INT97779

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.45
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TSC2) signal transduction (TSC2) vesicle-mediated transport (TSC2)
Golgi apparatus (TSC2) nucleus (TSC2) intracellular (TSC2)
Anatomy Link Frequency
germline 1
TSC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 8 90.72 High High
Intractable pain 3 61.68 Quite High
cva 6 54.16 Quite High
headache 2 25.00 Low Low
Pain 2 5.00 Very Low Very Low Very Low
pain flank 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 121 100.00 Very High Very High Very High
Chordoma 131 99.00 Very High Very High Very High
Lymphangioleiomyomatosis 1 98.76 Very High Very High Very High
Convulsion 3 98.06 Very High Very High Very High
Intellectual Impairment 3 97.88 Very High Very High Very High
Nasal Tumor 1 97.48 Very High Very High Very High
Tuberous Sclerosis 10 97.36 Very High Very High Very High
Apoptosis 7 96.28 Very High Very High Very High
Disease 12 91.88 High High
Myeloid Leukemia 27 82.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to p53, tuberin is suggested to be the tumor suppressor in this tumor.
Negative_regulation (suppressor) of tuberin associated with cancer
1) Confidence 0.41 Published 2001 Journal J. Neurooncol. Section Abstract Doc Link 11519851 Disease Relevance 0.79 Pain Relevance 0
As reported above, the somatic loss of the wild-type TSC1 and TSC2 allele was found in the chordomas developed by two patients with Tuberous Sclerosis, carrying germline mutations of either TSC gene [13].
Negative_regulation (loss) of TSC2 in germline associated with tuberous sclerosis and chordoma
2) Confidence 0.20 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 1.25 Pain Relevance 0
TSC was suspected in patients with facial angiofibromas, mental retardation, seizure, or pulmonary lymphangiomyomatosis, and were categorized as definite when positive for TSC1 and TSC2 loss of heterozygosity.


Negative_regulation (loss) of TSC2 associated with convulsion, intellectual impairment, nasal tumor and lymphangioleiomyomatosis
3) Confidence 0.09 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908871 Disease Relevance 1.40 Pain Relevance 0.26

General Comments

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