INT97847

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 5.41
Pain Relevance 4.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptafr) plasma membrane (Ptafr) nucleus (Ptafr)
signal transducer activity (Ptafr)
Anatomy Link Frequency
nerve 1
spinal cord 1
Platelet 1
dorsal horn 1
Ptafr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 3 100.00 Very High Very High Very High
antagonist 27 99.96 Very High Very High Very High
Brush evoked pain 144 99.88 Very High Very High Very High
Adelta 1 99.72 Very High Very High Very High
Pain 25 99.58 Very High Very High Very High
Neuropathic pain 36 98.16 Very High Very High Very High
Substantia gelatinosa neuron 1 97.68 Very High Very High Very High
dorsal root ganglion 286 97.56 Very High Very High Very High
Spinal cord 21 96.68 Very High Very High Very High
qutenza 9 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 198 99.88 Very High Very High Very High
Pain 31 99.58 Very High Very High Very High
Nervous System Injury 174 99.00 Very High Very High Very High
Syndrome 4 99.00 Very High Very High Very High
Ganglion Cysts 289 97.56 Very High Very High Very High
Cv General 3 Under Development 4 92.60 High High
Low Back Pain 1 88.60 High High
Hyperalgesia 9 88.40 High High
Neurodegenerative Disease 3 83.84 Quite High
Cv Unclassified Under Development 4 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By contrast, the PAFR agonist did not affect C- or Adelta-evoked excitatory post-synaptic currents in substantia gelatinosa neurons in the dorsal horn.
Neg (not) Regulation (affect) of PAFR in dorsal horn associated with adelta, dorsal horn, agonist and substantia gelatinosa neuron
1) Confidence 0.43 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17662046 Disease Relevance 1.13 Pain Relevance 1.32
S1), suggesting that the anti-allodynic effect of the PAFR antagonist may predominantly involve PAFRs expressed in the DRG rather than in the spinal cord.
Regulation (effect) of PAFR in spinal cord associated with dorsal root ganglion, antagonist and spinal cord
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.34 Pain Relevance 1.20
Effects of PAFR and LPAR antagonists on nerve injury-induced tactile allodynia
Regulation (Effects) of PAFR in nerve associated with brush evoked pain, nervous system injury and antagonist
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 0.98 Pain Relevance 0.72
Importantly, basal pain sensitivity was not altered in pafr?
Neg (not) Regulation (altered) of pafr associated with pain
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.28 Pain Relevance 0.96
We analyzed 20 variables in the 1,915 patients enrolled in the Platelet Receptor Inhibition for Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms trial.
Regulation (enrolled) of Platelet Receptor in Platelet associated with syndrome
5) Confidence 0.03 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11524055 Disease Relevance 0.68 Pain Relevance 0.44

General Comments

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