INT97777

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 9.85
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CNBP) endoplasmic reticulum (CNBP) nucleus (CNBP)
DNA binding (CNBP) cytoplasm (CNBP)
CNBP (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 26 100.00 Very High Very High Very High
Inflammation 80 93.20 High High
Pain 4 89.60 High High
sodium channel 1 74.40 Quite High
ischemia 11 70.80 Quite High
Tetrahydrobiopterin 12 55.28 Quite High
agonist 1 38.64 Quite Low
metalloproteinase 12 32.32 Quite Low
Inflammatory response 8 26.92 Quite Low
cva 43 22.72 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 160 100.00 Very High Very High Very High
Metabolic Syndrome 64 100.00 Very High Very High Very High
Prediabetic State 48 100.00 Very High Very High Very High
Impaired Glucose Tolerance 26 100.00 Very High Very High Very High
Stress 38 99.92 Very High Very High Very High
Disease 48 99.60 Very High Very High Very High
Systemic Lupus Erythematosus 61 98.78 Very High Very High Very High
Left Ventricular Hypertrophy 8 98.48 Very High Very High Very High
Muscle Weakness 2 97.92 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 6 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly to DM 1, anticipation also occurs in PROMM, but the disease course is usually milder.
Positive_regulation (occurs) of PROMM associated with disease
1) Confidence 0.37 Published 2001 Journal Nervenarzt Section Abstract Doc Link 11519202 Disease Relevance 2.16 Pain Relevance 0.13
Specifically, the pathway with the highest significance level, 'Activation of cAMP-dependent protein kinase, PKA (protein kinase A)' (Biocarta) was found in comparing DM2 and NGT (upregulated in DM2); the significance level, however, was calculated to be only p = 0.4.
Positive_regulation (upregulated) of DM2 associated with diabetes mellitus and tolerance
2) Confidence 0.07 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1261155 Disease Relevance 1.34 Pain Relevance 0.36
Specifically, the pathway with the highest significance level, 'Activation of cAMP-dependent protein kinase, PKA (protein kinase A)' (Biocarta) was found in comparing DM2 and NGT (upregulated in DM2); the significance level, however, was calculated to be only p = 0.4.
Positive_regulation (upregulated) of DM2 associated with diabetes mellitus and tolerance
3) Confidence 0.07 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1261155 Disease Relevance 1.34 Pain Relevance 0.36
The presence of target organ damage increases the risk of clinical cardiovascular complications in DM2.
Positive_regulation (increases) of DM2 associated with diabetes mellitus
4) Confidence 0.03 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2858115 Disease Relevance 1.27 Pain Relevance 0
Oxidative – redox stress is elevated in MS, PD, and T2DM and results in the production of reactive oxygen species (ROS).
Positive_regulation (elevated) of T2DM associated with stress, diabetes mellitus, prediabetic state and metabolic syndrome
5) Confidence 0.02 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 1.55 Pain Relevance 0.11
The Vv is called into the intima and media by a process of angiogenesis, which is increased in MS, PD, and overt T2DM.
Positive_regulation (increased) of T2DM associated with diabetes mellitus, prediabetic state and metabolic syndrome
6) Confidence 0.02 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 1.79 Pain Relevance 0.04
Since we are more concerned with SLE, we will concentrate on the signaling that takes place upon activation of nucleic acid-binding TLRs 3, 7/8, and 9.
Positive_regulation (activation) of nucleic acid-binding associated with systemic lupus erythematosus
7) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.41 Pain Relevance 0.09

General Comments

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