INT9785

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Context Info
Confidence 0.43
First Reported 1982
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 1.88
Pain Relevance 7.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
neurons 4
gonadal 2
PGE2 2
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 43 100.00 Very High Very High Very High
Opioid 7 99.98 Very High Very High Very High
tetrodotoxin 6 99.98 Very High Very High Very High
antagonist 17 99.86 Very High Very High Very High
Morphine 17 99.76 Very High Very High Very High
cocaine 5 99.64 Very High Very High Very High
monoamine 4 99.62 Very High Very High Very High
Acupuncture 56 99.08 Very High Very High Very High
Nicotine 9 98.98 Very High Very High Very High
agonist 5 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 4 99.98 Very High Very High Very High
Rheumatic Heart Disease 13 99.84 Very High Very High Very High
Polycystic Ovary Syndrome 62 87.92 High High
Aging 3 79.92 Quite High
Infection 1 75.00 Quite High
Decapitation 1 67.88 Quite High
Prostate Cancer 9 57.76 Quite High
Growth Problems 1 57.04 Quite High
Mitral Valve Stenosis 1 34.64 Quite Low
Aortic Valve Insufficiency 1 33.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results that cocaine and tetrodotoxin attenuated phorbol ester stimulation of GnRH, presumably through inhibition of Na+ influx, suggest a direct biochemical mechanism for cocaine disruption of hypothalamic GnRH secretion and, consequently, cyclic reproductive function.
Negative_regulation (attenuated) of Positive_regulation (stimulation) of GnRH associated with tetrodotoxin and cocaine
1) Confidence 0.43 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1475011 Disease Relevance 0 Pain Relevance 0.45
A blockade of alpha-adrenergic receptor with phenoxybenzamine significantly suppressed the naloxone-stimulated GnRH release, whereas treatment with propranolol, a beta-adrenergic receptor blocker, failed to alter GnRH release.
Negative_regulation (suppressed) of Positive_regulation (naloxone-stimulated) of GnRH associated with narcan
2) Confidence 0.43 Published 1991 Journal Acta Endocrinol. Section Abstract Doc Link 1665001 Disease Relevance 0.07 Pain Relevance 0.49
Substituting Cl- in the incubation buffer with the non-permeant anion, isethionate, did not alter PGE2 stimulation of LHRH release, but it drastically inhibited Cu/PGE2 stimulation of LHRH release, indicating that this process requires a permeant monovalent anion.
Negative_regulation (inhibited) of Positive_regulation (stimulation) of LHRH
3) Confidence 0.42 Published 1988 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 3286321 Disease Relevance 0 Pain Relevance 0.15
Acute immobilization stress suppresses naloxone- and N-methyl-d-aspartate (NMDA)-induced, but not gonadotropin-releasing hormone (GnRH)-induced, luteinizing hormone (LH) release in ovariectomized oestrogen-primed rats.
Negative_regulation (suppresses) of Neg (not) Positive_regulation (-induced) of GnRH associated with stress and narcan
4) Confidence 0.41 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716406 Disease Relevance 0.25 Pain Relevance 0.20
However, when rats were pretreated with morphine (-15 min) and NE was infused i.c.v. at 0 time, significant amplification of LH release occurred but, unexpectedly, morphine completely blocked NE-induced increases in LHRH mRNA levels in all of the neurons we examined.
Negative_regulation (blocked) of Spec (examined) Positive_regulation (increases) of LHRH mRNA in neurons associated with morphine
5) Confidence 0.41 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255183 Disease Relevance 0 Pain Relevance 0.54
Morphine amplifies norepinephrine (NE)-induced LH release but blocks NE-stimulated increases in LHRH mRNA levels: comparison of responses obtained in ovariectomized, estrogen-treated normal and androgen-sterilized rats.
Negative_regulation (blocks) of Positive_regulation (increases) of LHRH mRNA associated with morphine
6) Confidence 0.41 Published 1993 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8255183 Disease Relevance 0 Pain Relevance 0.20
Opioid inhibition of adrenergic and dopaminergic but not serotonergic stimulation of luteinizing hormone releasing hormone release from immortalized hypothalamic neurons.
Negative_regulation (inhibition) of Positive_regulation (stimulation) of luteinizing hormone in neurons associated with opioid
7) Confidence 0.40 Published 1994 Journal Mol. Cell. Neurosci. Section Title Doc Link 7704439 Disease Relevance 0 Pain Relevance 0.75
Leuprorelin (leuprolide acetate) is a synthetic analogue of gonadotrophin-releasing hormone (GnRH) [luteinising hormone-releasing hormone (LHRH)] which initially stimulates luteinising hormone (LH) and hence testicular androgen release; continuous administration then results in profound suppression of these hormones.
