INT9781

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Context Info
Confidence 0.31
First Reported 1983
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 64
Total Number 64
Disease Relevance 19.10
Pain Relevance 25.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
caudate nucleus 3
globus pallidus 3
putamen 3
brain 2
prefrontal 2
INSRR (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 74 100.00 Very High Very High Very High
antagonist 55 100.00 Very High Very High Very High
opioid receptor 52 100.00 Very High Very High Very High
dopamine receptor 3 100.00 Very High Very High Very High
Glutamate 3 100.00 Very High Very High Very High
Opioid 42 99.96 Very High Very High Very High
adenocard 31 99.90 Very High Very High Very High
agonist 60 99.88 Very High Very High Very High
Clonidine 7 99.80 Very High Very High Very High
nMDA receptor 5 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 201 99.98 Very High Very High Very High
Breast Cancer 155 99.62 Very High Very High Very High
Pressure Volume 2 Under Development 4 99.08 Very High Very High Very High
Cancer 391 98.48 Very High Very High Very High
Prostate Cancer 8 98.08 Very High Very High Very High
Dyskinesias 20 98.00 Very High Very High Very High
Pain 39 97.88 Very High Very High Very High
Epilepsy 6 97.76 Very High Very High Very High
Hyperalgesia 6 97.48 Very High Very High Very High
Neuropathic Pain 11 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, advanced grades of Huntington's disease showed an almost total loss of CB(1) receptors and the further depletion of D(1) receptors in the caudate nucleus, putamen and globus pallidus internus, and an increase in GABA(A) receptor binding in the globus pallidus internus.
) receptor Binding (binding) of in globus pallidus associated with gaba and disease
1) Confidence 0.31 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.59 Pain Relevance 0.86
Second, intermediate neuropathological grades (grades 1, 2) showed a further marked decrease of CB(1) receptor binding in the caudate nucleus and putamen; this was associated with a loss of D(1) receptors in the caudate nucleus and putamen and a loss of both CB(1) and D(1) receptors in the substantia nigra.
) receptor Binding (binding) of in putamen associated with substantia nigra
2) Confidence 0.31 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.55 Pain Relevance 0.60
Synthesis of numerous stereospecific analogues and conformational analyses of these peptides provided essential insights into the tertiary composition and microenvironment of the receptor "pocket" and the optimal interactions between receptor and ligand that trigger a biological response; new advances in the synthesis and receptor-binding properties of the deltorphins are discussed in detail.
receptor Binding (binding) of
3) Confidence 0.30 Published 1994 Journal Environ Health Perspect Section Abstract Doc Link PMC1567309 Disease Relevance 0.08 Pain Relevance 0.65
Synthesis of numerous stereospecific analogues and conformational analyses of these peptides provided essential insights into the tertiary composition and microenvironment of the receptor "pocket" and the optimal interactions between receptor and ligand that trigger a biological response; new advances in the synthesis and receptor-binding properties of the deltorphins are discussed in detail.
receptor Binding (interactions) of
4) Confidence 0.30 Published 1994 Journal Environ Health Perspect Section Abstract Doc Link PMC1567309 Disease Relevance 0.07 Pain Relevance 0.63
This study evaluates the inhibitory effects of twelve fluoroquinolones (ciprofloxacin, enoxacin, fleroxacin, gatifloxacin, levofloxacin, lomefloxacin, norfloxacin, ofloxacin, pazufloxacin, prulifloxacin, sparfloxacin, and tosufloxacin) alone or in the presence of an NSAID (4-biphenylacetic acid, diclofenac sodium, loxoprofen, lornoxicam or zaltoprofen) on the GABA(A) receptor binding of [(3)H]muscimol in an in vitro study using mice synaptic plasma membrane.
) receptor Binding (binding) of in plasma associated with gaba, cinod and diclofenac
5) Confidence 0.30 Published 2009 Journal Drug Metab. Pharmacokinet. Section Abstract Doc Link 19430173 Disease Relevance 0.43 Pain Relevance 0.38
However, a focal reduction of opioid receptor binding was observed and quantitated in the primary motor/sensory strip when compared to surrounding parietal cortex.
receptor Binding (binding) of in parietal cortex associated with opioid receptor
6) Confidence 0.27 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1650933 Disease Relevance 0.25 Pain Relevance 0.80
High levels of opioid receptor binding were seen in the cortical projections of the medial pain system in the cingulate and prefrontal cortex as has previously been observed in post-mortem studies.
receptor Binding (binding) of in medial associated with pain and opioid receptor
7) Confidence 0.27 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1650933 Disease Relevance 0.27 Pain Relevance 0.77
First, the very early stages of the disease (grade 0) were characterized by a major loss of cannabinoid CB(1), dopamine D(2) and adenosine A(2a) receptor binding in the caudate nucleus, putamen and globus pallidus externus and an increase in GABA(A) receptor binding in the globus pallidus externus.
