INT97789

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Context Info
Confidence 0.12
First Reported 2001
Last Reported 2001
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1, Nos2) peroxisome (Nos2) intracellular (Nos2)
cytoplasm (Nos2) response to stress (Cnr1) signal transducer activity (Cnr1)
Anatomy Link Frequency
glial cells 3
Cnr1 (Rattus norvegicus)
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 4 99.98 Very High Very High Very High
Inflammation 1 97.16 Very High Very High Very High
antagonist 2 89.84 High High
Potency 1 72.24 Quite High
agonist 1 52.80 Quite High
Cannabinoid receptor 1 52.44 Quite High
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 97.16 Very High Very High Very High
Glioma 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that selective cannabinoid CB1 receptor activation, by inhibiting iNOS expression and NO overproduction in glial cells, might be helpful in NO-mediated inflammation leading to neurodegeneration.
Spec (1475) Positive_regulation (activation) of CB1 receptor in glial cells Negative_regulation (inhibiting) of Gene_expression (expression) of iNOS in glial cells associated with inflammation and cannabinoid
1) Confidence 0.12 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11520904 Disease Relevance 0.23 Pain Relevance 0.40

General Comments

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