INT97763

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 60 97.92 Very High Very High Very High
Opioid 2 95.20 Very High Very High Very High
Serotonin 2 94.32 High High
gABA 3 87.84 High High
Potency 3 84.24 Quite High
agonist 28 75.80 Quite High
antidepressant 1 52.80 Quite High
depression 4 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 10 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Hyperglycemia 4 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 2 5.00 Very Low Very Low Very Low
Hypercalcemia 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Headache 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The acylphloroglucinole hyperforin failed to inhibit 125I-astressin binding to hCRF, receptor up to 10 microM.
Negative_regulation (inhibit) of CRF Binding (binding) of
1) Confidence 0.42 Published 2001 Journal Pharmacopsychiatry Section Abstract Doc Link 11518063 Disease Relevance 0 Pain Relevance 0.44
Nonpeptide binding does not affect CRF binding to the N-domain, but allosterically inhibits CRF binding to the J-domain.
Negative_regulation (inhibits) of CRF Binding (binding) of
2) Confidence 0.07 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656815 Disease Relevance 0 Pain Relevance 0.10
Binding of a radiolabeled amino-terminal-truncated peptide ([125I] astressin, a CRF(12-41) analogue) to the wild-type CRF1 receptor is not appreciably inhibited by nonpeptide ligands [37, 38, 64], and nonpeptide antagonists completely block CRF-stimulated activation of a J-domain fragment [38, 59].
Negative_regulation (inhibited) of CRF Binding (Binding) of associated with antagonist
3) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656815 Disease Relevance 0 Pain Relevance 0.21

General Comments

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