INT97715

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.98
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
astrocyte 2
Apoe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 7 99.64 Very High Very High Very High
Kinase C 6 97.24 Very High Very High Very High
aspirin 4 95.52 Very High Very High Very High
Nerve growth factor 2 92.96 High High
agonist 14 83.00 Quite High
Serotonin 2 75.44 Quite High
Clonidine 2 65.96 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 28 100.00 Very High Very High Very High
Disease 14 98.76 Very High Very High Very High
Pathologic Processes 2 91.76 High High
INFLAMMATION 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The failure of NSAIDs to significantly alter apoE expression may have been indicative of a nontranscriptional mechanism of apoE protein induction.
Regulation (alter) of Gene_expression (expression) of apoE associated with cinod
1) Confidence 0.62 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511323 Disease Relevance 0.49 Pain Relevance 0.69
We conclude that astrocyte apolipoprotein E production can be regulated by factors that affect cAMP intracellular concentration or activate protein kinase C.
Regulation (regulated) of Gene_expression (production) of apolipoprotein E in astrocyte associated with kinase c and disorder of lipid metabolism
2) Confidence 0.61 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 0.53 Pain Relevance 0.51
Therefore, understanding the regulated synthesis of apolipoprotein E is important for determining its role in Alzheimer's disease.
Regulation (regulated) of Gene_expression (synthesis) of apolipoprotein E associated with disease and disorder of lipid metabolism
3) Confidence 0.27 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516830 Disease Relevance 0.96 Pain Relevance 0.03

General Comments

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