INT97799

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Context Info
Confidence 0.26
First Reported 2000
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 6.54
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
Anatomy Link Frequency
macrophages 3
ventricle 1
blood 1
lung 1
body 1
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 390 100.00 Very High Very High Very High
agonist 81 100.00 Very High Very High Very High
tolerance 22 99.60 Very High Very High Very High
aspirin 192 98.84 Very High Very High Very High
rheumatoid arthritis 168 95.92 Very High Very High Very High
anesthesia 14 95.44 Very High Very High Very High
lidocaine 4 95.20 Very High Very High Very High
Inflammation 440 93.92 High High
dexamethasone 20 92.32 High High
antagonist 35 91.64 High High
Disease Link Frequency Relevance Heat
Cancer 36 100.00 Very High Very High Very High
Necrosis 33 100.00 Very High Very High Very High
Cirrhosis 62 98.88 Very High Very High Very High
Hypersensitivity 9 98.12 Very High Very High Very High
Shock 8 97.12 Very High Very High Very High
Rheumatoid Arthritis 169 95.92 Very High Very High Very High
Stroke 8 94.88 High High
INFLAMMATION 524 93.92 High High
Sepsis 133 93.60 High High
Emphysema 47 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, this peptidomimetic compound did not show any effect on LPS induced MAPK activation.
Regulation (effect) of LPS
1) Confidence 0.26 Published 2003 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 12784915 Disease Relevance 0 Pain Relevance 0.15
Treatment with LY294002 leads to a 15% down-regulation of LPS-induced TNFalpha secretion (Figure 4A2).


Regulation (regulation) of LPS
2) Confidence 0.20 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.09 Pain Relevance 0.04
Moreover, infusion of rhAPC had no significant effects on the LPS-induced changes in right atrial pressure, heart rate, mean systemic arterial pressure, systemic vascular resistance index, CI, stroke volume index, LAP, and left and right ventricle stroke work indices in any of the groups (Table 1).
Neg (no) Regulation (effects) of LPS in ventricle associated with stroke
3) Confidence 0.18 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.36 Pain Relevance 0
release we investigated the effect of the compound on LPS-stimulated NF-?
Spec (investigated) Regulation (effect) of LPS
4) Confidence 0.16 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0.08 Pain Relevance 0.06
While the literature on the biological activity of heterotrophic bacterial LPS is overwhelmingly large and therefore difficult to review for the purposes of exclusion, we were unable to find a convincing body of evidence to suggest that heterotrophic bacterial LPS, in the absence of other virulence factors, is responsible for acute gastrointestinal, dermatological or allergic reactions via natural exposure routes in humans.
Regulation (responsible) of LPS in body associated with hypersensitivity
5) Confidence 0.14 Published 2006 Journal Environ Health Section Abstract Doc Link PMC1489932 Disease Relevance 0.15 Pain Relevance 0.07
A potential mechanism whereby endotoxin-tolerance develops is a down-regulation of LPS receptors such as membrane CD14 on macrophages [70].
Regulation (regulation) of LPS in macrophages associated with tolerance
6) Confidence 0.13 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.59 Pain Relevance 0.42
Earlier studies have shown that lesions within the PIT affect monkeys’ ability of shape discrimination (Iwai and Mishkin 1969) and visual attention (De Weerd et al. 1999); however, selective lesion of the PIT has failed to cause a clear deficit in color discrimination (Huxlin et al. 2000).
Regulation (affect) of PIT
7) Confidence 0.11 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2882824 Disease Relevance 0 Pain Relevance 0
Pre-incubation with the NO-aspirin B8 gave a dramatic shift in the staining compared to the LPS control.
Regulation (control) of LPS associated with aspirin
8) Confidence 0.10 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0 Pain Relevance 0.09
release in human monocyte-derived macrophages treated with LPS (36 ± 10% of LPS control, P <0.01; n = 5–10 separate donors, Fig. 2).
Regulation (control) of LPS in macrophages
9) Confidence 0.10 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0 Pain Relevance 0.09
release in human monocyte-derived macrophages treated with LPS (36 ± 10% of LPS control, P <0.01; n = 5–10 separate donors, Fig. 2).
Regulation (control) of LPS in macrophages
10) Confidence 0.10 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0 Pain Relevance 0.09
Exposure to LPS stimulated increased IL-6 release from the amniotic and choriodecidual sides of the membranes (Fig. 2B; ANOVA LPS treatment effect, p = 0.008), but the pattern of IL-6 response was different for the amniotic versus the choriodecidual side of the membranes depending on the treatment modality (ANOVA treatment * membrane side interaction, p = 0.03).
Regulation (effect) of LPS
11) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0 Pain Relevance 0
These results show that LPS treatment of only the amniotic side of the gestational membranes stimulated a similar IL-6 response on the amniotic and choriodecidual sides of the membranes, but that the converse was not true for LPS treatment of only the choriodecidual side which stimulated increased IL-6 release on the choriodecidual side only.


Neg (not) Regulation (true) of LPS
12) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0 Pain Relevance 0
response, no difference in LPS-induced TNF-?
Neg (no) Regulation (difference) of LPS
13) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.89 Pain Relevance 0.46
LTA and LPS, at the concentration range of 10 ng/ml to 10 ?
Regulation (range) of LPS
14) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0
in response to LPS challenge.
Regulation (response) of LPS
15) Confidence 0.04 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.06
Absence of TLR4 or expression of the TLR4 T399I and/or D299G SNPs confers reduced LPS responsiveness in cultured human or mouse HSCs [72].
Regulation (responsiveness) of LPS associated with cirrhosis and agonist
16) Confidence 0.03 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.58 Pain Relevance 0.48
The data suggest that the LPS/tumor necrosis factor-alpha- (TNF-alpha) dependent regulation of miR-155 and miR-125b may be implicated in the response to endotoxin shock, thus offering new targets for drug design [13].
Regulation (regulation) of LPS associated with necrosis, cancer and shock
17) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 1.04 Pain Relevance 0.03
As shown in Fig. 2, pretreatment (1 hr) of SP600125 strongly suppressed the inhibitory effect of melittin and bee venom on the LPS and SNP-induced NF-?
Regulation (effect) of LPS
18) Confidence 0.03 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0 Pain Relevance 0
B, pretreatment (1 hr) of SP600125 also strongly suppressed the inhibitory effect of melittin and bee venom on the LPS or SNP-induced NF-?
Regulation (effect) of LPS
19) Confidence 0.03 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0 Pain Relevance 0
We determined to assess the response of the sheep lung to repeated endobronchial administration of LPS.
Regulation (response) of LPS in lung
20) Confidence 0.02 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706618 Disease Relevance 0.45 Pain Relevance 0.21

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