INT97825

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.21
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dhodh) oxidoreductase activity (Dhodh)
Anatomy Link Frequency
adipocytes 1
Dhodh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Leflunomide 12 97.80 Very High Very High Very High
Neuritis 11 80.88 Quite High
diabetic neuropathy 1 54.12 Quite High
ischemia 1 50.24 Quite High
Inflammation 3 38.08 Quite Low
Demyelination 1 36.00 Quite Low
Peripheral nervous system 1 34.44 Quite Low
Sciatic nerve 1 32.72 Quite Low
anesthesia 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 6 98.12 Very High Very High Very High
Obesity 11 94.54 High High
Experimental Autoimmune Neuritis 11 82.80 Quite High
Infection 14 69.68 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 36 69.28 Quite High
Paraparesis 1 65.36 Quite High
Immunization 1 61.68 Quite High
Diabetic Neuropathy 1 54.12 Quite High
Hypoglycemia 1 51.16 Quite High
Cv Unclassified Under Development 1 50.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leflunomide is a new immunosuppressive drug whose active metabolite, A77 1726, impairs cellular nucleotide metabolism by inhibiting the dihydroorotate dehydrogenase (DHODH), a rate-limiting enzyme of de novo pyrimidine synthesis.
Negative_regulation (inhibiting) of DHODH associated with leflunomide
1) Confidence 0.57 Published 2001 Journal Brain Section Abstract Doc Link 11522581 Disease Relevance 0.49 Pain Relevance 0.58
Uridine has been able to abrogate the adverse effects of antiretroviral pyrimidine analogues in adipocytes [17], and the benefitial effects of uridine supplementation in cell culture models of stavudine toxicity seems to involve the recovery from nucleoside analogue-induced pyrimidine depletion, because uridine supplementation also prevented the effects of redoxal, a specific DHODH inhibitor which, in turn, exacerbated the mitochondrial toxicity of the stavudine [15].
Negative_regulation (inhibitor) of DHODH in adipocytes associated with toxicity and obesity
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981524 Disease Relevance 0.72 Pain Relevance 0.05

General Comments

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