INT97797

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 18
Total Number 22
Disease Relevance 13.78
Pain Relevance 6.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4) plasma membrane (TLR4) intracellular (TLR4)
cytoplasm (TLR4)
Anatomy Link Frequency
endometrium 2
leukocyte 2
monocyte 2
corneal epithelial cells 2
macrophages 1
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 403 100.00 Very High Very High Very High
cytokine 303 100.00 Very High Very High Very High
Opioid 67 100.00 Very High Very High Very High
antagonist 36 99.78 Very High Very High Very High
agonist 140 99.76 Very High Very High Very High
chemokine 60 99.66 Very High Very High Very High
analgesia 20 98.12 Very High Very High Very High
endometriosis 126 95.20 Very High Very High Very High
rheumatoid arthritis 113 95.12 Very High Very High Very High
Inflammatory response 79 95.00 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 483 100.00 Very High Very High Very High
Endometrial Cancer 24 100.00 Very High Very High Very High
Hyperplasia 19 100.00 Very High Very High Very High
Carcinoma 48 99.72 Very High Very High Very High
Endometriosis (extended) 228 99.60 Very High Very High Very High
Injury 234 99.40 Very High Very High Very High
Infection 79 99.20 Very High Very High Very High
Apoptosis 47 99.12 Very High Very High Very High
Hepatitis C Virus Infection 20 99.00 Very High Very High Very High
Papillomavirus Infection 8 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with Pioli et al., who detected TLR4, CD14 and MyD88 transcripts in human endometrium [14], we were able to co-localize TLR4 with CD14 proteins suggesting the presence of both interacting receptors CD14 and TLR4 in the endometrial cells.
Localization (localize) of TLR4 in endometrium
1) Confidence 0.77 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.19 Pain Relevance 0.06
In accordance with staining patterns obtained during the menstrual phase (figure 2J), we were able to find TLR4 protein localized on immune cells (figure 6F, G, H, I).
Localization (localized) of TLR4 protein in immune cells
2) Confidence 0.77 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.90 Pain Relevance 0
S. flexneri triggers an acute inflammation in part due 1) to apoptosis of monocytes and macrophages, which widely release pro-inflammatory cytokines and 2) to the stimulation of the innate immune response via the activation of Nod- and Toll-like receptors by bacterial cell components [6].
Spec (like) Localization (release) of Toll in monocytes associated with inflammation, apoptosis and cytokine
3) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2653194 Disease Relevance 1.12 Pain Relevance 0.29
In agreement with Pioli et al., who detected TLR4, CD14 and MyD88 transcripts in human endometrium [14], we were able to co-localize TLR4 with CD14 proteins suggesting the presence of both interacting receptors CD14 and TLR4 in the endometrial cells.
Localization (presence) of TLR4 in endometrium
4) Confidence 0.72 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.31 Pain Relevance 0.08
In undifferentiated G3 carcinoma, staining for TLR3 (figure 6E) and TLR4 (figure 6J) was not detectable, strengthening our findings of low TLR3 and TLR4 mRNA abundance in G3 carcinoma (figure 5B).
Localization (abundance) of TLR4 mRNA associated with carcinoma
5) Confidence 0.72 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.94 Pain Relevance 0
TLR3 and TLR4 mRNA abundance in healthy postmenopausal tissues is similar to those found during the menstrual cycle.
Localization (abundance) of TLR4 mRNA
6) Confidence 0.72 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.66 Pain Relevance 0.08
TLR3 and TLR4 proteins in hyperplasia and endometrial carcinoma were mostly localized to the luminal and glandular epithelium (figure 6).
Localization (localized) of TLR4 in epithelium associated with endometrial cancer and hyperplasia
7) Confidence 0.72 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 1.00 Pain Relevance 0.03
We will now review the roles of other mediators of inflammation such as complement, chemokines, cytokines, and toll-like receptors (TLRs) that regulate or are released by the renal tubular epithelial cells, renal endothelial cells, and inflammatory cells.

4.

