INT97782

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Context Info
Confidence 0.86
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.27
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
satellite glial cells 3
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 4 96.20 Very High Very High Very High
dorsal root ganglion 9 91.60 High High
amygdala 57 89.80 High High
Anterior cingulate cortex 1 88.44 High High
Nerve growth factor 10 75.00 Quite High
isoflurane 2 52.88 Quite High
Pain 24 50.00 Quite Low
Opioid 14 50.00 Quite Low
Kinase C 3 39.88 Quite Low
nociceptor 9 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 16 93.96 High High
Ganglion Cysts 9 91.60 High High
Stupor 1 50.16 Quite High
Pain 25 50.00 Quite Low
Urological Neuroanatomy 5 50.00 Quite Low
Stress 1 14.56 Low Low
Anxiety Disorder 33 5.00 Very Low Very Low Very Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low
Neuropathic Pain 16 5.00 Very Low Very Low Very Low
Spinal Cord Injury 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, each branch seems to have a preferential activating stimulus: trophic factors for ERK, UV radiations for p38 and extracellular osmolarity for JNK [14].
Protein_catabolism (radiations) of ERK
1) Confidence 0.86 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0 Pain Relevance 0
In contrast pERK is prominent in a few trkA cells and in satellite glial cells, and is further increased by NGF treatment. tERK and pERK both undergo fast anterograde and retrograde axonal transport, indicated by accumulation at a sciatic nerve ligature, and NGF reduces the level of retrograde pERK transport.
Protein_catabolism (treatment.) of tERK in satellite glial cells associated with sciatic nerve
2) Confidence 0.54 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11520179 Disease Relevance 0.40 Pain Relevance 0.20
In contrast pERK is prominent in a few trkA cells and in satellite glial cells, and is further increased by NGF treatment. tERK and pERK both undergo fast anterograde and retrograde axonal transport, indicated by accumulation at a sciatic nerve ligature, and NGF reduces the level of retrograde pERK transport.
Protein_catabolism (prominent) of pERK in satellite glial cells associated with sciatic nerve
3) Confidence 0.54 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11520179 Disease Relevance 0.42 Pain Relevance 0.21
Our pilot data using immunocytochemistry showed that subregions of the mPFC (infralimbic, prelimbic, and cingulate gyrus) all showed increased pERK upon extinction training.
Protein_catabolism (showed) of pERK
4) Confidence 0.50 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.05 Pain Relevance 0.15
In contrast pERK is prominent in a few trkA cells and in satellite glial cells, and is further increased by NGF treatment. tERK and pERK both undergo fast anterograde and retrograde axonal transport, indicated by accumulation at a sciatic nerve ligature, and NGF reduces the level of retrograde pERK transport.
Protein_catabolism (treatment.) of pERK in satellite glial cells associated with sciatic nerve
5) Confidence 0.24 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11520179 Disease Relevance 0.40 Pain Relevance 0.20

General Comments

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