INT97870

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 9.56
Pain Relevance 7.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
muscle 4
brain 4
skin 4
sensory neurons 2
dentate gyrus 2
Ntf3 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 163 100.00 Very High Very High Very High
Spinal cord 18 100.00 Very High Very High Very High
neurotrophin 3 9 100.00 Very High Very High Very High
medulla 4 100.00 Very High Very High Very High
antidepressant 2 99.90 Very High Very High Very High
Inflammation 41 99.46 Very High Very High Very High
dexamethasone 3 99.40 Very High Very High Very High
Morphine 3 99.40 Very High Very High Very High
withdrawal 10 99.12 Very High Very High Very High
bDMF 59 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 27 99.78 Very High Very High Very High
Infection 79 99.64 Very High Very High Very High
Cold Sores 367 99.56 Very High Very High Very High
Injury 26 99.56 Very High Very High Very High
Substance Withdrawal Syndrome 2 99.48 Very High Very High Very High
INFLAMMATION 49 99.46 Very High Very High Very High
Respiratory Syncytial Virus 27 99.44 Very High Very High Very High
Death 31 99.16 Very High Very High Very High
Apoptosis 45 99.08 Very High Very High Very High
Hyperalgesia 42 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acid-induced hyperalgesia was measured in wild-type and transgenic mice that overexpress neurotrophin-3 (NT-3) in muscle (myo/NT-3 mice).
Positive_regulation (overexpress) of Gene_expression (overexpress) of neurotrophin-3 in muscle associated with targeted disruption and hyperalgesia
1) Confidence 0.70 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15496676 Disease Relevance 0.77 Pain Relevance 0.60
Endogenous NT-3 expression, strikingly absent in noradrenergic neurons of postnatal and adult brain, is present in afferent sources of the dorsal medulla and is upregulated after chronic morphine exposure in noradrenergic projection areas of the ventral forebrain.
Positive_regulation (upregulated) of Gene_expression (expression) of NT-3 in forebrain associated with medulla and morphine
2) Confidence 0.70 Published 2001 Journal Mol. Psychiatry Section Abstract Doc Link 11526474 Disease Relevance 0.10 Pain Relevance 0.71
Overexpression of neurotrophin-3 enhances the mechanical response properties of slowly adapting type 1 afferents and myelinated nociceptors.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of neurotrophin-3 in nociceptors associated with nociceptor
3) Confidence 0.68 Published 2007 Journal Eur. J. Neurosci. Section Title Doc Link 17897394 Disease Relevance 0 Pain Relevance 0.13
Constitutive overexpression of neurotrophin-3 (NT3) in murine skin results in an increased number of sensory neurons within the dorsal root ganglia, an increase of myelinated axons in cutaneous nerves, hyperinnervation of the skin, and an increased number of Merkel cells found in flank skin.
Positive_regulation (overexpression) of Gene_expression (overexpression) of neurotrophin-3 in skin
4) Confidence 0.68 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17897394 Disease Relevance 0 Pain Relevance 0.10
RESULTS: Moderate-intensity aerobic exercise reduced cutaneous and deep tissue hyperalgesia induced by acidic saline and stimulated NT-3 synthesis in skeletal muscle.
Positive_regulation (stimulated) of Gene_expression (synthesis) of NT-3 in skeletal muscle
5) Confidence 0.61 Published 2010 Journal Phys Ther Section Body Doc Link 20338916 Disease Relevance 0.06 Pain Relevance 0
These results indicate that cutaneous NT3 overexpression alters the response properties of specific cutaneous sensory neurons, and that these changes may be due to the modulation of putative mechanosensitive ion channels.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NT3 in sensory neurons
6) Confidence 0.59 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17897394 Disease Relevance 0 Pain Relevance 0.25
Acid-induced hyperalgesia was measured in wild-type and transgenic mice that overexpress neurotrophin-3 (NT-3) in muscle (myo/NT-3 mice).
Positive_regulation (overexpress) of Gene_expression (overexpress) of NT-3 in muscle associated with targeted disruption and hyperalgesia
7) Confidence 0.50 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15496676 Disease Relevance 0.77 Pain Relevance 0.61
Transgene-derived NT-3 expressed by noradrenergic neurons of conditional mutants restored opiate withdrawal symptoms.
Positive_regulation (Transgene-derived) of Gene_expression (Transgene-derived) of NT-3 in neurons associated with opiate and withdrawal
8) Confidence 0.50 Published 2001 Journal Mol. Psychiatry Section Abstract Doc Link 11526474 Disease Relevance 0.10 Pain Relevance 0.66
