INT97798

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Context Info
Confidence 0.73
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 86
Total Number 88
Disease Relevance 33.27
Pain Relevance 20.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
Anatomy Link Frequency
monocytes 10
macrophages 6
neutrophils 6
corneal epithelial cells 4
THP-1 3
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1560 100.00 Very High Very High Very High
agonist 331 100.00 Very High Very High Very High
Inflammatory stimuli 75 100.00 Very High Very High Very High
rheumatoid arthritis 145 99.98 Very High Very High Very High
Inflammation 1702 99.96 Very High Very High Very High
Morphine 1239 99.92 Very High Very High Very High
dexamethasone 225 99.74 Very High Very High Very High
Inflammatory response 281 99.64 Very High Very High Very High
aspirin 242 99.64 Very High Very High Very High
Bile 18 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 146 99.98 Very High Very High Very High
INFLAMMATION 2042 99.96 Very High Very High Very High
Asthma 317 99.92 Very High Very High Very High
Hantavirus Infection 78 99.80 Very High Very High Very High
Chronic Fatigue Syndrome 300 99.62 Very High Very High Very High
Obesity 373 99.56 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 255 99.50 Very High Very High Very High
Mycobacterial Infection 46 99.44 Very High Very High Very High
Sepsis 371 99.34 Very High Very High Very High
Adhesions 82 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared with nonresponders, subjects achieving a > or = 30% reduction in ICSI were more likely to be pleased with PPS for IC symptoms, to have benefited from PPS for their IC symptoms, to recommend PPS for IC symptoms to others with the same condition, and to say that PPS provides better relief, based on prior experience with other IC treatments.
Localization (pleased) of PPS
1) Confidence 0.73 Published 2008 Journal Curr Med Res Opin Section Body Doc Link 18582395 Disease Relevance 0.07 Pain Relevance 0
R,R-Glycopyrrolate alone did not affect LPS induced TNF-alpha release.
Localization (release) of LPS
2) Confidence 0.68 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16996482 Disease Relevance 0.69 Pain Relevance 0.27
We also show in mature human adipocytes that unlike human monocytes/macrophages (in primary culture or immortalized cell lines), the p42/44 MAP Kinase, JNK or PKA pathways are not implicated in the secretion of LPS induced TNFalpha [11-14,26,27].
Localization (secretion) of LPS in macrophages associated with obesity
3) Confidence 0.40 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.30 Pain Relevance 0
These in silico results lie in agreement with studies [31] that suggest a dose-dependent decrease in LPS-induced TNF in peripheral human blood leukocytes that are exposed to hydrocortisone infusion.
Localization (decrease) of LPS in leukocytes associated with inflammatory stimuli
4) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.49 Pain Relevance 0.59
M) strongly increases the activation of LPS induced TNFalpha secretion (more than 2-fold).
Localization (secretion) of LPS
5) Confidence 0.37 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.05 Pain Relevance 0.04
Furthermore, our results demonstrate that PI3K is partially implicated in LPS-activated adipocytes.
Localization (implicated) of LPS in adipocytes associated with obesity
6) Confidence 0.33 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.26 Pain Relevance 0
In the work that is presented here, we show in detail the principal activation regulation pathways of the LPS induced secretion of TNFalpha.
Localization (secretion) of LPS
7) Confidence 0.33 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.25 Pain Relevance 0
A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages

Background

Localization (release) of LPS in monocytes associated with aspirin
8) Confidence 0.29 Published 2008 Journal J Inflamm (Lond) Section Title Doc Link PMC2525633 Disease Relevance 0.17 Pain Relevance 0.35
In Gram-negative sepsis, endotoxin (lipopolysaccharide (LPS)) released from bacteria stimulates transcriptional factors to activate the inflammation and coagulation systems [2].
Localization (released) of LPS associated with inflammation and sepsis
9) Confidence 0.28 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.78 Pain Relevance 0.17
For consistency, LPS was used as our NF-?
Localization (used) of LPS
10) Confidence 0.26 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0 Pain Relevance 0.08
release from LPS-stimulated monocytes but this was at concentrations of 5–10 mM [49], which may not be representative of pharmacologically relevant plasma concentrations [51].
Localization (release) of LPS in plasma
11) Confidence 0.26 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0.15 Pain Relevance 0.33
release from LPS-stimulated monocytes or macrophages.
Localization (release) of LPS in macrophages
12) Confidence 0.26 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0.18 Pain Relevance 0.39
COX-2 and in part COX-1-selective inhibitors inhibited LPS-induced PGE(2) secretion, whereas the AA-induced PGE(2) secretion was reduced by COX-1-selective inhibitors only.
Localization (secretion) of LPS
13) Confidence 0.22 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.61 Pain Relevance 0.31
In line with this, we demonstrated a higher release of IL-8 by LPS stimulated blood cells after smoking, which may have contributed to increased neutrophil chemotaxis.
Localization (release) of LPS in neutrophil associated with nicotine addiction
14) Confidence 0.19 Published 2005 Journal Respir Res Section Body Doc Link PMC554761 Disease Relevance 0.81 Pain Relevance 0.03
Inhibition of LPS-induced cytokine release by Prolastin was concentration-dependent and was typically observed over a concentration range of 0.5–16 mg/ml.
Localization (release) of LPS associated with cytokine
15) Confidence 0.19 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0 Pain Relevance 0.09
Effects of low concentration of morphine on LPS-induced IL-8 secretion from human neutrophils were also studied.
Localization (secretion) of LPS in neutrophils associated with morphine
16) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0.42 Pain Relevance 1.13
In earlier work, we showed that LPS-induced secretion of cytokines could be blocked by corticosteroids like dexamethasone [16].


Localization (secretion) of LPS associated with corticosteroid, dexamethasone and cytokine
17) Confidence 0.19 Published 2008 Journal Proteome Sci Section Body Doc Link PMC2413206 Disease Relevance 0.26 Pain Relevance 0.33
Thus, following LPS stimulation astrocytes release significant amount of prostaglandin E [74], whereas microglia express prostaglandin receptors [75] and express cyclooxygenase 2 [76].
Localization (release) of LPS in microglia associated with cox2
18) Confidence 0.19 Published 2005 Journal Crit Care Section Body Doc Link PMC1065096 Disease Relevance 0.37 Pain Relevance 0.37
This suggests that in this model of natural LPS release, the variation between individuals in TNF-alpha release can only modestly be determined by genetic background (TNF-alpha promoter, Nod2 and TLR4) of the individual.
Localization (release) of LPS
19) Confidence 0.18 Published 2004 Journal Cytokine Section Abstract Doc Link 15016407 Disease Relevance 0.51 Pain Relevance 0.11
Individuals exhibiting both the highest and lowest COMT activity were homozygous for the val158 allele, which is present in both the LPS and HPS haplotypes.
Localization (present) of LPS associated with catechol-o-methyltransferase and hantavirus infection
20) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.55 Pain Relevance 0.20

General Comments

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