INT9779

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 23
Total Number 24
Disease Relevance 8.01
Pain Relevance 6.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Glb1) carbohydrate metabolic process (Glb1) lysosome (Glb1)
Anatomy Link Frequency
bone marrow 1
skeletal muscle 1
blood 1
hypothalamus 1
HeLa 1
Glb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
Chronic pancreatitis 9 99.84 Very High Very High Very High
Morphine 15 99.70 Very High Very High Very High
Ventral tegmentum 11 99.68 Very High Very High Very High
COX2 26 99.28 Very High Very High Very High
withdrawal 5 98.72 Very High Very High Very High
addiction 2 98.44 Very High Very High Very High
Locus ceruleus 10 98.24 Very High Very High Very High
nociceptor 1 98.00 Very High Very High Very High
opiate 4 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 51 99.88 Very High Very High Very High
Pancreatitis 9 99.84 Very High Very High Very High
Malignant Neoplastic Disease 6 99.44 Very High Very High Very High
Stress 18 99.22 Very High Very High Very High
Gastrointestinal Neoplasms 3 99.08 Very High Very High Very High
Morphine Dependence 1 98.44 Very High Very High Very High
Volume Depletion And Dehydration 4 96.60 Very High Very High Very High
Opiate Addiction 1 94.16 High High
Pancreatic Cancer 9 93.28 High High
Cancer 65 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Flanking regulatory sequences of the locus encoding the murine GDNF receptor, c-ret, directs lac Z (beta-galactosidase) expression in developing somatosensory system.
Gene_expression (expression) of beta-galactosidase associated with nociceptor
1) Confidence 0.58 Published 2001 Journal Dev. Dyn. Section Title Doc Link 11747074 Disease Relevance 0.07 Pain Relevance 0.10
This advantage is ascribed to the presence of living lactic acid bacteria in fermented dairy products which survive passage through the stomach and also to the lactase present in these products.
Gene_expression (present) of lactase in stomach
2) Confidence 0.56 Published 1997 Journal Z Ernahrungswiss Section Abstract Doc Link 9467238 Disease Relevance 0.40 Pain Relevance 0.10
Expression and regulation of a proenkephalin beta-galactosidase fusion gene in the reproductive system of transgenic mice.
Gene_expression (Expression) of beta-galactosidase in reproductive system associated with targeted disruption and enkephalin
3) Confidence 0.42 Published 1992 Journal Mol. Endocrinol. Section Title Doc Link 1435791 Disease Relevance 0.26 Pain Relevance 0.20
These oligopeptides (dipeptides to hexapeptides) were analyzed as cations in two acidic background electrolytes (BGEs), BGE I (100mM H3PO4, 50mM Tris, pH 2.25), BGE II (100mM iminodiacetic acid, pH 2.30), and both as cations and anions in alkaline BGE IV (40 mM Tris, 40 mM Tricine, pH 8.10).
Spec (analyzed) Gene_expression (cations) of BGE
4) Confidence 0.41 Published 2005 Journal J Chromatogr A Section Abstract Doc Link 16013591 Disease Relevance 0 Pain Relevance 0.49
We show here that chronic (but not acute) exposure of the TH9.0-LacZ mice to morphine increases the expression of beta-galactosidase (which is encoded by the LacZ gene) in the locus coeruleus by twofold compared with sham-treated mice.
Gene_expression (expression) of beta-galactosidase in locus coeruleus associated with locus ceruleus and morphine
5) Confidence 0.40 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822754 Disease Relevance 0.17 Pain Relevance 0.89
In contrast, beta-galactosidase expression in the ventral tegmental area was decreased 20-25% by chronic morphine and unaffected by chronic cocaine administration.
Gene_expression (expression) of beta-galactosidase in ventral associated with ventral tegmentum, cocaine and morphine
6) Confidence 0.40 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822754 Disease Relevance 0.16 Pain Relevance 0.90
Bacterial beta-galactosidase and human dystrophin genes are expressed in mouse skeletal muscle fibers after ballistic transfection.
Gene_expression (expressed) of beta-galactosidase in skeletal muscle
7) Confidence 0.27 Published 1997 Journal FEBS Lett. Section Title Doc Link 9315710 Disease Relevance 0.17 Pain Relevance 0.07
To test the pathophysiology of CUG repeat encoding RNAs, we developed and analyzed mice with cardiac-specific expression of a beta-galactosidase cassette in which a (CTG)400 repeat tract was positioned 3?
