very High Very High Very High
INFLAMMATION 533 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both intraplantar formalin and intrathecal substance P produced an increase in spinal p38 phosphorylation and this phosphorylation (activation) was prevented when spinal p38beta, but not p38alpha, was down-regulated.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p38 in spinal associated with substance p and intrathecal
1) Confidence 0.69 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15748168 Disease Relevance 0.40 Pain Relevance 0.73
An increase in phosphorylation (activation) of p38 (P-p38) was observed in the dorsal spinal cord after carrageenan paw injection, assessed by both Western blotting and immunohistochemistry.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of p38 in paw associated with spinal cord
2) Confidence 0.69 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16307586 Disease Relevance 0.81 Pain Relevance 1.05
An increase in phosphorylation (activation) of p38 (P-p38) was observed in the dorsal spinal cord after carrageenan paw injection, assessed by both Western blotting and immunohistochemistry.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p38 in paw associated with spinal cord
3) Confidence 0.69 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16307586 Disease Relevance 0.81 Pain Relevance 1.05
The increase in phosphorylated p38 was detected in laminae I-IV of the dorsal horn.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of p38 in dorsal horn associated with dorsal horn
4) Confidence 0.66 Published 2005 Journal Neuropeptides Section Abstract Doc Link 16176831 Disease Relevance 0.17 Pain Relevance 0.68
Because glutamate receptor stimulation can increase spinal p38 phosphorylation [28], it is also possible that p38 links the previously described anti-inflammatory glutamate receptor mechanisms to the present study.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p38 in spinal associated with inflammation and glutamate receptor
5) Confidence 0.66 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.66 Pain Relevance 0.53
could either be the result of p38 phosphorylation or the cause of p38 activation in neurons and microglia in inflammation.
Positive_regulation (cause) of Phosphorylation (phosphorylation) of p38 in microglia associated with inflammation
6) Confidence 0.66 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 1.00 Pain Relevance 1.11
Furthermore, preincubation with either actinomycin D or cyclohexamide, general inhibitors of transcription or protein synthesis, respectively, almost completely blocked the inhibitory action of NA on the ATP-stimulated phosphorylation of p38.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of p38 associated with noradrenaline
7) Confidence 0.60 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19524113 Disease Relevance 0.18 Pain Relevance 0.42
An increase in phosphorylation (activation) of p38 (P-p38) was observed in the dorsal spinal cord after carrageenan paw injection, assessed by both Western blotting and immunohistochemistry.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p38 in paw associated with spinal cord
8) Confidence 0.50 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16307586 Disease Relevance 0.76 Pain Relevance 1.03
An increase in phosphorylation (activation) of p38 (P-p38) was observed in the dorsal spinal cord after carrageenan paw injection, assessed by both Western blotting and immunohistochemistry.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of p38 in paw associated with spinal cord
9) Confidence 0.50 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16307586 Disease Relevance 0.76 Pain Relevance 1.02
In the present study we showed an increase in the phosphorylation of the p38 MAPK in the diabetic post-infarct GK rat myocardium.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p38 in myocardium associated with diabetes mellitus
10) Confidence 0.49 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.44 Pain Relevance 0.07
Increased p38 MAP kinase phosphorylation in diabetic GK rats after MI
Positive_regulation (Increased) of Phosphorylation (phosphorylation) of p38 MAP kinase associated with diabetes mellitus and myocardial infarction
11) Confidence 0.49 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.34 Pain Relevance 0
We showed here that in the diabetic heart a higher level of cardiac collagen deposition was associated with an increase in p38 phosphorylation in myocardial tissue 12 weeks after MI.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p38 in heart associated with diabetes mellitus and myocardial infarction
12) Confidence 0.49 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.37 Pain Relevance 0.16
While Akt kinase activation could not explain this effect, the increase in p38 MAP kinase phosphorylation might have played a role.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p38 MAP kinase
13) Confidence 0.49 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.26 Pain Relevance 0.17
Western blot analysis showed that phosphorylated p38 (p-p38) MAPK protein was significantly increased in the sciatic nerves of rats in the early and peak phases of EAN, and declined gradually thereafter.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of p38 in sciatic nerves associated with sciatic nerve and neuritis
14) Confidence 0.49 Published 2005 Journal Brain Res. Section Abstract Doc Link 15804444 Disease Relevance 0.75 Pain Relevance 0.82
None of the other cytoplasmic loops and termini of the channel are phosphorylated by activated p38alpha in these assays.
Positive_regulation (activated) of Phosphorylation (phosphorylated) of p38
15) Confidence 0.49 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16014723 Disease Relevance 0.22 Pain Relevance 1.03
In the present work, we show that intrathecal delivery of an N-truncated fragment of dynorphin A, dynorphin A 2-17 (dyn2-17), which has no activity at opioid receptors, induced a 8-10-fold increase in phosphorylation of p38 in the spinal cord.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p38 in spinal cord associated with dynorphin, opioid receptor, spinal cord and intrathecal
16) Confidence 0.48 Published 2005 Journal Neuropeptides Section Abstract Doc Link 16176831 Disease Relevance 0.17 Pain Relevance 0.66
To elucidate the involvement of the noradrenergic system in the regulation of spinal microglial activity, we examined the effects of noradrenaline (NA) on the phosphorylation of three MAP kinases (extracellular signal-regulated kinase (ERK), p38, or c-Jun N-terminal kinase (JNK)) stimulated by ATP in rat cultured spinal microglia using Western blotting.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of p38 in spinal associated with noradrenaline
17) Confidence 0.44 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19524113 Disease Relevance 0 Pain Relevance 0.27
We have demonstrated that tactile allodynia and spontaneous pain of female rats with tibia tumors were correlated with the increase of both phosphorylated-p38MAPK (p-p38MAPK) and proinflammatory cytokines (IL-1beta and TNF-alpha) in the spinal cord 6 days after Walker 256 cells' inoculation.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of p-p38MAPK in spinal cord associated with pain, brush evoked pain, cancer, spontaneous pain, spinal cord and cytokine
18) Confidence 0.41 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.08 Pain Relevance 0.92
We found that prolonged knockdown of TLR4 during the 3-day administration of TLR4 small interfering RNA (siRNA; 2 microg/rat/day, i.t.) could attenuate hyperalgesia developed by Walker 256 cells' inoculation and decrease the phosphorylation of p38 as well as the increase of IL-1beta and TNF-alpha expression.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of p38 associated with hyperalgesia
19) Confidence 0.41 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.07 Pain Relevance 1.02
Noradrenaline reduces the ATP-stimulated phosphorylation of p38 MAP kinase via beta-adrenergic receptors-cAMP-protein kinase A-dependent mechanism in cultured rat spinal microglia.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of p38 in spinal associated with noradrenaline
20) Confidence 0.40 Published 2009 Journal Neurochem. Int. Section Title Doc Link 19524113 Disease Relevance 0 Pain Relevance 0.55

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