INT9783

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Context Info
Confidence 0.50
First Reported 1984
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 81
Total Number 84
Disease Relevance 32.99
Pain Relevance 15.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
glands 9
ovary 4
annulus 3
stroma 2
alveolar macrophages 2
INSRR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 111 100.00 Very High Very High Very High
Serotonin 47 100.00 Very High Very High Very High
opioid receptor 16 100.00 Very High Very High Very High
chemokine 7 100.00 Very High Very High Very High
Inflammatory marker 2 100.00 Very High Very High Very High
Inflammation 71 99.92 Very High Very High Very High
Dismenorea 55 99.88 Very High Very High Very High
opiate 10 99.72 Very High Very High Very High
endometriosis 14 99.54 Very High Very High Very High
bradykinin 11 98.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 82 100.00 Very High Very High Very High
Adhesions 29 100.00 Very High Very High Very High
Dysmenorrhea 55 99.88 Very High Very High Very High
Glioblastoma 92 99.84 Very High Very High Very High
Malignant Neoplastic Disease 71 99.84 Very High Very High Very High
Dengue Hemorrhagic Fever 134 99.68 Very High Very High Very High
Targeted Disruption 21 99.64 Very High Very High Very High
Motor Neuron Diseases 4 99.62 Very High Very High Very High
Endometriosis (extended) 18 99.54 Very High Very High Very High
Cancer 827 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients suffering from retinal receptor disturbances the flash electroretinogram (FERG), which is probably an expression of receptor activity, was greatly impaired, whereas PERGs were either normal or less impaired than FERGs.
Gene_expression (expression) of receptor
1) Confidence 0.50 Published 1984 Journal Boll. Soc. Ital. Biol. Sper. Section Abstract Doc Link 6466462 Disease Relevance 0.67 Pain Relevance 0.16
Hence, the IRR was highest in the shortest employees (IRR 9.8, 95% CI 3.1–30.9).
Gene_expression (highest) of IRR
2) Confidence 0.42 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1989755 Disease Relevance 0.66 Pain Relevance 0
Hence, the IRR was highest in the shortest employees (IRR 9.8, 95% CI 3.1–30.9).
Gene_expression (highest) of IRR
3) Confidence 0.42 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1989755 Disease Relevance 0.64 Pain Relevance 0
In summary, the present results demonstrate that invading endometrial glands in adenomyosis selectively express more hCG/LH receptor mRNA and immunoreactive receptor protein than noninvading glands.
Gene_expression (express) of receptor in glands associated with dismenorea
4) Confidence 0.29 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7680356 Disease Relevance 0.60 Pain Relevance 0.41
Our laboratory recently demonstrated that normal human endometrial glands and stroma express the hCG/LH receptor gene.
Gene_expression (express) of receptor in glands
5) Confidence 0.29 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7680356 Disease Relevance 0.44 Pain Relevance 0.35
The higher receptor expression in invading glands is specific because the invading and noninvading stroma showed similar receptor expression, invading and noninvading glands showed similar expression of cadherin, a cell adhesion receptor, and ectopic and eutopic endometrial glands from endometriosis showed similar hCG/LH receptor expression.
Gene_expression (expression) of receptor in glands associated with endometriosis and adhesions
6) Confidence 0.29 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7680356 Disease Relevance 0.63 Pain Relevance 0.42
But a similar receptor could not be detected in human brain, suggesting the absence in man of a receptor with equivalent function.
Neg (not) Gene_expression (detected) of receptor in brain
7) Confidence 0.28 Published 1992 Journal Nature Section Abstract Doc Link 1436092 Disease Relevance 0.46 Pain Relevance 0.14
The 5-hydroxytryptamine 3 (5-HT3) receptor is expressed widely in the central and peripheral nervous systems, where it mediates or modulates a wide range of physiological processes.
Gene_expression (expressed) of receptor in peripheral nervous systems
8) Confidence 0.25 Published 2008 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 18597859 Disease Relevance 0.25 Pain Relevance 0.08
The higher receptor expression in invading glands is specific because the invading and noninvading stroma showed similar receptor expression, invading and noninvading glands showed similar expression of cadherin, a cell adhesion receptor, and ectopic and eutopic endometrial glands from endometriosis showed similar hCG/LH receptor expression.
Gene_expression (expression) of receptor in glands associated with endometriosis and adhesions
9) Confidence 0.22 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7680356 Disease Relevance 0.64 Pain Relevance 0.43
The higher receptor expression in invading glands is specific because the invading and noninvading stroma showed similar receptor expression, invading and noninvading glands showed similar expression of cadherin, a cell adhesion receptor, and ectopic and eutopic endometrial glands from endometriosis showed similar hCG/LH receptor expression.