Gene_expression (expression) of beta-galactosidase
8) Confidence 0.27 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2597774 Disease Relevance 0.17 Pain Relevance 0
To determine whether these adaptations ultimately affect transcription mediated by the cAMP response element (CRE), we induced morphine dependence in CRE-LacZ transgenic mice and performed a regional and cellular mapping of beta-galactosidase (beta-gal) expression during naltrexone-precipitated withdrawal.
Gene_expression (expression) of beta-galactosidase associated with targeted disruption, addiction, withdrawal and morphine
9) Confidence 0.25 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.29 Pain Relevance 1.00
Here, the authors used a transgenic mouse model in which expression of a readily measurable beta-galactosidase reporter was driven in PVN neurons by human proenkephalin regulatory sequences.
Gene_expression (expression) of beta-galactosidase in neurons associated with targeted disruption
10) Confidence 0.24 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10023810 Disease Relevance 0.10 Pain Relevance 0.05
To test the pathophysiology of CUG repeat encoding RNAs, we developed and analyzed mice with cardiac-specific expression of a beta-galactosidase cassette in which a (CTG)400 repeat tract was positioned 3?
Gene_expression (cassette) of beta-galactosidase
11) Confidence 0.23 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2597774 Disease Relevance 0.17 Pain Relevance 0
To examine the effects of these modulators at the cellular level, the current study utilized a transgenic mouse line that expresses a human proenkephalin promoter/bacterial beta-galactosidase fusion gene (ENK-1).
Gene_expression (expresses) of beta-galactosidase associated with targeted disruption
12) Confidence 0.22 Published 1997 Journal J. Neuroendocrinol. Section Abstract Doc Link 9147295 Disease Relevance 0.26 Pain Relevance 0.07
Pre-existing immunity to adenovirus serotype 5 was established by injecting 5×1010 particles of adenovirus expressing beta-galactosidase (AdlacZ) by intramuscular injection in the right hindlimb 30 days prior to vaccination with Ad5-ZGP.
Gene_expression (expressing) of beta-galactosidase in hindlimb
13) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2569416 Disease Relevance 0.35 Pain Relevance 0.13
Each dilution (100 µl) was mixed with an aliquot of a standard stock of adenovirus type 5 expressing E. coli beta-galactosidase (106 pfu), incubated for 1 hour at 37°C, and applied to HeLa cells in 96-well plates (2×104 cells/well).
Gene_expression (expressing) of beta-galactosidase in HeLa
14) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2569416 Disease Relevance 0.12 Pain Relevance 0
Estrogen and stress interact to regulate the hypothalamic expression of a human proenkephalin promoter-beta-galactosidase fusion gene in a site-specific and sex-specific manner.
Gene_expression (expression) of beta-galactosidase associated with stress and enkephalin
15) Confidence 0.19 Published 1997 Journal J. Neuroendocrinol. Section Title Doc Link 9147295 Disease Relevance 0.26 Pain Relevance 0.17
Pre-existing immunity was induced by intramuscular administration of recombinant Ad5 expressing a non-relevant antigen, beta-galactosidase (AdlacZ), 30 days prior to vaccination with Ad5-ZGP.
Gene_expression (expressing) of beta-galactosidase
16) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2569416 Disease Relevance 0.75 Pain Relevance 0
One of the first observations that bone marrow contains high numbers of endothelial progenitor cells was by Ashara et al using infusion of bone marrow cells in which the beta-galactosidase marker was expressed under control of endothelial cell-specific promoters such as Flk-1 and Tie-2.
Gene_expression (expressed) of beta-galactosidase in bone marrow
17) Confidence 0.09 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0.60 Pain Relevance 0.21
Transgenic mice expressing an Escherichia coli beta-galactosidase reporter gene under the control of 3 kilobases of human proenkephalin gene 5'-flanking sequence and 1.2 kilobases of 3'-flanking sequence exhibited an anatomically correct pattern of basal and stress-regulated transgene expression within the hypothalamus.
Gene_expression (expressing) of beta-galactosidase reporter gene in hypothalamus associated with stress and targeted disruption
18) Confidence 0.08 Published 1994 Journal Mol. Endocrinol. Section Abstract Doc Link 8152426 Disease Relevance 0.57 Pain Relevance 0
Certain alterations of blood group substance (BGS) expression have been observed in gastrointestinal cancer tissues.
Gene_expression (expression) of BGS in blood associated with gastrointestinal neoplasms
19) Confidence 0.07 Published 1987 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 2442445 Disease Relevance 0.41 Pain Relevance 0.08
However, in the pancreas little is known about BGS expression by normal or malignant tissue.
Gene_expression (expression) of BGS in pancreas associated with malignant neoplastic disease
20) Confidence 0.07 Published 1987 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 2442445 Disease Relevance 0.49 Pain Relevance 0.14

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