INT97868

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Context Info
Confidence 0.09
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) signal transduction (Chrna2)
plasma membrane (Chrna2) lipid metabolic process (Acot1) cytoplasm (Acot1)
Anatomy Link Frequency
muscle 2
Chrna2 (Rattus norvegicus)
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 5 98.82 Very High Very High Very High
antidepressant 1 84.64 Quite High
Potency 2 63.08 Quite High
tricyclic antidepressant 1 57.32 Quite High
fluoxetine 2 46.52 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that monoamine-uptake inhibitors reduce ACh-currents and that imipramine regulates reversibly and non- competitively neuronal alpha2beta4 and muscle AChRs through similar mechanisms, perhaps by interacting externally on a non-conducting state of the AChR and by blocking the open receptor-channel complex close to the vestibule of the channel.
AChR Binding (interacting) of in muscle Regulation (regulates) of AChRs associated with monoamine
1) Confidence 0.09 Published 2001 Journal Mol. Psychiatry Section Abstract Doc Link 11526465 Disease Relevance 0 Pain Relevance 0.23

General Comments

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