INT97848

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 7.66
Pain Relevance 13.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
primary sensory neurons 4
sensory neurons 2
brain 2
nociceptors 2
kidney 2
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 345 100.00 Very High Very High Very High
Calcitonin gene-related peptide 105 100.00 Very High Very High Very High
Inflammation 88 100.00 Very High Very High Very High
agonist 56 100.00 Very High Very High Very High
bradykinin 32 100.00 Very High Very High Very High
Sciatic nerve 10 100.00 Very High Very High Very High
gABA 6 100.00 Very High Very High Very High
substance P 26 99.96 Very High Very High Very High
chemokine 4 99.82 Very High Very High Very High
Dorsal horn 21 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bone Cancer 89 100.00 Very High Very High Very High
INFLAMMATION 79 100.00 Very High Very High Very High
Pancreatitis 5 99.98 Very High Very High Very High
Ganglion Cysts 265 98.72 Very High Very High Very High
Nociception 57 98.16 Very High Very High Very High
Hyperalgesia 55 98.00 Very High Very High Very High
Targeted Disruption 8 94.56 High High
Inflammatory Pain 12 93.04 High High
Pain 100 92.36 High High
Hypersensitivity 24 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The vanilloid receptor-1 (VR1) is activated by capsaicin, heat and protons and is localized on primary sensory neurons.
Positive_regulation (activated) of Localization (localized) of vanilloid receptor-1 in primary sensory neurons associated with qutenza
1) Confidence 0.50 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11524156 Disease Relevance 0.09 Pain Relevance 0.38
The vanilloid receptor-1 (VR1) is activated by capsaicin, heat and protons and is localized on primary sensory neurons.
Positive_regulation (activated) of Localization (localized) of VR1 in primary sensory neurons associated with qutenza
2) Confidence 0.50 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11524156 Disease Relevance 0.09 Pain Relevance 0.38
The main part of the capsaicin-releasable Ca(2+) store was insensitive to thapsigargin, a selective endoplasmic reticulum Ca(2+)-ATPase inhibitor, suggesting that VR1 might be predominantly localized to a thapsigargin-insensitive endoplasmic reticulum Ca(2+) store.
Spec (suggesting) Positive_regulation (suggesting) of Localization (localized) of VR1 in reticulum associated with qutenza
3) Confidence 0.50 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12454015 Disease Relevance 0.30 Pain Relevance 0.48
P2Y2 receptors mediate ATP-induced resensitization of TRPV1 expressed by kidney projecting sensory neurons.
Positive_regulation (induced) of Localization (resensitization) of TRPV1 in kidney associated with qutenza
4) Confidence 0.50 Published 2010 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 20335377 Disease Relevance 0 Pain Relevance 0.48
In contrast, TRPV1 sensitization caused by bradykinin, IL-1beta, and artemin was insensitive to inhibition of SNARE-dependent vesicular fusion and was not due to an increase in TRPV1 surface expression.
Positive_regulation (increase) of Localization (sensitization) of TRPV1 associated with bradykinin
5) Confidence 0.50 Published 2009 Journal FASEB J. Section Abstract Doc Link 19584302 Disease Relevance 0.41 Pain Relevance 0.68
Pro-inflammatory agents such as nerve growth factor (NGF), ATP, bradykinins, serotonin, histamine, proteases and chemokines lead to TRPV1 sensitization through phospholipase C activation.
Positive_regulation (activation) of Localization (sensitization) of TRPV1 in nerve associated with chemokine, nerve growth factor, inflammation and serotonin
6) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.62 Pain Relevance 0.92
Immunohistochemical studies show that TRPV1 in DRG neuronal cell bodies and peripheral terminals are preserved, suggesting that sensory efferent functions such as TRPV1-mediated CGRP and SP release at the peripheral nerve terminals will not be affected.
Positive_regulation (mediated) of Localization (release) of TRPV1 in peripheral nerve associated with dorsal root ganglion
7) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.71 Pain Relevance 0.61
The findings that co-localization of TRPV1 and LPA1 receptor EDG-2 and bone cancer induced an increase in LPA1 receptor expression in DRG [40] provide further support for these phenomena.
Positive_regulation (increase) of Localization (localization) of TRPV1 associated with dorsal root ganglion and bone cancer
8) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 1.97 Pain Relevance 1.43
In conclusion, gingerols and shogaols activated TRPV1 and increased adrenaline secretion.
Positive_regulation (activated) of Localization (secretion) of TRPV1
9) Confidence 0.47 Published 2006 Journal Nutr Neurosci Section Abstract Doc Link 17176640 Disease Relevance 0.08 Pain Relevance 0.18
Proton-induced calcitonin gene-related peptide release from rat sciatic nerve axons, in vitro, involving TRPV1.
Positive_regulation (induced) of Localization (release) of TRPV1 in sciatic nerve associated with qutenza, sciatic nerve and calcitonin gene-related peptide
10) Confidence 0.45 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 12925006 Disease Relevance 0 Pain Relevance 0.71
In addition to these morphological changes, increased cAMP levels in oxaliplatin-treated neurons (Figure 4) correlated with functional effects of TRPV1 and TRPA1 sensitization, not observed for TRPM8, after acute and chronic treatment with oxaliplatin (Figure 6).
Positive_regulation (effects) of Localization (sensitization) of TRPV1 in neurons
11) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC3003244 Disease Relevance 0.14 Pain Relevance 0.14
In conclusion, the TRPV1 system, which is activated by capsaicin and anandamide, is preferentially coupled with non-NMDA and GABA(A) receptor systems in the brain and stimulates gastric acid secretion in rats.
Positive_regulation (activated) of Localization (secretion) of TRPV1 in brain associated with gaba and qutenza
12) Confidence 0.44 Published 2005 Journal Brain Res. Section Abstract Doc Link 15781048 Disease Relevance 0 Pain Relevance 0.98
Two complementary mechanisms of TRPV1 inflammatory sensitization have been proposed, namely a decrease of its activation threshold and an increment of its surface expression in nociceptors.
Positive_regulation (increment) of Localization (sensitization) of TRPV1 in nociceptors associated with inflammation and nociceptor
13) Confidence 0.44 Published 2009 Journal FASEB J. Section Abstract Doc Link 19584302 Disease Relevance 0.54 Pain Relevance 0.57
Thus necrotizing pancreatitis activates TRPV1 on pancreatic sensory nerves to release SP and CGRP in the dorsal horn, resulting in nociception.
Positive_regulation (activates) of Localization (release) of TRPV1 in sensory nerves associated with nociception, pancreatitis, dorsal horn and substance p
14) Confidence 0.43 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16399878 Disease Relevance 0.76 Pain Relevance 1.03
, but not PKA or Rho, mediates LPA-induced potentiation of TRPV1 currents
Positive_regulation (induced) of Localization (potentiation) of TRPV1
15) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.81 Pain Relevance 0.89
Citral initially increased the agonist-evoked responses of TRPV1, TRPV2, and TRPV3 (Fig. 2A, B).
Positive_regulation (increased) of Localization (responses) of TRPV1 associated with agonist
16) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.55
Our observation is also in line with the finding that S800 is crucially involved in PMA-mediated sensitization of TRPV1 via PKC-?
Positive_regulation (mediated) of Localization (sensitization) of TRPV1
17) Confidence 0.40 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.16
Chronic treatment with NGF and GDNF significantly and concentration-dependently increased 100 nM capsaicin (CAP)-evoked calcitonin gene-related peptide (CGRP) release, reaching approximately 300% at the highest concentration tested (100 ng/ml).
Positive_regulation (increased) of Localization (release) of capsaicin associated with qutenza, nerve growth factor and calcitonin gene-related peptide
18) Confidence 0.38 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC548274 Disease Relevance 0.45 Pain Relevance 1.04
These results suggested that both capsaicin and acid increase gastric HCO3(-) secretion via a common pathway, involving PG and NO as well as capsaicin-sensitive afferent neurons, yet their responses differ concerning TRPV1 or prostanoid receptor dependence.
Positive_regulation (increase) of Localization (secretion) of TRPV1 in afferent neurons associated with addiction and qutenza
19) Confidence 0.36 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15985616 Disease Relevance 0 Pain Relevance 0.92
Other evidence suggests that application of ATP to capsaicin-sensitive sensory neurons increases TRPV1-dependent SP release [37].
Positive_regulation (increases) of Localization (release) of TRPV1 in sensory neurons associated with qutenza
20) Confidence 0.36 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2104004 Disease Relevance 0.70 Pain Relevance 0.84

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