Negative_regulation (analogue) of Positive_regulation ([luteinising) of LHRH
8) Confidence 0.39 Published 1991 Journal Drugs Aging Section Abstract Doc Link 1794035 Disease Relevance 0.06 Pain Relevance 0
Leuprorelin (leuprolide acetate) is a synthetic analogue of gonadotrophin-releasing hormone (GnRH) [luteinising hormone-releasing hormone (LHRH)] which initially stimulates luteinising hormone (LH) and hence testicular androgen release; continuous administration then results in profound suppression of these hormones.
Negative_regulation (analogue) of Positive_regulation ([luteinising) of GnRH
9) Confidence 0.39 Published 1991 Journal Drugs Aging Section Abstract Doc Link 1794035 Disease Relevance 0.06 Pain Relevance 0
Leuprorelin (leuprolide acetate) is a synthetic analogue of gonadotrophin-releasing hormone (GnRH) [luteinising hormone-releasing hormone (LHRH)] which initially stimulates luteinising hormone (LH) and hence testicular androgen release; continuous administration then results in profound suppression of these hormones.
Negative_regulation (analogue) of Positive_regulation ([luteinising) of luteinising hormone
10) Confidence 0.39 Published 1991 Journal Drugs Aging Section Abstract Doc Link 1794035 Disease Relevance 0.06 Pain Relevance 0
Antagonist of gonadotropin-releasing hormone blocks naloxone-induced elevations in serum luteinizing hormone.
Negative_regulation (blocks) of Positive_regulation (elevations) of hormone associated with antagonist and narcan
11) Confidence 0.37 Published 1982 Journal Neuroendocrinology Section Title Doc Link 6755289 Disease Relevance 0 Pain Relevance 0.87
Low-frequency EA restored estrous cyclicity within 1 week and reduced the elevated hypothalamic GnRH and AR expression levels.
Negative_regulation (reduced) of Positive_regulation (elevated) of GnRH associated with acupuncture
12) Confidence 0.37 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2722078 Disease Relevance 0.57 Pain Relevance 0.32
Our results demonstrate that melatonin replacement delays the increase in LH serum levels and the decrease in LH response to GnRH that occur in 18-month-old control animals.
Negative_regulation (decrease) of Positive_regulation (response) of GnRH
13) Confidence 0.35 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1436374 Disease Relevance 0.15 Pain Relevance 0.14
Hyposmolar stimulation of secretion of thyrotropin, prolactin, and luteinizing hormone does not require extracellular calcium and is not inhibited by colchicine, cytochalasin B, ouabain, or tetrodotoxin.
Negative_regulation (inhibited) of Positive_regulation (stimulation) of luteinizing hormone associated with tetrodotoxin
14) Confidence 0.35 Published 1990 Journal Proc. Soc. Exp. Biol. Med. Section Title Doc Link 2106140 Disease Relevance 0 Pain Relevance 0.25
However, these two events are not coupled as morphine, which amplifies NE-induced LHRH/LH release, also blocks NE-induced increases in LHRH mRNA levels.
Negative_regulation (blocks) of Positive_regulation (increases) of LHRH mRNA associated with morphine
15) Confidence 0.30 Published 1994 Journal Acta. Biol. Hung. Section Abstract Doc Link 7725817 Disease Relevance 0 Pain Relevance 0.38
Nicotine treatment blocked naloxone induced LH release and reduced LHRH induced increases in serum LH.
Negative_regulation (reduced) of Positive_regulation (increases) of LHRH associated with nicotine and narcan
16) Confidence 0.30 Published 1997 Journal Life Sci. Section Abstract Doc Link 9194685 Disease Relevance 0 Pain Relevance 0.65
Baclofen, a specific GABA-B type receptor agonist, had no effect on basal LHRH release, but completely suppressed naloxone-stimulated LHRH and PGE2 secretion.
Negative_regulation (suppressed) of Positive_regulation (naloxone-stimulated) of LHRH in PGE2 associated with gaba, narcan and agonist
17) Confidence 0.20 Published 1989 Journal Endocrinology Section Abstract Doc Link 2544412 Disease Relevance 0 Pain Relevance 0.81
Monoaminergic antagonists which block naloxone-induced release of luteinizing hormone bind selectively to hypothalamic opiate receptors.
Negative_regulation (block) of Positive_regulation (naloxone-induced) of luteinizing hormone associated with antagonist, narcan, opiate and monoamine
18) Confidence 0.10 Published 1983 Journal Brain Res. Section Title Doc Link 6315167 Disease Relevance 0 Pain Relevance 1.00
LH response to LHRH was significantly decreased in RHD patients v. controls denoting delayed maturation of the hypothalamic-pituitary gonadal axis.
Negative_regulation (decreased) of Positive_regulation (response) of LHRH in gonadal associated with rheumatic heart disease
19) Confidence 0.05 Published 1997 Journal J. Trop. Pediatr. Section Abstract Doc Link 9078821 Disease Relevance 0.67 Pain Relevance 0.15

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