INT97859

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 6.66
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Npc1) nuclear envelope (Npc1) Golgi apparatus (Npc1)
endoplasmic reticulum (Npc1) plasma membrane (Npc1) lysosome (Npc1)
Anatomy Link Frequency
vesicles 1
Npc1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 51 96.48 Very High Very High Very High
fibrosis 1 91.04 High High
positron emission tomography 57 72.56 Quite High
cytokine 1 56.44 Quite High
Inflammation 2 55.68 Quite High
Serotonin 9 50.00 Quite Low
anesthesia 2 43.84 Quite Low
drug abuse 12 5.00 Very Low Very Low Very Low
antiepileptic Drug 6 5.00 Very Low Very Low Very Low
peripheral neuropathy 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 666 100.00 Very High Very High Very High
Pick Disease Of The Brain 73 100.00 Very High Very High Very High
Atherosclerosis 24 98.68 Very High Very High Very High
Disorder Of Lipid Metabolism 20 98.04 Very High Very High Very High
Stress 4 95.44 Very High Very High Very High
Lipidosis 37 93.48 High High
Emphysema 1 91.96 High High
Congenital Anomalies 69 91.92 High High
Asthma 1 91.36 High High
Cystic Fibrosis 1 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NPC1 protein is a membrane protein localized in the late endosomes and regulates intracellular cholesterol trafficking [6].
Localization (localized) of NPC1 protein
1) Confidence 0.75 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 0.74 Pain Relevance 0
Contrary to the NPC1 protein, the NPC2 protein is small (132 amino acids), soluble, secreted and recaptured.
Localization (secreted) of NPC1
2) Confidence 0.74 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0 Pain Relevance 0
NPC1 protein possesses a sterol-sensing domain and has been localized to vesicles that are believed to facilitate the recycling of unesterified cholesterol from late endosomes/lysosomes to the ER and Golgi.
Localization (localized) of NPC1 in vesicles
3) Confidence 0.72 Published 2001 Journal Curr. Biol. Section Abstract Doc Link 11525744 Disease Relevance 0.58 Pain Relevance 0
As regards therapy, because the NPC1 protein, unlike many other lysosomal proteins, is not secreted and recaptured, many therapeutic strategies that are currently holding promises for the future seem not easily applicable to NP-C, including cell and gene therapy.
Neg (not) Localization (secreted) of NPC1 associated with disease
4) Confidence 0.70 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.45 Pain Relevance 0
Deletion of NPC1 in BM-derived cells accelerated atherosclerosis by impairing cholesterol efflux and promoting cellular oxidative stress.
Localization (Deletion) of NPC1 associated with stress and atherosclerosis
5) Confidence 0.66 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 1.51 Pain Relevance 0
Definition of Niemann-Pick disease type C
Localization (disease) of Niemann-Pick associated with pick disease of the brain
6) Confidence 0.64 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.38 Pain Relevance 0
From a practical standpoint, no patient should today be longer qualified of suffering from "Niemann-Pick disease" without specification of the subgroup, either acid sphingomyelinase deficiency or type C.


Localization (disease) of Niemann-Pick associated with pick disease of the brain
7) Confidence 0.64 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.71 Pain Relevance 0
Disease name and synonyms

"Niemann-Pick disease type C" (or "Niemann-Pick C disease"), often abbreviated as NP-C (or NPC), is currently the generic name widely used to designate the condition, irrespective of which gene, NPC1 or NPC2, is mutated.

Localization (disease) of Niemann-Pick associated with pick disease of the brain and disease
8) Confidence 0.64 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.76 Pain Relevance 0
Disease name and synonyms

"Niemann-Pick disease type C" (or "Niemann-Pick C disease"), often abbreviated as NP-C (or NPC), is currently the generic name widely used to designate the condition, irrespective of which gene, NPC1 or NPC2, is mutated.

Localization (disease) of Niemann-Pick associated with pick disease of the brain and disease
9) Confidence 0.64 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.87 Pain Relevance 0
Newer versions of SPM have now been released (SPM5 and SPM8), although much of the add-on functionality(ies) are for functional Magnetic Resonance Imaging (fMRI) analysis.
Localization (released) of SPM8 associated with imagery
10) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 0.06 Pain Relevance 0.08
Newer versions of SPM have now been released (SPM5 and SPM8), although much of the add-on functionality(ies) are for functional Magnetic Resonance Imaging (fMRI) analysis.
Localization (released) of SPM5 associated with imagery
11) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 0.06 Pain Relevance 0.08
In this study, another dose of D-SPM/pDNA (at w/w ratio of 16 and pDNA amount of 13.5??
Localization (dose) of D-SPM/pDNA
12) Confidence 0.26 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0.49 Pain Relevance 0.10
Newer versions of SPM have now been released (SPM5 and SPM8), although much of the add-on functionality(ies) are for functional Magnetic Resonance Imaging (fMRI) analysis.
Localization (released) of SPM associated with imagery
13) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 0.06 Pain Relevance 0.08

General Comments

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