INT97748

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 9.83
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCL2L1) mitochondrion (BCL2L1) growth (BCL2L1)
cytoskeleton (BCL2L1) nucleus (BCL2L1) intracellular (BCL2L1)
Anatomy Link Frequency
lymphocytes 1
BCL2L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 12 99.98 Very High Very High Very High
cINOD 11 96.40 Very High Very High Very High
Analgesic 1 96.28 Very High Very High Very High
opioid receptor 1 89.04 High High
narcan 1 86.92 High High
antagonist 18 86.52 High High
Opioid 6 86.08 High High
Inflammation 104 78.24 Quite High
MU agonist 1 74.52 Quite High
dexamethasone 1 74.40 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 375 100.00 Very High Very High Very High
Shock 3 99.66 Very High Very High Very High
Hepatocellular Cancer 6 98.80 Very High Very High Very High
Cancer 108 97.28 Very High Very High Very High
Colon Cancer 40 97.00 Very High Very High Very High
Toxicity 5 94.48 High High
Repression 2 93.00 High High
Adhesions 67 83.28 Quite High
Endometriosis (extended) 4 79.32 Quite High
INFLAMMATION 133 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both ASA and indomethacin reduced the protein levels of Bcl-2 and Bcl-xl, but upregulated those of Bax and Bcl-xs.
Positive_regulation (upregulated) of Bcl-xs
1) Confidence 0.67 Published 2004 Journal Cancer Sci. Section Abstract Doc Link 15546508 Disease Relevance 0.76 Pain Relevance 0.49
Western blot analysis of sensitive and resistant LDC clonal lines confirmed increases in cyclin D1, STAT6, Bcl-xL, and BAD, with decreased expression of caspase 1.
Positive_regulation (increases) of Bcl-xL
2) Confidence 0.50 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16005468 Disease Relevance 1.10 Pain Relevance 0.06
These processes were accompanied by caspase activation and downregulation of the antiapoptotic proteins Bcl-2 and Bcl-x(L).
Positive_regulation (activation) of Bcl-x
3) Confidence 0.49 Published 2010 Journal Invest New Drugs Section Abstract Doc Link 19139819 Disease Relevance 0.91 Pain Relevance 0.10
Additionally, U69593 increased the content of the anti-apoptotic members of the Bcl-2 family of proteins, the Bcl-2 and Bcl-x(L), whereas it had no significant effect on the apoptosis-promoting homologues Bax, Bcl-x(S) and Bak.
Positive_regulation (increased) of Bcl-x associated with apoptosis
4) Confidence 0.46 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11517294 Disease Relevance 0.92 Pain Relevance 0.64
Acetaminophen induces a caspase-dependent and Bcl-XL sensitive apoptosis in human hepatoma cells and lymphocytes.
Positive_regulation (induces) of Bcl-XL in lymphocytes associated with paracetamol, hepatocellular cancer and apoptosis
5) Confidence 0.39 Published 2002 Journal Pharmacol. Toxicol. Section Title Doc Link 12005112 Disease Relevance 0.59 Pain Relevance 0.73
13 patients, and Bcl-XL was increased in 18
Positive_regulation (increased) of Bcl-XL
6) Confidence 0.30 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.93 Pain Relevance 0
was confirmed by the increase of Bcl-2 or Bcl-XL, both
Positive_regulation (increase) of Bcl-XL
7) Confidence 0.20 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.89 Pain Relevance 0
Although the mechanism for activating the expression and function of Bcl-2, Bcl-XL and Bax is not fully understood, it is possible that the p53 molecule plays a role in this process [30].
Positive_regulation (activating) of Bcl-XL
8) Confidence 0.07 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2873331 Disease Relevance 1.04 Pain Relevance 0.11
Other mechanisms include activating p53, upregulating heat shock protein 70, and upregulating antiapoptotic proteins Bcl-2 and Bcl-XL.
Positive_regulation (upregulating) of Bcl-XL associated with shock
9) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.18 Pain Relevance 0
Another potential target gene is the anti-apoptotic molecule Bcl–XL, which was found to be upregulated in plakoglobin-deficient cells leading to reduced apoptosis and thus might also be repressed by plakoglobin (Dusek et al. 2007a).
Positive_regulation (upregulated) of Bcl-XL associated with apoptosis
10) Confidence 0.05 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.53 Pain Relevance 0
This conclusion was founded on the observed upregulation in transcripts for AKT1 and Bcl-XL, paired with decreased gene expression for DRAM.
Positive_regulation (upregulation) of Bcl-XL
11) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.60 Pain Relevance 0.13
In cultures containing only SY cells and B. burgdorferi, there were prominent increases in transcript for the cell survival and anti-apoptotic molecules protein kinase B (AKT1) and BCL2-like (Bcl-XL) genes, combined with a decrease in transcript for pro-apoptotic damage-regulated autophagy modulator (DRAM) (Table 6-left, Figure 4A).
Positive_regulation (increases) of Bcl-XL associated with apoptosis
12) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.35 Pain Relevance 0

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