INT97707

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Context Info
Confidence 0.18
First Reported 1998
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.96
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX2) oxidoreductase activity (HMOX2) endoplasmic reticulum (HMOX2)
plasma membrane (HMOX2) transmembrane transport (HMOX2)
Anatomy Link Frequency
macrophage 1
HMOX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 36 100.00 Very High Very High Very High
cINOD 5 99.24 Very High Very High Very High
Inflammation 38 97.04 Very High Very High Very High
Hyperalgesia 8 96.12 Very High Very High Very High
Osteoarthritis 3 96.00 Very High Very High Very High
substance P 10 94.84 High High
intrathecal 1 92.60 High High
rheumatoid arthritis 5 91.08 High High
bradykinin 8 78.56 Quite High
agonist 2 76.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 36 97.04 Very High Very High Very High
Injury 5 96.84 Very High Very High Very High
Hyperalgesia 8 96.12 Very High Very High Very High
Osteoarthritis 3 96.00 Very High Very High Very High
Rheumatoid Arthritis 5 91.08 High High
Diabetes Mellitus 45 90.76 High High
Stress 10 84.32 Quite High
Gastric Motility Disorder 27 78.32 Quite High
Enteropathy 1 58.32 Quite High
Death 3 49.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this context, our study is also the first to report changes in HO-2, the constitutive form of heme oxygenase that is largely responsible for production of carbon monoxide, another endogenous gaseous neuromodulator of considerable importance in the inhibitory control of gastrointestinal motility [3,21-25].
Regulation (changes) of HO-2
1) Confidence 0.18 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.65 Pain Relevance 0.15
The safety of the cyclo-oxygenase-2 (COX-2) selective NSAID, nimesulide, has been evaluated from information (a) in clinical trials in osteoarthritis that have been performed in Europe as well as in earlier pilot studies that were performed in patients with rheumatoid arthritis in the USA, and (b) in post-marketing studies (PMS) that have been performed by the manufacturer since the introduction of the drug in Europe and some South American countries.
Regulation (safety) of cyclo-oxygenase-2 associated with rheumatoid arthritis, cinod and osteoarthritis
2) Confidence 0.16 Published 1998 Journal Inflammopharmacology Section Abstract Doc Link 17657620 Disease Relevance 0.32 Pain Relevance 0.29
SB203580 did not, however, affect the increased levels of interleukin-1beta and cyclo-oxygenase 2 protein observed in the hindpaw following complete Freund's adjuvant injection.
Neg (not) Regulation (affect) of cyclo-oxygenase 2 protein
3) Confidence 0.02 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11516436 Disease Relevance 0.89 Pain Relevance 0.83
The p38 MAPK pathway has been shown to affect the mRNA stability of proinflammatory genes, mainly that of mRNA for cytokines such as IL-2, IL-3, IL-6, IL-8, TNF, and GM-CSF [90-92] but also that of mRNA for cyclo-oxygenase 2 (COX-2) [93], vascular endothelial growth factor (VEGF) [94], macrophage inflammatory protein 2 (MIP-2) [91], urokinase-type plasminogen activator (uPAR) [95], and MKK6 [96].
Regulation (affect) of cyclo-oxygenase 2 in macrophage associated with inflammation and cytokine
4) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.10 Pain Relevance 0.21

General Comments

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