INT97750

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 4.90
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (FAS) protein complex assembly (FAS) cytoplasm (FAS)
signal transducer activity (FAS) cytosol (FAS) signal transduction (FAS)
FAS (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 14 99.98 Very High Very High Very High
opioid receptor 1 96.28 Very High Very High Very High
narcan 1 94.16 High High
antagonist 1 93.76 High High
Opioid 6 93.32 High High
MU agonist 1 81.76 Quite High
agonist 2 81.20 Quite High
ischemia 6 55.12 Quite High
cytokine 2 36.96 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 162 98.40 Very High Very High Very High
Ataxia 2 97.72 Very High Very High Very High
Death 30 97.28 Very High Very High Very High
Necrosis 16 93.76 High High
Cancer 16 87.24 High High
Hypothermia 26 75.00 Quite High
Myocardial Stunning 4 65.36 Quite High
Cv Unclassified Under Development 10 63.80 Quite High
Renal Insufficiency 2 63.68 Quite High
Reperfusion Injury 6 54.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In parallel, semi-quantitative Western blot and flow cytometry analysis showed that U69593 caused a rapid but transient up-regulation of Fas protein, suggesting that its effect on apoptosis is mediated by activation of the Fas/FasL apoptotic pathway.
Positive_regulation (caused) of Positive_regulation (regulation) of Fas associated with apoptosis
1) Confidence 0.49 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11517294 Disease Relevance 0.89 Pain Relevance 0.67
CPS induced Fas/CD95 upregulation, but more importantly Fas/CD95 ligand independent, TRPV1-dependent death receptor clustering and triggering of both extrinsic and intrinsic mitochondrial-dependent pathways.
Positive_regulation (induced) of Positive_regulation (upregulation) of Fas associated with qutenza and death
2) Confidence 0.49 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19502594 Disease Relevance 1.00 Pain Relevance 0.55
CPS induced Fas/CD95 upregulation, but more importantly Fas/CD95 ligand independent, TRPV1-dependent death receptor clustering and triggering of both extrinsic and intrinsic mitochondrial-dependent pathways.
Positive_regulation (induced) of Positive_regulation (upregulation) of CD95 associated with qutenza and death
3) Confidence 0.49 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19502594 Disease Relevance 1.00 Pain Relevance 0.55
In the ModHT group, a prolonged aortic crossclamping time tended to induce a higher increase of Fas over time (r = 0.685, p = 0.061) (Figure 3).
Positive_regulation (induce) of Positive_regulation (increase) of Fas
4) Confidence 0.31 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1783850 Disease Relevance 1.08 Pain Relevance 0.03
In ModHT patients, a prolonged ischemic time tended to induce a higher increase of Fas (p = 0.061).


Positive_regulation (induce) of Positive_regulation (increase) of Fas
5) Confidence 0.31 Published 2007 Journal J Cardiothorac Surg Section Abstract Doc Link PMC1783850 Disease Relevance 0.94 Pain Relevance 0

General Comments

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