Localization (released) of toll in endothelial cells associated with chemokine, inflammation and cytokine
8) Confidence 0.68 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.55 Pain Relevance 0.67
It induces, through stimulation of Toll-like receptors (TLRs) localized on the surface of antigen-presenting cells, synthesis and release of several endogenous pro-inflammatory cytokines such as interferon-?
Localization (localized) of Toll associated with inflammation and cytokine
9) Confidence 0.68 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2503670 Disease Relevance 0.59 Pain Relevance 0.10
AM3, a mixture containing immunoregulatory glycoconjugates, induces functional maturation of monocyte-derived DCs from patients with chronic HCV infection and healthy donors, and stimulates the secretion of molecules with antiviral properties in a TLR4-dependent manner [82].


Localization (secretion) of TLR4 in monocyte associated with hepatitis c virus infection and infection
10) Confidence 0.66 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.63 Pain Relevance 0.26
LPS stimulates TLR4 on KCs to enhance hepatocyte damage, increase leukocyte infiltration and secrete pro-fibrogenic cytokines.
Localization (secrete) of TLR4 in leukocyte associated with agonist and cytokine
11) Confidence 0.66 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.13 Pain Relevance 0.89
First of all, we must acknowledge that TLR2, TLR3 and TLR4 appear to be localized mainly in the apical part of the epithelium. mRNA from nasal biopsies is comprised of a heterogeneous mix of different cells not only from the epithelium, but also from the submucosa.
Localization (localized) of TLR4 in nasal
12) Confidence 0.64 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.08 Pain Relevance 0
The effects of LPS and these synthetic antagonists have been localized to the recently described Toll-like receptor 4 (TLR4).
Localization (localized) of TLR4 associated with antagonist
13) Confidence 0.63 Published 2000 Journal J. Endotoxin Res. Section Abstract Doc Link 11521069 Disease Relevance 0.09 Pain Relevance 0.37
The effects of LPS and these synthetic antagonists have been localized to the recently described Toll-like receptor 4 (TLR4).
Localization (localized) of Toll-like receptor 4 associated with antagonist
14) Confidence 0.63 Published 2000 Journal J. Endotoxin Res. Section Abstract Doc Link 11521069 Disease Relevance 0.09 Pain Relevance 0.37
Quantitative real-time PCR (qRT-PCR, TaqMan) was performed to determine the relative TLR2, TLR4 and TLR9 mRNA expression levels using the comparative threshold cycle (??
Spec (determine) Localization (relative) of TLR4
15) Confidence 0.63 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0
TLR4 is a possible receptor for endogenous factors released during tissue injury and infammation, such as hsp60 [77].
Localization (released) of TLR4 associated with injury
16) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.79 Pain Relevance 0.35
However, a later report from Ueta et al. [17] showed that LPS incubation had no effect on TLR4 surface distribution or IL-6 and IL-8 secretion in either primary cultured or immortalized human corneal epithelial cells.
Localization (secretion) of TLR4 in corneal epithelial cells
17) Confidence 0.55 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.16 Pain Relevance 0.12
However, a later report from Ueta et al. [17] showed that LPS incubation had no effect on TLR4 surface distribution or IL-6 and IL-8 secretion in either primary cultured or immortalized human corneal epithelial cells.
Localization (distribution) of TLR4 in corneal epithelial cells
18) Confidence 0.55 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.15 Pain Relevance 0.12
healthy controls could be explained by increased expression of TLR4 receptors
Localization (receptors) of TLR4
19) Confidence 0.52 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2435281 Disease Relevance 1.23 Pain Relevance 0.45
S. flexneri triggers an acute inflammation in part due 1) to apoptosis of monocytes and macrophages, which widely release pro-inflammatory cytokines and 2) to the stimulation of the innate immune response via the activation of Nod- and Toll-like receptors by bacterial cell components [6].
Spec (like) Localization (release) of Toll in macrophages associated with inflammation, apoptosis and cytokine
20) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2653194 Disease Relevance 1.12 Pain Relevance 0.29

General Comments

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