INT97871

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2011
Negated 2
Speculated 1
Reported most in Abstract
Documents 47
Total Number 50
Disease Relevance 25.90
Pain Relevance 15.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
brain 5
neurons 5
muscle 3
dentate gyrus 2
pyramidal neurons 2
Ntf3 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 342 100.00 Very High Very High Very High
neurotrophin 3 51 100.00 Very High Very High Very High
Spinal cord 37 100.00 Very High Very High Very High
sodium channel 17 100.00 Very High Very High Very High
Calcium channel 10 100.00 Very High Very High Very High
bDMF 119 99.90 Very High Very High Very High
analgesia 5 99.90 Very High Very High Very High
antidepressant 4 99.72 Very High Very High Very High
tail-flick 1 99.72 Very High Very High Very High
Pyramidal cell 20 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 71 99.78 Very High Very High Very High
Injury 69 99.56 Very High Very High Very High
Depressive Disorder 4 99.52 Very High Very High Very High
Substance Withdrawal Syndrome 4 99.48 Very High Very High Very High
Infection 381 99.42 Very High Very High Very High
Cold Sores 1101 99.40 Very High Very High Very High
INFLAMMATION 185 99.16 Very High Very High Very High
Death 73 99.16 Very High Very High Very High
Respiratory Syncytial Virus 54 99.12 Very High Very High Very High
Apoptosis 152 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acid-induced hyperalgesia was measured in wild-type and transgenic mice that overexpress neurotrophin-3 (NT-3) in muscle (myo/NT-3 mice).
Gene_expression (overexpress) of neurotrophin-3 in muscle associated with targeted disruption and hyperalgesia
1) Confidence 0.78 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15496676 Disease Relevance 0.77 Pain Relevance 0.60
Acid-induced hyperalgesia was measured in wild-type and transgenic mice that overexpress neurotrophin-3 (NT-3) in muscle (myo/NT-3 mice).
Gene_expression (overexpress) of NT-3 in muscle associated with targeted disruption and hyperalgesia
2) Confidence 0.78 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15496676 Disease Relevance 0.77 Pain Relevance 0.61
Neurotrophin-3 (NT-3), its cognate receptor trkC, and voltage-gated calcium channels are coexpressed by embryonic pyramidal neurons before target contact, but their functions at this stage of development are still unclear.
Gene_expression (coexpressed) of NT-3 in pyramidal neurons associated with pyramidal cell and calcium channel
3) Confidence 0.78 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11698591 Disease Relevance 0 Pain Relevance 0.24
Neurotrophin-3 (NT-3), its cognate receptor trkC, and voltage-gated calcium channels are coexpressed by embryonic pyramidal neurons before target contact, but their functions at this stage of development are still unclear.
Gene_expression (coexpressed) of Neurotrophin-3 in pyramidal neurons associated with pyramidal cell and calcium channel
4) Confidence 0.78 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11698591 Disease Relevance 0 Pain Relevance 0.24
Aerobic exercise alters analgesia and neurotrophin-3 synthesis in an animal model of chronic widespread pain.
Gene_expression (synthesis) of neurotrophin-3 associated with pain, fibrositis and analgesia
5) Confidence 0.78 Published 2010 Journal Phys Ther Section Title Doc Link 20338916 Disease Relevance 0.37 Pain Relevance 0.70
Transgene-derived NT-3 expressed by noradrenergic neurons of conditional mutants restored opiate withdrawal symptoms.
Gene_expression (expressed) of NT-3 in neurons associated with opiate and withdrawal
6) Confidence 0.78 Published 2001 Journal Mol. Psychiatry Section Abstract Doc Link 11526474 Disease Relevance 0.10 Pain Relevance 0.66
Endogenous NT-3 expression, strikingly absent in noradrenergic neurons of postnatal and adult brain, is present in afferent sources of the dorsal medulla and is upregulated after chronic morphine exposure in noradrenergic projection areas of the ventral forebrain.
Gene_expression (expression) of NT-3 in forebrain associated with medulla and morphine
7) Confidence 0.78 Published 2001 Journal Mol. Psychiatry Section Abstract Doc Link 11526474 Disease Relevance 0.10 Pain Relevance 0.69
Overexpression of neurotrophin-3 enhances the mechanical response properties of slowly adapting type 1 afferents and myelinated nociceptors.
