INT97710

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Context Info
Confidence 0.79
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 8
Disease Relevance 7.18
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
astrocyte 2
nerve 1
brain 1
Apoe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 56 99.76 Very High Very High Very High
Nerve growth factor 8 99.66 Very High Very High Very High
Clonidine 8 98.94 Very High Very High Very High
Kinase C 24 98.84 Very High Very High Very High
Serotonin 8 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 104 100.00 Very High Very High Very High
Disease 32 99.34 Very High Very High Very High
Pathologic Processes 8 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the protein kinase C activator phorbol 12-myristate 13-acetate decreased both apolipoprotein E secretion (to 59% at 48 h) and mRNA expression (to 22% at 1 h).
Localization (secretion) of apolipoprotein E associated with kinase c and disorder of lipid metabolism
1) Confidence 0.79 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 1.04 Pain Relevance 0.36
Isoproterenol (50 nM, a beta-adrenoceptor agonist) enhanced, while clonidine (250 nM, an alpha2-adrenoceptor agonist) decreased, secreted apolipoprotein E.
Localization (secreted) of apolipoprotein E associated with agonist, disorder of lipid metabolism and clonidine
2) Confidence 0.79 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 1.04 Pain Relevance 0.57
We also show that phorbol 12-myristate 13-acetate and dibutyryl-cAMP have opposite effects on nerve growth factor, as compared to apolipoprotein E, secretion, suggesting that the results obtained were unlikely to be due to a general effect on protein synthesis.
Localization (secretion) of apolipoprotein E in nerve associated with nerve growth factor and disorder of lipid metabolism
3) Confidence 0.79 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 0.61 Pain Relevance 0.54
Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures.
Localization (secretion) of apolipoprotein E in astrocyte associated with disorder of lipid metabolism
4) Confidence 0.79 Published 2001 Journal Neuroscience Section Title Doc Link 11516830 Disease Relevance 1.00 Pain Relevance 0.14
We show here that in rat primary hippocampal astrocyte cultures, dibutyryl-cAMP increased apolipoprotein E secretion with time in a dose-dependent manner (to 177% at 48 h) and that retinoic acid potentiated this effect (to 298% at 48 h).
Localization (secretion) of apolipoprotein E in astrocyte associated with disorder of lipid metabolism
5) Confidence 0.79 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 1.02 Pain Relevance 0.07
Apolipoprotein E secretion was also modulated by receptor agonists for the adenylyl cyclase/cAMP pathway.
Localization (secretion) of Apolipoprotein E associated with agonist and disorder of lipid metabolism
6) Confidence 0.79 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 1.06 Pain Relevance 0.48
Arterenol (1 microM, an alpha1-adrenoceptor agonist) and serotonin (2.5 microM) enhanced, whereas carbachol (10 microM, an acetylcholine muscarinic receptor agonist) decreased secreted apolipoprotein E.
Localization (secreted) of apolipoprotein E associated with agonist, serotonin and disorder of lipid metabolism
7) Confidence 0.79 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 0.79 Pain Relevance 0.60
Alterations in these signalling pathways in Alzheimer's disease brain may have consequences for apolipoprotein E secretion in this disorder.
Localization (secretion) of apolipoprotein E in brain associated with disease and disorder of lipid metabolism
8) Confidence 0.79 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 0.63 Pain Relevance 0.43

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