INT97829

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 1.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pdx1) cytosol (Pdx1) nucleus (Pdx1)
DNA binding (Pdx1) transcription factor binding (Pdx1) cytoplasm (Pdx1)
Anatomy Link Frequency
precursor cells 1
immune cells 1
pancreas 1
proximal 1
ovary 1
Pdx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 13 50.00 Quite Low
Inflammation 1 50.00 Quite Low
anesthesia 5 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intrauterine Growth Retardation 1 99.14 Very High Very High Very High
Cytomegalovirus Infection 96 98.58 Very High Very High Very High
Cancer 1 95.56 Very High Very High Very High
Breast Cancer 1 91.80 High High
Infection 37 90.80 High High
Diabetes Mellitus 10 86.72 High High
Obesity 2 61.08 Quite High
Pancreatitis 14 57.04 Quite High
Hypertension 19 53.96 Quite High
Nicotine Addiction 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animals with fibrotic alterations showed an induction of pancreatic pro-collagen 1 gene expression, and the infiltration of immune cells was accompanied by the expression of the inflammatory mediators MIP-1alpha, IL-1beta, and TGF-beta in 33% (4/12) of the animals.
Gene_expression (expression) of pancreatic pro-collagen 1 gene in immune cells
1) Confidence 0.32 Published 2006 Journal Am. J. Gastroenterol. Section Body Doc Link 16405548 Disease Relevance 0 Pain Relevance 0
In ACP, ductal islet precursor cells were associated with IPF-1 hyperexpression, suggesting a critical role of IPF-1 on islet cell differentiation and eventual beta-cell restoration.


Gene_expression (hyperexpression) of IPF-1 in precursor cells
2) Confidence 0.32 Published 2001 Journal Diabetes Care Section Body Doc Link 11522716 Disease Relevance 0 Pain Relevance 0
Insulin promoter factor-1 (IPF-1) was hyperexpressed in insulin-containing ductal cells.
Gene_expression (hyperexpressed) of Insulin promoter factor-1
3) Confidence 0.32 Published 2001 Journal Diabetes Care Section Body Doc Link 11522716 Disease Relevance 0.06 Pain Relevance 0
Insulin promoter factor-1 (IPF-1) was hyperexpressed in insulin-containing ductal cells.
Gene_expression (hyperexpressed) of IPF-1
4) Confidence 0.32 Published 2001 Journal Diabetes Care Section Body Doc Link 11522716 Disease Relevance 0.06 Pain Relevance 0
However, recently, it was reported that intrauterine growth retardation is associated with progressive epigenetic silencing of Pdx1, a pancreatic and duodenal homeobox 1 TF that regulates pancreas development and ?
Gene_expression (silencing) of Pdx1 in pancreas associated with intrauterine growth retardation
5) Confidence 0.25 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0.24 Pain Relevance 0
The synthesis of Ldha isoenzyme was found to increase significantly in the uterus of immature mice, and expression from the mouse lactate dehydrogenase-A promoter fused to the cat gene in Chinese hamster ovary cells was also induced by E2 and DES [48].
Gene_expression (expression) of promoter in ovary
6) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.31 Pain Relevance 0
To validate the suitability of our modified pFTMGW vector for promoter screening in vitro, we measured eGFP expression from a proximal promoter fragment of a glial specific gene cloned into the MCS of pFTMGW.
Gene_expression (expression) of promoter in proximal
7) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765473 Disease Relevance 0 Pain Relevance 0
By flow cytometry analysis (Figure 2A), the Vim409 plasmid drove eGFP expression as well as the ubiquitin-C promoter in the parent vector (pFUGW).
Gene_expression (expression) of promoter
8) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765473 Disease Relevance 0 Pain Relevance 0
Similarly, by quantitative RT-PCR analysis, transfection with the Vim409 promoter resulted in equal or slightly higher levels of expression when compared to pFUGW (Figure 2B).
Gene_expression (transfection) of promoter
9) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765473 Disease Relevance 0 Pain Relevance 0
Transfection data, quantitative RT-PCR, and flow cytometry show that around 85% of expression from the CMV promoter was blocked by the TB element, allowing direct evaluation of expression from the Vim409 candidate promoter cloned into the MCS.
Gene_expression (expression) of promoter associated with cytomegalovirus infection
10) Confidence 0.01 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2765473 Disease Relevance 0.48 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox