INT97869

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Context Info
Confidence 0.25
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.79
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
neurons 4
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Locus ceruleus 1 99.68 Very High Very High Very High
Dopamine 136 92.56 High High
withdrawal 4 92.36 High High
opiate 4 91.92 High High
Eae 8 75.00 Quite High
medulla 2 74.88 Quite High
Morphine 1 71.60 Quite High
5HT 1 64.64 Quite High
midbrain 27 58.04 Quite High
Catecholamine 1 56.88 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 108 99.82 Very High Very High Very High
Substance Withdrawal Syndrome 1 88.24 High High
INFLAMMATION 52 50.00 Quite Low
Aging 18 38.08 Quite Low
Disease 40 8.16 Low Low
Toxicity 16 5.00 Very Low Very Low Very Low
Death 11 5.00 Very Low Very Low Very Low
Apoptosis 11 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 10 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HCT1026 inhibits MPTP-induced loss of striatal TH and DAT at mRNA and protein levels
Negative_regulation (loss) of Positive_regulation (striatal) of TH associated with parkinson's disease
1) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.70 Pain Relevance 0.16
Four weeks after the lesion, control 6OHDA-treated mice showed an extensive loss of TH positive SNc neurons in the ipsilateral or lesioned nigral region (Fig. 8A and B).
Negative_regulation (loss) of Positive_regulation (neurons) of TH in neurons
2) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.45
This occurred in conjunction with altered cAMP-mediated excitation and reduced upregulation of tyrosine hydroxylase in A6 (locus coeruleus) without loss of neurons.
Negative_regulation (reduced) of Positive_regulation (upregulation) of tyrosine hydroxylase in neurons associated with locus ceruleus
3) Confidence 0.19 Published 2001 Journal Mol. Psychiatry Section Abstract Doc Link 11526474 Disease Relevance 0.09 Pain Relevance 0.63

General Comments

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