INT97768

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.49
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLG) extracellular space (PLG) extracellular region (PLG)
plasma membrane (PLG)
Anatomy Link Frequency
macrophages 2
cartilage 2
TMJ 2
PLG (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 47 100.00 Very High Very High Very High
Osteoarthritis 37 94.40 High High
Snapping jaw 4 91.64 High High
cytokine 17 90.48 High High
antagonist 3 77.68 Quite High
cva 8 67.88 Quite High
Somatostatin 4 57.04 Quite High
Inflammation 69 50.72 Quite High
Tendonitis 1 29.12 Quite Low
fibrosis 9 24.48 Low Low
Disease Link Frequency Relevance Heat
Osteoarthritis 15 97.08 Very High Very High Very High
Rupture 2 96.60 Very High Very High Very High
Burns 1 95.60 Very High Very High Very High
Knee Osteoarthritis 36 94.40 High High
Amyloid Plaque 7 94.32 High High
Synovitis 2 94.12 High High
Temporomandibular Joint Syndrome 3 91.64 High High
Apoptosis 18 88.04 High High
Temporomandibular Joint Disorders 1 75.00 Quite High
Pulmonary Disease 88 74.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the functional relevance of tPA variants are unknown, over expression of tPA leads to plasmin production, MMP activation and ECM degradation that is commonly associated with fetal membrane rupture and cervical ripening associated with PTB.
Positive_regulation (leads) of Gene_expression (production) of plasmin associated with rupture
1) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.30 Pain Relevance 0.07
Thrombin and plasmin cleave, thereby activating protease-activated receptor -1 (PAR-1) on macrophages.
Positive_regulation (activating) of Gene_expression (cleave) of plasmin in macrophages
2) Confidence 0.49 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.69 Pain Relevance 0
These results clearly demonstrated increased levels of PA, plasmin and kallikrein activities in the synovial fluid of patients with ID and OA, and suggest that these enzymes may be involved in the pathogenesis of synovitis, as well as the resorption of cartilage and bone in TMJ.
Positive_regulation (increased) of Gene_expression (levels) of plasmin in TMJ associated with snapping jaw, synovitis and osteoarthritis
3) Confidence 0.45 Published 2001 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 11518356 Disease Relevance 0.68 Pain Relevance 0.33
It increases the synthesis of MMPs and plasminogen activator, essential to convert the pro-MMPs in MMPs, and regulate the organization of ECM by enhancing the synthesis of minor collagens, normally not present in cartilage, such as collagen types I and III, and decreasing the production of proteoglycans and collagen types II and IX, which represent the optimal scaffolding of cartilage [3].
Positive_regulation (increases) of Gene_expression (synthesis) of plasminogen in cartilage associated with metalloproteinase
4) Confidence 0.06 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.37 Pain Relevance 0.37
Stimulation of plasminogen through tPA (tissue plasminogen activator) and the subsequent generation of plasmin reduces ?
Positive_regulation (Stimulation) of Gene_expression (through) of plasminogen
5) Confidence 0.03 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.46 Pain Relevance 0.12

General Comments

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