) receptor Binding (binding) of in caudate nucleus associated with gaba, adenocard, dopamine, cannabinoid and disease
8) Confidence 0.24 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.57 Pain Relevance 0.54
First, the very early stages of the disease (grade 0) were characterized by a major loss of cannabinoid CB(1), dopamine D(2) and adenosine A(2a) receptor binding in the caudate nucleus, putamen and globus pallidus externus and an increase in GABA(A) receptor binding in the globus pallidus externus.
) receptor Binding (binding) of in caudate nucleus associated with gaba, adenocard, dopamine, cannabinoid and disease
9) Confidence 0.23 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.56 Pain Relevance 0.56
R(+)-8-Hydroxydipropylaminotetralin, on the other hand, bound the human receptor with the affinity higher than those for the primates and guinea pig receptors.
receptor Binding (bound) of
10) Confidence 0.21 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9406883 Disease Relevance 0.06 Pain Relevance 0.13
In vivo opioid receptor binding in the cortical projections of the medial (cingulate and prefrontal cortex) and lateral pain system (primary somatosensory cortex) in male volunteers has been quantitated using [11C]diprenorphine and positron emission tomography.
receptor Binding (binding) of in prefrontal associated with pain, primary somatosensory cortex, positron emission tomography and opioid receptor
11) Confidence 0.20 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1650933 Disease Relevance 0.25 Pain Relevance 0.54
In addition, we used statistical parametric mapping (SPM) and images reflecting the volume of distribution of [11C]diprenorphine to assess changes in cerebral receptor binding on a voxel-by-voxel basis.
receptor Binding (binding) of
12) Confidence 0.19 Published 1997 Journal Ann. Neurol. Section Abstract Doc Link 9392571 Disease Relevance 0.91 Pain Relevance 0.58
Alterations in opioid receptor binding in Parkinson's disease patients with levodopa-induced dyskinesias.
receptor Binding (binding) of associated with opioid receptor, disease and dyskinesias
13) Confidence 0.19 Published 1997 Journal Ann. Neurol. Section Title Doc Link 9392571 Disease Relevance 0.88 Pain Relevance 0.44
To determine whether the opioid system is involved in human dyskinetic PD, we measured in vivo opioid receptor binding in PD patients with and without levodopa-induced dyskinesias, using positron emission tomography (PET) and the opioid receptor ligand [11C]diprenorphine.
receptor Binding (binding) of associated with positron emission tomography, opioid receptor, disease, opioid and dyskinesias
14) Confidence 0.19 Published 1997 Journal Ann. Neurol. Section Abstract Doc Link 9392571 Disease Relevance 0.86 Pain Relevance 0.43
The SPM approach confirmed reduced availability in these areas and, in addition, showed decreased cingulate and increased prefrontal opioid receptor binding in the dyskinetic patients.
receptor Binding (binding) of in prefrontal associated with opioid receptor
15) Confidence 0.19 Published 1997 Journal Ann. Neurol. Section Abstract Doc Link 9392571 Disease Relevance 0.87 Pain Relevance 0.60
Although this receptor is identical to rodent 5-HT1B receptors in binding to 5-HT, it differs profoundly in binding to many drugs.
receptor Binding (binding) of
16) Confidence 0.16 Published 1992 Journal Nature Section Abstract Doc Link 1436092 Disease Relevance 0.39 Pain Relevance 0.12
Thus, drug-receptor interactions should not be extrapolated from animal to human species without verification.
receptor Binding (interactions) of
17) Confidence 0.16 Published 1992 Journal Nature Section Abstract Doc Link 1436092 Disease Relevance 0.26 Pain Relevance 0.08
However, the recent discovery of additional 5-HT3 subunits and the dawning realization that central and peripheral 5-HT3 receptor populations might comprise several subtypes characterized by distinct functional properties has emphasized the complexity of human 5-HT3 receptor signaling.
receptor Binding (complexity) of
18) Confidence 0.12 Published 2008 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 18597859 Disease Relevance 0.22 Pain Relevance 0.08
Second, intermediate neuropathological grades (grades 1, 2) showed a further marked decrease of CB(1) receptor binding in the caudate nucleus and putamen; this was associated with a loss of D(1) receptors in the caudate nucleus and putamen and a loss of both CB(1) and D(1) receptors in the substantia nigra.
) receptor Binding (binding) of in caudate nucleus associated with substantia nigra
19) Confidence 0.11 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.55 Pain Relevance 0.60
The inhibition of 3H-muscimol binding to the GABA(A) receptor is likely to be exclusively due to GABA present in the extract.
) receptor Binding (binding) of associated with gaba
20) Confidence 0.10 Published 2001 Journal Pharmacopsychiatry Section Abstract Doc Link 11518063 Disease Relevance 0 Pain Relevance 0.45

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