INT97782

Context Info Confidence 0.86 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 1.27 Pain Relevance 0.76

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1) cytoplasm (Ephb1)

Anatomy Link Frequency satellite glial cells 3 Ephb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Sciatic nerve 4 96.20 dorsal root ganglion 9 91.60 amygdala 57 89.80 Anterior cingulate cortex 1 88.44 Nerve growth factor 10 75.00 isoflurane 2 52.88 Pain 24 50.00 Opioid 14 50.00 Kinase C 3 39.88 nociceptor 9 25.00

Disease Link Frequency Relevance Heat Nociception 16 93.96 Ganglion Cysts 9 91.60 Stupor 1 50.16 Pain 25 50.00 Urological Neuroanatomy 5 50.00 Stress 1 14.56 Anxiety Disorder 33 5.00 INFLAMMATION 16 5.00 Neuropathic Pain 16 5.00 Spinal Cord Injury 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, each branch seems to have a preferential activating stimulus: trophic factors for ERK, UV radiations for p38 and extracellular osmolarity for JNK [14].

Protein_catabolism (radiations) of ERK

1) Confidence 0.86 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0 Pain Relevance 0

In contrast pERK is prominent in a few trkA cells and in satellite glial cells, and is further increased by NGF treatment. tERK and pERK both undergo fast anterograde and retrograde axonal transport, indicated by accumulation at a sciatic nerve ligature, and NGF reduces the level of retrograde pERK transport.

Protein_catabolism (treatment.) of tERK in satellite glial cells associated with sciatic nerve

2) Confidence 0.54 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11520179 Disease Relevance 0.40 Pain Relevance 0.20

In contrast pERK is prominent in a few trkA cells and in satellite glial cells, and is further increased by NGF treatment. tERK and pERK both undergo fast anterograde and retrograde axonal transport, indicated by accumulation at a sciatic nerve ligature, and NGF reduces the level of retrograde pERK transport.

Protein_catabolism (prominent) of pERK in satellite glial cells associated with sciatic nerve

3) Confidence 0.54 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11520179 Disease Relevance 0.42 Pain Relevance 0.21

Our pilot data using immunocytochemistry showed that subregions of the mPFC (infralimbic, prelimbic, and cingulate gyrus) all showed increased pERK upon extinction training.

Protein_catabolism (showed) of pERK

4) Confidence 0.50 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.05 Pain Relevance 0.15

In contrast pERK is prominent in a few trkA cells and in satellite glial cells, and is further increased by NGF treatment. tERK and pERK both undergo fast anterograde and retrograde axonal transport, indicated by accumulation at a sciatic nerve ligature, and NGF reduces the level of retrograde pERK transport.

Protein_catabolism (treatment.) of pERK in satellite glial cells associated with sciatic nerve

5) Confidence 0.24 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11520179 Disease Relevance 0.40 Pain Relevance 0.20

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