INT97704

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Context Info
Confidence 0.13
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.54
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX2) oxidoreductase activity (HMOX2) endoplasmic reticulum (HMOX2)
plasma membrane (HMOX2) transmembrane transport (HMOX2)
HMOX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 15 97.52 Very High Very High Very High
Hyperalgesia 8 95.68 Very High Very High Very High
intrathecal 1 92.16 High High
endometriosis 7 92.12 High High
Pain 2 79.64 Quite High
bradykinin 8 78.56 Quite High
agonist 2 76.56 Quite High
Inflammatory response 1 60.56 Quite High
COX2 2 25.00 Low Low
cytokine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Endometriosis 9 98.56 Very High Very High Very High
INFLAMMATION 12 97.52 Very High Very High Very High
Hyperalgesia 8 95.68 Very High Very High Very High
Disease 3 93.20 High High
Stress 4 83.88 Quite High
Pressure And Volume Under Development 1 80.44 Quite High
Fever 1 79.92 Quite High
Pain 2 79.64 Quite High
Cancer 1 78.72 Quite High
Disease Progression 1 51.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endometriotic lesions demonstrate increased aromatase expression in association with increased cyclo-oxygenase-2 expression, especially in red lesions which represent earlier stages of inflammation.
Positive_regulation (increased) of Gene_expression (expression) of cyclo-oxygenase-2 associated with endometriosis and inflammation
1) Confidence 0.13 Published 2009 Journal Minerva Ginecol Section Abstract Doc Link 19745796 Disease Relevance 1.07 Pain Relevance 0.33
Ellagic acid suppressed the lipopolysaccharide-induced increase in protein expression of cyclo-oxygenase-2 (COX-2), microsomal PGE synthase-1 (mPGEs-1) and cytosolic phospholipase A2alpha (cPLA2alpha), while it had no effect on the constitutively expressed COX-1 protein.
Positive_regulation (increase) of Gene_expression (expression) of cyclo-oxygenase-2
2) Confidence 0.10 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.58 Pain Relevance 0.21
SB203580 did not, however, affect the increased levels of interleukin-1beta and cyclo-oxygenase 2 protein observed in the hindpaw following complete Freund's adjuvant injection.
Neg (not) Positive_regulation (increased) of Gene_expression (levels) of cyclo-oxygenase 2 protein
3) Confidence 0.01 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11516436 Disease Relevance 0.89 Pain Relevance 0.83

General Comments

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