INT97737

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.64
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) mitochondrion (Mapk3) Golgi apparatus (Mapk3)
protein complex assembly (Mapk3) protein complex (Mapk3) cytoplasm (Mapk3)
Anatomy Link Frequency
eyes 2
neurons 2
brains 2
DRG 2
cortex 2
Mapk3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 9 99.80 Very High Very High Very High
Inflammation 77 98.00 Very High Very High Very High
spinal dorsal horn 2 97.88 Very High Very High Very High
opiate 7 97.68 Very High Very High Very High
Sciatic nerve 2 94.84 High High
Hyperalgesia 12 94.40 High High
Potency 1 94.00 High High
Morphine 2 93.44 High High
addiction 3 90.28 High High
cytokine 5 89.92 High High
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 37 99.98 Very High Very High Very High
Ganglion Cysts 14 99.80 Very High Very High Very High
Nervous System Injury 11 99.04 Very High Very High Very High
Hypoxia 6 99.04 Very High Very High Very High
Diabetes Mellitus 144 98.78 Very High Very High Very High
INFLAMMATION 84 98.00 Very High Very High Very High
Apoptosis 6 96.72 Very High Very High Very High
Urological Neuroanatomy 4 95.08 Very High Very High Very High
Diabetic Macular Edema 22 94.88 High High
Hyperalgesia 13 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a similar manner, phosphorylation of ERK1/2 was also decreased by these inhibitors.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of ERK1
1) Confidence 0.57 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11517280 Disease Relevance 0.66 Pain Relevance 0.92
Third, similar to our results, 2 hours of MCAO followed by reperfusion in the rat causes phosphorylation of ERK1/2 in both the ipsilateral and contralateral cortex after 6 hours of reperfusion [50].
Negative_regulation (followed) of Phosphorylation (phosphorylation) of ERK1 in cortex associated with middle cerebral artery infarction
2) Confidence 0.41 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2923122 Disease Relevance 0.74 Pain Relevance 0.03
Endostatin also interacts with VEGF signal transduction by reducing VEGF-induced kinase (Erk1/2) phosphorylation [25].
Negative_regulation (reducing) of Phosphorylation (phosphorylation) of Erk1
3) Confidence 0.41 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2397381 Disease Relevance 0.17 Pain Relevance 0.16
Notably, pronounced downregulations of phosphorylated MEK (85%) and ERK1/2 (pERK1: 81%; pERK2: 80%) were quantitated in brains of opiate addicts.
Negative_regulation (downregulations) of Phosphorylation (phosphorylated) of ERK1 in brains associated with opiate
4) Confidence 0.41 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15198681 Disease Relevance 0.47 Pain Relevance 0.87
In order to examine the spatial and temporal patterns of ERK1/2 phosphorylation and expression, all three groups of rats were anesthetized with intraperitoneal injection of sodium pentobarbital (50 mg/kg, i.p.) and decapitated at various time points (5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 6 h, 24 h, 48 h) after the injection.
Spec (examine) Negative_regulation (patterns) of Phosphorylation (phosphorylation) of ERK1
5) Confidence 0.38 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.30 Pain Relevance 0.37
Western blotting analysis of DRG extracts detected phosphorylation of ERK1 and ERK2 (extracellular signal-regulated kinases) that peaked 10 min after exposure to 17beta-estradiol.
Negative_regulation (detected) of Phosphorylation (phosphorylation) of ERK1 in DRG associated with dorsal root ganglion
6) Confidence 0.31 Published 2004 Journal Neuroscience Section Abstract Doc Link 15541884 Disease Relevance 0.82 Pain Relevance 0.31
Our results in STZ-induced diabetic rats suggest that angiostatin suppresses VEGF expression by inhibition of phosphorylation of the p42/p44 MAP kinase.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of p44 associated with diabetes mellitus
7) Confidence 0.22 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.72 Pain Relevance 0
In our study, retinal phosphorylation of p42/p44 MAP kinase decreased in eyes receiving rAAV-angiostatin at one day after induction of diabetes (Figure 8).
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of p44 in eyes associated with diabetes mellitus
8) Confidence 0.22 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.65 Pain Relevance 0
We found a small number of phosphorylated extracellular signal-regulated kinase (pERK)-labelled neurons in laminae I-II and III-IV of the spinal dorsal horn in the control rats after 0.1 mA stimulation.
Negative_regulation (number) of Phosphorylation (phosphorylated) of pERK in neurons associated with spinal dorsal horn
9) Confidence 0.11 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15009135 Disease Relevance 0.66 Pain Relevance 0.33
In polarized CaCo2 cells, application of PC either from the apical or basolateral site inhibited the phosphorylation and activation of the MAP kinases p38, ERK1 and ERK2.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of ERK1
10) Confidence 0.07 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.45 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox