INT97713

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 4.57
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
cerebral spinal fluid 1
astrocyte 1
Apoe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 14 99.96 Very High Very High Very High
Multiple sclerosis 48 99.20 Very High Very High Very High
Clonidine 2 99.16 Very High Very High Very High
Serotonin 2 98.00 Very High Very High Very High
aspirin 4 95.92 Very High Very High Very High
Kinase C 6 94.64 High High
cINOD 7 87.32 High High
Inflammation 9 79.52 Quite High
cytokine 8 78.48 Quite High
Nerve growth factor 2 77.28 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 37 100.00 Very High Very High Very High
Demyelinating Disease 59 99.20 Very High Very High Very High
Syndrome 14 96.80 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 2 88.48 High High
Multiple Sclerosis 2 86.84 High High
Disease 24 80.96 Quite High
INFLAMMATION 12 79.52 Quite High
Autoimmune Disease 8 74.00 Quite High
Rheumatoid Arthritis 17 71.76 Quite High
Systemic Lupus Erythematosus 19 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, astrocyte and mixed glial apoE protein levels were significantly reduced following exposure to COX-2-specific indomethacin amides and an inactive indomethacin derivative.
Negative_regulation (reduced) of apoE in astrocyte
1) Confidence 0.59 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511323 Disease Relevance 0.61 Pain Relevance 0.68
Arterenol (1 microM, an alpha1-adrenoceptor agonist) and serotonin (2.5 microM) enhanced, whereas carbachol (10 microM, an acetylcholine muscarinic receptor agonist) decreased secreted apolipoprotein E.
Negative_regulation (decreased) of apolipoprotein E associated with agonist, serotonin and disorder of lipid metabolism
2) Confidence 0.58 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 0.79 Pain Relevance 0.60
Isoproterenol (50 nM, a beta-adrenoceptor agonist) enhanced, while clonidine (250 nM, an alpha2-adrenoceptor agonist) decreased, secreted apolipoprotein E.
Negative_regulation (decreased) of apolipoprotein E associated with agonist, disorder of lipid metabolism and clonidine
3) Confidence 0.43 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 1.05 Pain Relevance 0.57
Recently, Gaillard et al conformed that the decreasing CSF (cerebral spinal fluid) apo E (apolipoprotein E) concentrations in MS patients as apoE was postulated to be a major lipid carrier protein [23], therefore, we wonder if the CSF apoA-I concentrations would be increased in MS patients, our next task is to conform the hypothesis.
Negative_regulation (decreasing) of apolipoprotein E in cerebral spinal fluid associated with multiple sclerosis and disorder of lipid metabolism
4) Confidence 0.26 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2860353 Disease Relevance 2.12 Pain Relevance 0.66

General Comments

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