INT97795

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Context Info
Confidence 0.09
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.57
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (TNF) extracellular matrix organization (TNF) DNA binding (IRF6)
cytoplasm (IRF6) cytosol (IRF6) signal transduction (TNF)
Anatomy Link Frequency
blood 2
adipocytes 2
IRF6 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 13 98.96 Very High Very High Very High
lidocaine 2 91.44 High High
antagonist 15 87.88 High High
Inflammation 65 84.88 Quite High
Kinase C inhibitor 3 83.12 Quite High
cytokine 74 71.56 Quite High
anesthesia 3 42.00 Quite Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 204 99.80 Very High Very High Very High
INFLAMMATION 65 84.88 Quite High
Overweight 3 52.96 Quite High
Diabetes Mellitus 6 47.32 Quite Low
Metabolic Syndrome 6 45.44 Quite Low
Disease 12 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Insulin Resistance 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also tested the effects of these amphipathic molecules on the LPS-neutralizing activity of RsLPS and E5564 on LPS-induced TNF-alpha release in human whole blood.
LPS Positive_regulation (induced) of Localization (release) of TNF-alpha in blood
1) Confidence 0.09 Published 2000 Journal J. Endotoxin Res. Section Abstract Doc Link 11521069 Disease Relevance 0.08 Pain Relevance 0.52
The activation of TNFalpha secretion by LPS is receptor specific and dependent upon the bacterial endotoxin binding to the TLR4 receptor [8].
LPS Positive_regulation (activation) of Localization (secretion) of TNFalpha
2) Confidence 0.07 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.15 Pain Relevance 0.04
In the first part of this study, we identified the TLR4 signalling pathways activated by LPS (NFkappaB and p38 MAP Kinase), which lead to the secretion of TNFalpha by mature human adipocytes.
LPS Positive_regulation (lead) of Localization (secretion) of TNFalpha in adipocytes associated with obesity
3) Confidence 0.06 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 1.09 Pain Relevance 0.12
In the work that is presented here, we show in detail the principal activation regulation pathways of the LPS induced secretion of TNFalpha.
LPS Positive_regulation (induced) of Localization (secretion) of TNFalpha
4) Confidence 0.05 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.25 Pain Relevance 0
Similarly, ATP inhibits LPS-induced release of TNF?
LPS Positive_regulation (induced) of Localization (release) of TNF
5) Confidence 0.04 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.18

General Comments

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