INT97828

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2001
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lox) oxidoreductase activity (Lox) extracellular region (Lox)
proteinaceous extracellular matrix (Lox) nucleus (Lox)
Anatomy Link Frequency
inner ear 2
Lox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 1 100.00 Very High Very High Very High
Inflammation 1 100.00 Very High Very High Very High
Migraine 1 98.36 Very High Very High Very High
cINOD 1 97.54 Very High Very High Very High
qutenza 1 56.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 100.00 Very High Very High Very High
Apoptosis 1 99.16 Very High Very High Very High
Headache 1 98.36 Very High Very High Very High
Cancer 3 98.28 Very High Very High Very High
Disease 1 97.84 Very High Very High Very High
Tinnitus 1 97.08 Very High Very High Very High
Colon Cancer 1 96.20 Very High Very High Very High
Hypersensitivity 1 93.24 High High
Ganglion Cysts 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, these data suggest that LOX activation during inflammatory processes or during cyclo-oxygenase inhibition (e.g. by aspirin) is a potential intrinsic source of VR1 activation in inner ear ganglia.
Positive_regulation (activation) of Positive_regulation (activation) of LOX in inner ear associated with aspirin and inflammation
1) Confidence 0.43 Published 2003 Journal Hear. Res. Section Abstract Doc Link 12527134 Disease Relevance 0.69 Pain Relevance 0.25
Recent studies indicate that 15-LOX-1 is down-regulated in colorectal cancer cells and that the ability of nonsteroidal anti-inflammatory drugs, a class of clinically active cancer chemopreventive agents, to induce apoptosis and growth inhibition in these cells was dependent on the induction of 15-LOX-1 and its metabolic product 13-S-hydroxyoctadecadienoic acid.
Positive_regulation (dependent) of Positive_regulation (induction) of LOX associated with inflammation, cancer, colon cancer, cinod and apoptosis
2) Confidence 0.27 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11522616 Disease Relevance 0.53 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox