INT97863

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Context Info
Confidence 0.05
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (NOS1, GRHPR) cytoplasm (NOS1, GRHPR) cytosol (NOS1)
small molecule metabolic process (GRHPR) cytoskeleton (NOS1) cellular nitrogen compound metabolic process (GRHPR)
NOS1 (Homo sapiens)
GRHPR (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 7 99.30 Very High Very High Very High
antagonist 2 92.96 High High
agonist 1 89.40 High High
MU agonist 4 72.92 Quite High
opioid receptor 1 57.52 Quite High
withdrawal 1 50.96 Quite High
tolerance 1 49.56 Quite Low
Disease Link Frequency Relevance Heat
Breast Cancer 3 75.00 Quite High
Syndrome 1 51.36 Quite High
Opiate Addiction 1 50.96 Quite High
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of this interaction revealed that opioids modify the dimeric active form of NOS, through binding to the reductase part of the molecule, acting as non-competitive inhibitors of the enzyme.
NOS Binding (binding) of reductase associated with opioid
1) Confidence 0.05 Published 2001 Journal Cell Death Differ. Section Abstract Doc Link 11526449 Disease Relevance 0.23 Pain Relevance 0.77

General Comments

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