INT97847

Context Info Confidence 0.43 First Reported 2001 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 3 Total Number 5 Disease Relevance 5.41 Pain Relevance 4.64

signal transduction (Ptafr) plasma membrane (Ptafr) nucleus (Ptafr) signal transducer activity (Ptafr)

Anatomy Link Frequency nerve 1 spinal cord 1 Platelet 1 dorsal horn 1 Ptafr (Mus musculus)

Pain Link Frequency Relevance Heat agonist 3 100.00 antagonist 27 99.96 Brush evoked pain 144 99.88 Adelta 1 99.72 Pain 25 99.58 Neuropathic pain 36 98.16 Substantia gelatinosa neuron 1 97.68 dorsal root ganglion 286 97.56 Spinal cord 21 96.68 qutenza 9 96.60

Disease Link Frequency Relevance Heat Neuropathic Pain 198 99.88 Pain 31 99.58 Nervous System Injury 174 99.00 Syndrome 4 99.00 Ganglion Cysts 289 97.56 Cv General 3 Under Development 4 92.60 Low Back Pain 1 88.60 Hyperalgesia 9 88.40 Neurodegenerative Disease 3 83.84 Cv Unclassified Under Development 4 80.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

By contrast, the PAFR agonist did not affect C- or Adelta-evoked excitatory post-synaptic currents in substantia gelatinosa neurons in the dorsal horn.

Neg (not) Regulation (affect) of PAFR in dorsal horn associated with adelta, dorsal horn, agonist and substantia gelatinosa neuron

1) Confidence 0.43 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17662046 Disease Relevance 1.13 Pain Relevance 1.32

S1), suggesting that the anti-allodynic effect of the PAFR antagonist may predominantly involve PAFRs expressed in the DRG rather than in the spinal cord.

Regulation (effect) of PAFR in spinal cord associated with dorsal root ganglion, antagonist and spinal cord

2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.34 Pain Relevance 1.20

Effects of PAFR and LPAR antagonists on nerve injury-induced tactile allodynia

Regulation (Effects) of PAFR in nerve associated with brush evoked pain, nervous system injury and antagonist

3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 0.98 Pain Relevance 0.72

Importantly, basal pain sensitivity was not altered in pafr?

Neg (not) Regulation (altered) of pafr associated with pain

4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.28 Pain Relevance 0.96

We analyzed 20 variables in the 1,915 patients enrolled in the Platelet Receptor Inhibition for Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms trial.

Regulation (enrolled) of Platelet Receptor in Platelet associated with syndrome

5) Confidence 0.03 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11524055 Disease Relevance 0.68 Pain Relevance 0.44

General Comments

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