Constitutive overexpression of neurotrophin-3 (NT3) in murine skin results in an increased number of sensory neurons within the dorsal root ganglia, an increase of myelinated axons in cutaneous nerves, hyperinnervation of the skin, and an increased number of Merkel cells found in flank skin.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NT3 in skin
9) Confidence 0.49 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17897394 Disease Relevance 0 Pain Relevance 0.10
Consistent with the behavioral data, paw palpation of acid-injected mice significantly increased Fos expression in the spinal cord of wild-type but not myo/NT-3 or NT-3-injected mice.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of NT-3 in spinal cord associated with spinal cord
10) Confidence 0.44 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15496676 Disease Relevance 1.06 Pain Relevance 1.13
In this case, removal of either neurotrophin would result in the death of this subpopulation.
Positive_regulation (removal) of Gene_expression (removal) of neurotrophin associated with death
11) Confidence 0.42 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.37 Pain Relevance 0.29
Overexpression of NT3 significantly increased the responses of slowly adapting type 1 (SA1) low-threshold mechanoreceptors and Adelta high-threshold mechanoreceptors to suprathreshold mechanical stimulation.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of NT3 in mechanoreceptors associated with adelta
12) Confidence 0.40 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17897394 Disease Relevance 0 Pain Relevance 0.12
The neurotrophic factor neurotrophin 3 (NT3) is expressed at high levels in the dentate gyrus [38].
Positive_regulation (levels) of Gene_expression (expressed) of neurotrophic factor neurotrophin 3 in dentate gyrus associated with neurotrophin 3
13) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0.36 Pain Relevance 0.23
Previous reports have demonstrated that following peripheral inflammation and tissue injury, a variety of inflammatory, immune and stromal cells upregulate the expression of NGF, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) whose cognate receptors are TrkA, TrkB and TrkC respectively.
Positive_regulation (upregulate) of Gene_expression (expression) of neurotrophin-3 in brain associated with nerve growth factor, inflammation and injury
14) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 1.52 Pain Relevance 0.79
Similarly, retinoids, AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor agonists, selective serotonin reuptake inhibitors, serotonin/norepiephrine reuptake inhibitors, and tricylic antidepressants all increase neurotrophin expression [105].
Positive_regulation (increase) of Gene_expression (expression) of neurotrophin associated with antidepressant, agonist, serotonin and ssri
15) Confidence 0.12 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.66 Pain Relevance 0.49
In a further study aimed to determine whether an HSV latency promoter can prolong expression of neurotrophin 3 (NT-3), it has been shown that the continuous production of NT-3 by Lap2-driven long-term expression of the transgene from an HSV vector protects against progression of diabetic neuropathy in mice [31].


Positive_regulation (prolong) of Gene_expression (expression) of neurotrophin 3 associated with cold sores, neurotrophin 3 and diabetic neuropathy
16) Confidence 0.10 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.57 Pain Relevance 0.66
Administration of dexamethasone, a synthetic glucocorticoid, elevates brain levels of NGF, BDNF, and NT-3 following injury [73-76].
Positive_regulation (elevates) of Gene_expression (levels) of NT-3 in brain associated with nerve growth factor, injury and dexamethasone
17) Confidence 0.07 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 1.20 Pain Relevance 0.52
Recent studies show that RSV infection promotes a large increase in the expression of nerve growth factor (NGF) and neurotrophin receptors (Hu et al. 2002).
Positive_regulation (increase) of Gene_expression (expression) of neurotrophin in nerve associated with nerve growth factor, infection and respiratory syncytial virus
18) Confidence 0.04 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.71 Pain Relevance 0.40
Finally, overexpression of NT-3 and BDNF increased the number of MCs [55], [56].
Positive_regulation (overexpression) of Gene_expression (overexpression) of NT-3
19) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0.32 Pain Relevance 0

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