Gene_expression (Overexpression) of neurotrophin-3 in nociceptors associated with nociceptor
8) Confidence 0.76 Published 2007 Journal Eur. J. Neurosci. Section Title Doc Link 17897394 Disease Relevance 0 Pain Relevance 0.13
Constitutive overexpression of neurotrophin-3 (NT3) in murine skin results in an increased number of sensory neurons within the dorsal root ganglia, an increase of myelinated axons in cutaneous nerves, hyperinnervation of the skin, and an increased number of Merkel cells found in flank skin.
Gene_expression (overexpression) of neurotrophin-3 in skin
9) Confidence 0.76 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17897394 Disease Relevance 0 Pain Relevance 0.10
Constitutive overexpression of neurotrophin-3 (NT3) in murine skin results in an increased number of sensory neurons within the dorsal root ganglia, an increase of myelinated axons in cutaneous nerves, hyperinnervation of the skin, and an increased number of Merkel cells found in flank skin.
Gene_expression (overexpression) of NT3 in skin
10) Confidence 0.76 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17897394 Disease Relevance 0 Pain Relevance 0.10
BDNF and NT3 are expressed in gustatory papillae, taste buds, geniculate ganglia, and in the rostral nucleus of the solitary tract (NTS) [51,55-61].
Gene_expression (expressed) of NT3 in ganglia associated with bdmf
11) Confidence 0.74 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.29 Pain Relevance 0.12
In addition, the increase in NT-3 protein was significant in the gastrocnemius muscle but not in the soleus muscle, suggesting that exercise can preferentially target NT-3 synthesis in specific muscle types.
Gene_expression (synthesis) of NT-3 in muscle
12) Confidence 0.68 Published 2010 Journal Phys Ther Section Body Doc Link 20338916 Disease Relevance 0.05 Pain Relevance 0
RESULTS: Moderate-intensity aerobic exercise reduced cutaneous and deep tissue hyperalgesia induced by acidic saline and stimulated NT-3 synthesis in skeletal muscle.
Gene_expression (synthesis) of NT-3 in skeletal muscle
13) Confidence 0.68 Published 2010 Journal Phys Ther Section Body Doc Link 20338916 Disease Relevance 0.06 Pain Relevance 0
NT-3 expressed by non-catecholaminergic neurons may modulate opiate withdrawal and noradrenergic signalling.
Gene_expression (expressed) of NT-3 in neurons associated with opiate and withdrawal
14) Confidence 0.68 Published 2001 Journal Mol. Psychiatry Section Abstract Doc Link 11526474 Disease Relevance 0.09 Pain Relevance 0.69
Transgene-derived NT-3 expressed by noradrenergic neurons of conditional mutants restored opiate withdrawal symptoms.
Gene_expression (Transgene-derived) of NT-3 in neurons associated with opiate and withdrawal
15) Confidence 0.67 Published 2001 Journal Mol. Psychiatry Section Abstract Doc Link 11526474 Disease Relevance 0.10 Pain Relevance 0.66
These results indicate that cutaneous NT3 overexpression alters the response properties of specific cutaneous sensory neurons, and that these changes may be due to the modulation of putative mechanosensitive ion channels.
Gene_expression (overexpression) of NT3 in sensory neurons
16) Confidence 0.66 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17897394 Disease Relevance 0 Pain Relevance 0.25
sites and/or factors other than BDNF/TrkB signaling such as NT3/TrkC.
Gene_expression (signaling) of NT3
17) Confidence 0.65 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0
Reduced DCX expression was also associated with decreased neurotrophin expression.
Gene_expression (expression) of neurotrophin
18) Confidence 0.62 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 1.08 Pain Relevance 0
Consistent with the behavioral data, paw palpation of acid-injected mice significantly increased Fos expression in the spinal cord of wild-type but not myo/NT-3 or NT-3-injected mice.
Gene_expression (expression) of NT-3 in spinal cord associated with spinal cord
19) Confidence 0.59 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15496676 Disease Relevance 1.05 Pain Relevance 1.12
In this case, removal of either neurotrophin would result in the death of this subpopulation.
Gene_expression (removal) of neurotrophin associated with death
20) Confidence 0.56 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.37 Pain Relevance 0.29

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