INT97714

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.83
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Apoe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 14 99.96 Very High Very High Very High
Kinase C 6 99.14 Very High Very High Very High
Serotonin 2 98.00 Very High Very High Very High
Clonidine 2 86.52 High High
Nerve growth factor 2 77.28 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 26 100.00 Very High Very High Very High
Disease 8 82.76 Quite High
Pathologic Processes 2 70.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Arterenol (1 microM, an alpha1-adrenoceptor agonist) and serotonin (2.5 microM) enhanced, whereas carbachol (10 microM, an acetylcholine muscarinic receptor agonist) decreased secreted apolipoprotein E.
Negative_regulation (decreased) of Localization (secreted) of apolipoprotein E associated with agonist, serotonin and disorder of lipid metabolism
1) Confidence 0.58 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 0.79 Pain Relevance 0.60
In contrast, the protein kinase C activator phorbol 12-myristate 13-acetate decreased both apolipoprotein E secretion (to 59% at 48 h) and mRNA expression (to 22% at 1 h).
Negative_regulation (decreased) of Localization (secretion) of apolipoprotein E associated with kinase c and disorder of lipid metabolism
2) Confidence 0.58 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 1.04 Pain Relevance 0.36

General Comments

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