Gene_expression (expression) of receptor in glands associated with endometriosis and adhesions
10) Confidence 0.22 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7680356 Disease Relevance 0.63 Pain Relevance 0.42
In summary, the present results demonstrate that invading endometrial glands in adenomyosis selectively express more hCG/LH receptor mRNA and immunoreactive receptor protein than noninvading glands.
Gene_expression (express) of receptor in glands associated with dismenorea
11) Confidence 0.22 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7680356 Disease Relevance 0.60 Pain Relevance 0.41
The higher receptor expression in invading glands is specific because the invading and noninvading stroma showed similar receptor expression, invading and noninvading glands showed similar expression of cadherin, a cell adhesion receptor, and ectopic and eutopic endometrial glands from endometriosis showed similar hCG/LH receptor expression.
Gene_expression (expression) of receptor in glands associated with endometriosis and adhesions
12) Confidence 0.22 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7680356 Disease Relevance 0.63 Pain Relevance 0.43
Whether this increased receptor expression is the cause or a consequence of myometrial invasion of glands in unknown.
Spec (Whether) Gene_expression (expression) of receptor in glands
13) Confidence 0.22 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7680356 Disease Relevance 0.47 Pain Relevance 0.34
This prompted us to investigate whether invading glands and stroma in adenomyosis also express this receptor gene.
Gene_expression (express) of receptor in stroma associated with dismenorea
14) Confidence 0.22 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7680356 Disease Relevance 0.45 Pain Relevance 0.36
The receptor is targeted by drugs administered for nausea and/or emesis and irritable bowel syndrome and has been proposed as a potential drug target in various psychiatric disorders.
Gene_expression (targeted) of receptor in bowel associated with spastic colon and vomiting
15) Confidence 0.21 Published 2008 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 18597859 Disease Relevance 0.30 Pain Relevance 0.10
Pharmacological analysis showed that sumatriptan was less potent than 5-HT in inducing contraction in freshly isolated human cerebral arteries and revealed an overall pharmacological profile positively and significantly correlated with that published for the 5-HT1D alpha (r = 0.746, p = 0.021) and 5-HT1D beta (r = 0.942, p = 0.0001) cloned human receptor subtypes.
Gene_expression (published) of receptor associated with sumatriptan
16) Confidence 0.17 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8394988 Disease Relevance 0.21 Pain Relevance 0.58
Expression of mRNA for the serotonin 5-hydroxytryptamine1D beta receptor subtype in human and bovine cerebral arteries.
Gene_expression (Expression) of receptor associated with serotonin
17) Confidence 0.15 Published 1993 Journal Mol. Pharmacol. Section Title Doc Link 8394988 Disease Relevance 0.18 Pain Relevance 0.50
Recombinant human 5-HT1D alpha and 5-HT1D beta receptor subtypes were stably expressed in NIH-3T3 fibroblasts (1D alpha cell line) and Y-1 adrenocortical tumor cells (1D beta cell line), respectively, for pharmacological evaluations of serotonergic compounds to inhibit forskolin-stimulated cAMP accumulation (FSCA). [3H]LSD saturation studies indicated that 5-HT1D receptor expression levels were slightly higher in the 1D beta cell line (Bmax = 1334 +/- 134 fmol/mg protein) than in the 1D alpha cell line (Bmax = 900 +/- 218 fmol/mg protein). 5-HT inhibited FSCA with similar potencies (EC50 approximately 2 nM) in both assay systems.
Gene_expression (expressed) of receptor in beta cell associated with cancer
18) Confidence 0.11 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8878051 Disease Relevance 0.10 Pain Relevance 0.03
Recombinant human 5-HT1D alpha and 5-HT1D beta receptor subtypes were stably expressed in NIH-3T3 fibroblasts (1D alpha cell line) and Y-1 adrenocortical tumor cells (1D beta cell line), respectively, for pharmacological evaluations of serotonergic compounds to inhibit forskolin-stimulated cAMP accumulation (FSCA). [3H]LSD saturation studies indicated that 5-HT1D receptor expression levels were slightly higher in the 1D beta cell line (Bmax = 1334 +/- 134 fmol/mg protein) than in the 1D alpha cell line (Bmax = 900 +/- 218 fmol/mg protein). 5-HT inhibited FSCA with similar potencies (EC50 approximately 2 nM) in both assay systems.
Gene_expression (expression) of receptor in Y-1 associated with cancer
19) Confidence 0.11 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8878051 Disease Relevance 0.10 Pain Relevance 0.10
Although the potencies (EC50 values) of compounds matched their respective affinity constants (Ki values) for the closely-related 5-HT1D subtypes, differences in intrinsic activities were observed for a few compounds between the two 5-HT1D receptor expression systems.
Gene_expression (expression) of receptor
20) Confidence 0.11 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8878051 Disease Relevance 0 Pain Relevance 0.17

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