INT9782

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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 43
Total Number 44
Disease Relevance 12.08
Pain Relevance 19.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1B) cytoplasm (HTR1B) signal transducer activity (HTR1B)
Anatomy Link Frequency
brain 2
blood vessels 1
nerve 1
HeLa 1
superior 1
HTR1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Sumatriptan 140 100.00 Very High Very High Very High
agonist 74 100.00 Very High Very High Very High
Serotonin 45 100.00 Very High Very High Very High
addiction 6 100.00 Very High Very High Very High
alcohol 5 100.00 Very High Very High Very High
Triptan 86 99.90 Very High Very High Very High
Migraine 222 99.78 Very High Very High Very High
antagonist 40 99.26 Very High Very High Very High
ergotamine 8 98.64 Very High Very High Very High
Potency 20 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alcohol Addiction 15 100.00 Very High Very High Very High
Headache 217 99.78 Very High Very High Very High
Appetite Loss 5 99.52 Very High Very High Very High
Migraine Disorders 47 99.46 Very High Very High Very High
Movement Disorders 3 99.32 Very High Very High Very High
Cluster Headache 14 98.64 Very High Very High Very High
Menstral Migraine 28 98.30 Very High Very High Very High
Increased Venous Pressure Under Development 27 97.88 Very High Very High Very High
Pain 116 94.52 High High
INFLAMMATION 8 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Our results support an association between HTR1B and alcohol dependence.
HTR1B Binding (association) of
1) Confidence 0.47 Published 2002 Journal Biol. Psychiatry Section Body Doc Link 12022963 Disease Relevance 0.07 Pain Relevance 0
The clinical effective dose of ergotamine, beginning from the minimal dose of 1 mg, correlates well with its affinity for 5-HT1B and 5-HT1D receptors, and the rank order of clinical potency of ergotamine is superior to sumatriptan.
5-HT1B Binding (affinity) of in superior associated with sumatriptan, potency and ergotamine
2) Confidence 0.47 Published 1994 Journal Headache Section Abstract Doc Link 7928330 Disease Relevance 0.25 Pain Relevance 0.58
Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites.
5-HT1B Binding (interacts) of associated with sumatriptan
3) Confidence 0.47 Published 1989 Journal Eur. J. Pharmacol. Section Title Doc Link 2545459 Disease Relevance 0 Pain Relevance 0.57
The inhibitory potency of the drugs was significantly correlated with their affinity for 5-HTID receptors in human brain and for cloned human 5-HT1D alpha and 5-HT1D beta receptors, but not with their affinity for 5-HT1B, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT5B and 5-HT7 receptors.
5-HT1B Binding (affinity) of in brain associated with potency
4) Confidence 0.47 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692281 Disease Relevance 0 Pain Relevance 0.48
MDL 74,721 demonstrated nanomolar affinity for 5-HT1A (12.7 +/- 0.3 nM) and 5-HT1D (41.3 +/- 10.9 nM) but considerably lower affinity for 5-HT1B receptors (> 1000 nM).
5-HT1B Binding (affinity) of
5) Confidence 0.47 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384224 Disease Relevance 0.32 Pain Relevance 0.64
5-HT1B receptor binding in degenerative movement disorders.
5-HT1B Binding (binding) of associated with movement disorders
6) Confidence 0.47 Published 1998 Journal Brain Res. Section Title Doc Link 9593971 Disease Relevance 0.53 Pain Relevance 0.62
Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors.
5-HT1B Binding (binding) of
7) Confidence 0.47 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10193663 Disease Relevance 0.09 Pain Relevance 0.49
Site-directed mutagenesis was used to investigate the molecular interactions involved in ligand binding to the human 5-HT1B receptor.
5-HT1B Binding (binding) of
8) Confidence 0.47 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9671119 Disease Relevance 0 Pain Relevance 0.08
The efficacy of the antimigraine compound sumatriptan in migraine relief has been attributed to its interaction with 5-HT1B receptors in cerebral blood vessels causing cranial vasoconstriction, and/or on nerve endings of the trigeminovascular system in the dura mater inhibiting the inflammatory process by decreasing neuropeptide release.
5-HT1B Binding (interaction) of in blood vessels associated with cluster headache, sumatriptan, inflammation, migraine, increased venous pressure under development and neuropeptide release
9) Confidence 0.47 Published 1998 Journal Recept. Channels Section Abstract Doc Link 9826913 Disease Relevance 0.45 Pain Relevance 0.53
Nevertheless, PNU-142633 proved to be ineffective in the acute treatment of migraine, whilst LY344864 did show some efficacy when used in doses which interact with 5-HT1B receptors.
5-HT1B Binding (interact) of associated with migraine
10) Confidence 0.47 Published 2003 Journal Curr Vasc Pharmacol Section Abstract Doc Link 15320857 Disease Relevance 1.16 Pain Relevance 1.20
Anorexia is probably induced by interaction with 5-HT1B receptors in the rat; the human equivalent of this receptor is not known, but the 5-HT1D type is a likely candidate.
5-HT1B Binding (interaction) of associated with appetite loss
11) Confidence 0.47 Published 1989 Journal Br J Psychiatry Suppl Section Abstract Doc Link 2692639 Disease Relevance 0.46 Pain Relevance 0.18
Frovatriptan: A Review of Pharmacology, Pharmacokinetics and Clinical Potential in the Treatment of Menstrual Migraine

Frovatriptan is an orally active 5-hydroxytryptamine (5-HT) receptor agonist which binds with high affinity to 5-HT1B and 5-HT1D receptors.

5-HT1B Binding (binds) of associated with menstral migraine, migraine and agonist
12) Confidence 0.47 Published 2006 Journal Therapeutics and Clinical Risk Management Section Title Doc Link PMC1936266 Disease Relevance 0.85 Pain Relevance 0.52
PNU-142633 binds with a Ki of 6 nm at the human 5-HT1D receptor and a Ki of> 18 000 nm at the human 5-HT1B receptor.
5-HT1B Binding (binds) of
13) Confidence 0.47 Published 2002 Journal Cephalalgia Section Abstract Doc Link 12485205 Disease Relevance 0.20 Pain Relevance 0.54
Nevertheless, PNU-142633 proved to be ineffective in the acute treatment of migraine, whilst LY344864 did show some efficacy when used in doses which interact with 5-HT1B receptors.
5-HT1B Binding (interact) of associated with migraine
14) Confidence 0.47 Published 2002 Journal Proc. West. Pharmacol. Soc. Section Abstract Doc Link 12434581 Disease Relevance 1.24 Pain Relevance 1.20
The present data show that GR 43175 interacts preferentially as an agonist with 5-HT1B and 5-HT1D receptors.
5-HT1B Binding (interacts) of associated with agonist
15) Confidence 0.47 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2552330 Disease Relevance 0.06 Pain Relevance 0.34
These data indicate that sumatriptan interacts selectively with 5-HT1B and 5-HT1D sites and suggest that these interactions may be the basis of its apparent efficacy in the acute treatment of migraine.
5-HT1B Binding (interacts) of associated with sumatriptan and migraine
16) Confidence 0.47 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2545459 Disease Relevance 0.10 Pain Relevance 0.57
Because the linkage of antisocial alcoholism to the HTR1B gene was recently reported in two populations, it was of interest to identify genetic variants at the HTR1B locus and study their association with alcoholism in the Taiwanese Han population.
HTR1B Binding (association) of associated with alcohol addiction
17) Confidence 0.37 Published 2002 Journal Biol. Psychiatry Section Abstract Doc Link 12022963 Disease Relevance 0.70 Pain Relevance 0.42
METHODS: We sequenced DNA from Taiwanese Han to screen for genetic variation in the coding, promoter, and partial 3' untranslated regions of the HTR1B locus of 158 alcohol-dependent cases with withdrawal symptoms and 149 control subjects, who either never drank or drank only occasionally and in low quantities.
HTR1B Spec (partial) Binding (coding) of
18) Confidence 0.37 Published 2002 Journal Biol. Psychiatry Section Body Doc Link 12022963 Disease Relevance 0.09 Pain Relevance 0
In addition, the binding affinities for the 5-HT1B and 5-HT1D receptors were not correlated to headache recurrence.
5-HT1B Binding (affinities) of
19) Confidence 0.36 Published 2003 Journal Headache Section Body Doc Link 12656709 Disease Relevance 0.05 Pain Relevance 0
Isolated microvessels and capillaries consistently expressed messages for the h5-HT1B, h5-HT1D, 5-HT1F, 5-HT2A but not 5-HT7 receptors.
5-HT1B Binding (messages) of
20) Confidence 0.36 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10458598 Disease Relevance 0 Pain Relevance 0

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